Jia-Sin Ong

Universiti Sains Malaysia

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Min‐Tze Liong

Universiti Sains Malaysia

Yan-Yan Hor

Yeungnam University

Lee-Ching Lew

Jeonnam Bioindustry Foundation

Amy Sie-Yik Lau

Universiti Sains Malaysia

Li Oon Chuah

Universiti Sains Malaysia

Azali Azlan

Universiti Sains Malaysia

Yeong Yeh Lee

Hospital Universiti Sains Malaysia

Sy Bing Choi

UCSI University

Ghows Azzam

Universiti Sains Malaysia

Min‐Tze Liong

Universiti Sains Malaysia

Cooperative Institutions

Universiti Sains Malaysia

Hospital Universiti Sains Malaysia

Universiti Putra Malaysia

Megmilk Snow Brand (Japan)

Morinaga (Japan)

RIKEN Center for Integrative Medical Sciences

Yokohama City University

Ministry of Agriculture and Rural Affairs

Inner Mongolia Agricultural University

Juntendo University

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Probiotic Lactobacillus casei Zhang (LCZ) alleviates respiratory, gastrointestinal & RBC abnormality via immuno-modulatory, anti-inflammatory & anti-oxidative actions

Journal of Functional Foods (2018)

Yan-Yan Hor Lee-Ching Lew Amy Sie-Yik Lau Jia-Sin Ong Li‐Oon Chuah

Lactobacillus casei

Common cold

10.1016/j.jff.2018.03.017

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Citations (65)

Bifidobacterium longum BB536 alleviated upper respiratory illnesses and modulated gut microbiota profiles in Malaysian pre-school children

Beneficial Microbes (2017)

Amy-Sie-Yik Lau Naotake Yanagisawa Yan-Yan Hor Lee-Ching Lew Jia-Sin Ong

This 10-months randomised, double-blind, parallel and placebo-controlled study evaluated the effects of Bifidobacterium longum BB536 on diarrhoea and/or upper respiratory illnesses in 520 healthy Malaysian pre-school children aged 2-6 years old. The subjects randomly received a one-gram sachet containing either BB536 (5×109 cfu) or placebo daily. Data analysis was performed on 219 subjects who fully complied over 10-months (placebo n=110, BB536 n=109). While BB536 did not exert significant effects against diarrhoea in children, Poisson regression with generalised estimating equations model indicated significant intergroup difference in the mean number of times of respiratory illnesses over 10 months. The duration of sore throat was reduced by 46% ( P =0.018), with marginal reduction for duration of fever (reduced by 27%, P =0.084), runny nose (reduced by 15%, P =0.087) and cough (reduced by 16%, P =0.087) as compared to the placebo. Principal coordinate analysis at genus level of the gut microbiota revealed significant differences between 0 and 10 months in the BB536 group ( P <0.01) but not in placebo group ( P >0.05). The abundance of the genus Faecalibacterium which is associated with anti-inflammatory and immuno-modulatory properties was significantly higher in the BB536 group ( P <0.05) compared to the placebo group. Altogether, our present study illustrated the potential protective effects of BB536 against upper respiratory illnesses in pre-school Malaysian children, with gut microbiota modulating properties.

Bifidobacterium longum

10.3920/bm2017.0063

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Citations (49)

Gut Microbiome and Stress

Microbiology monographs (2015)

Winnie-Pui-Pui Liew Jia-Sin Ong Chee‐Yuen Gan Sawibah Yahaya Boon Yin Khoo

Gut–brain axis

Gut microbiome

Human Microbiome Project

10.1007/978-3-319-23213-3_11

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Citations (1)

Effect of Electroporation on Bioconversion of Isoflavones and Probiotic Properties of Parents and Subsequent Passages of Bifidobacterium Longum

Applied Biochemistry and Biotechnology (2014)

Siok Koon Yeo Jia-Sin Ong Min‐Tze Liong

Bifidobacterium longum

Bioconversion

Bifidobacterium breve

10.1007/s12010-014-1141-6

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Citations (5)

Lactobacilli modulated AMPK activity and prevented telomere shortening in ageing rats

Beneficial Microbes (2019)

Lee-Ching Lew Yan-Yan Hor Mohd Hafiidz Jaafar Amy Sie-Yik Lau Jia-Sin Ong

This study aimed to evaluate the anti-ageing effects of different strains of lactobacilli putative probiotics on an ageing rat model as induced by D-galactose and a high fat diet. Male Sprague-Dawley rats were fed with high fat diet (54% kcal fat) and injected with D-galactose daily for 12 weeks to induce ageing. The effects of putative probiotic strains on age-related impairment such as telomere length, plasma lipid peroxidation, hepatic 5'adenosine monophosphate-activated protein kinase (AMPK) expression, as well as endurance performance were evaluated. Administration of statin, Lactobacillus plantarum DR7 (LP-DR7), Lactobacillus fermentum DR9 (LF-DR9), and Lactobacillus reuteri 8513d (LR-8513d) significantly reduced the shortening of telomere and increased the expression of AMPK subunit-α1 (P<0.05). Plasma lipid peroxidation was lower (P<0.05) in groups administered with statin and LF-DR9 as compared to the control. AMPK subunit-α2 was elevated in rats administered with LP-DR7 as compared to the control (P<0.05). Using an in vivo ageing rat model, the current study has illustrated the potentials of lactobacilli putative probiotics in alleviation of age-related impairment in a strain-dependent manner.

Lactobacillus reuteri

10.3920/bm2019.0058

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Citations (29)

Probiotics: The Next Dietary Strategy against Brain Aging

Preventive Nutrition and Food Science (2022)

Jia-Sin Ong Lee-Ching Lew Yan-Yan Hor Min‐Tze Liong

Owing to their long history of safe use, probiotic microorganisms, typically from the genus Lactobacillus, have long been recognized, especially in traditional and fermented food industries.Although conventionally used for dairy, meat, and vegetable fermentation, the use of probiotics in health foods, supplements, and nutraceuticals has gradually increased.Over the past two decades, the importance of probiotics in improving gut health and immunity as well as alleviating metabolic diseases has been recognized.The new concept of a gut-heart-brain axis has led to the development of various innovations and strategies related to the introduction of probiotics in food and diet.Probiotics influence gut microbiota profiles, inflammation, and disorders and directly impact brain neurotransmitter pathways.As brain health often declines with age, the concept of probiotics being beneficial for the aging brain has also gained much momentum and emphasis in both research and product development.In this review, the concept of the aging brain, different in vivo aging models, and various aging-related benefits of probiotics are discussed.

Nutraceutical

Health Benefits

Gut–brain axis

Healthy aging

Brain Aging

Functional food

10.3746/pnf.2022.27.1.1

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Citations (8)

Lactobacillus sp. improved microbiota and metabolite profiles of aging rats

Pharmacological Research (2019)

Yan-Yan Hor Lee-Ching Lew Mohamad Hafis Jaafar Amy Sie-Yik Lau Jia-Sin Ong