Xiaoyan Feng

Chengdu Third People's Hospital

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Gang An

Institute of Hematology & Blood Diseases Hospital

Zhaoming Li

First Affiliated Hospital of Zhengzhou University

Yan Xu

Institute of Hematology & Blood Diseases Hospital

Lugui Qiu

Chinese Academy of Medical Sciences & Peking Union Medical College

Shuhui Deng

Institute of Hematology & Blood Diseases Hospital

Xiaoqi Qin

Beijing University of Posts and Telecommunications

Shuhua Yi

Institute of Hematology & Blood Diseases Hospital

Chirag Acharya

Dana-Farber Cancer Institute

Mingzhi Zhang

First Affiliated Hospital of Zhengzhou University

Yu‐Tzu Tai

Harvard University

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First Affiliated Hospital of Zhengzhou University

125

Chinese Academy of Sciences

108

Chinese Academy of Medical Sciences & Peking Union Medical College

Zhengzhou University

Sun Yat-sen University

Shanghai Jiao Tong University

University of Chinese Academy of Sciences

Peking University

Zhejiang University

Institute of Hematology & Blood Diseases Hospital

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Genomic and outcome analysis of adult T-cell lymphoblastic lymphoma

Haematologica (2019)

Zhaoming Li Yue Song Yanjie Zhang Chaoping Li Yingjun Wang

Lymphoblastic lymphoma

10.3324/haematol.2019.220863

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Citations (10)

TREATMENT OF S ZORB REGENERATOR FLUE GAS WITH ORGANIC CATALYST

Shiyou Lian Zhi Yuhuagong (2016)

Xiaoyan Feng W. Tao Zhijie Wang

Source

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Citations (0)

AEG-1 is involved in hypoxia-induced autophagy and decreases chemosensitivity in T-cell lymphoma

Molecular Medicine (2018)

Jiaqin Yan Junhui Zhang Xudong Zhang Xin Li Ling Li

This study was to examine the link between astrocyte elevated gene-1 (AEG-1) and hypoxia induced-chemoresistance in T-cell non-Hodgkin's lymphoma (T-NHL), as well as the underlying molecular mechanisms.Expression of AEG-1, LC3-II, and Beclin-1 were initially examined in human T-NHL tissues (n = 30) and normal lymph node tissues (n = 16) using western blot, real-time PCR and immunohistochemistry. Western blot was also performed to analyze the expression of AEG-1, LC3-II, and Beclin-1 in T-NHL cells (Hut-78 and Jurkat cells) under normoxia and hypoxia. Additionally, the proliferation and apoptosis of Hut-78 cells exposed to different concentration of Adriamycin (ADM) in normoxia and hypoxia were evaluated by MTT and Annexin-V FITC/PI staining assay. Finally, the effects of AEG-1 on Hut-78 cells exposed to ADM in hypoxia were assessed by MTT and Annexin-V FITC/PI staining assay, and 3-MA (autophagy inhibitor) was further used to determine the underlying mechanism.AEG-1, LC3-II and Beclin-1 expression were significantly increased in T-NHL tissues compared with normal tissues. Incubation of Hut-78 and Jurkat cells in hypoxia obviously increased AEG-1, LC3-II and Beclin-1 expression. Hypoxia induced proliferation and reduced apoptosis of Hut-78 cells exposed to ADM. AEG-1 overexpression further increased proliferation and decreased apoptosis of Hut-78 cells exposed to ADM in hypoxia. Moreover, overexpression of AEG-1 significantly inversed 3-MA induced-changes in cell proliferation and apoptosis of Hut-78 cells exposed to ADM in hypoxia.This study suggested that AEG-1 is associated with hypoxia-induced T-NHL chemoresistance via regulating autophagy, uncovering a novel target against hypoxia-induced T-NHL chemoresistance.

MTT assay

Jurkat cells

Hypoxia

10.1186/s10020-018-0033-6

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Citations (21)

Sternal wound infection caused by Mycoplasma hominis in an adult patient: a case report and literature review

BMC Infectious Diseases (2025)

Shuang Li Lili Yang Yuanbiao Guo Xiaoyan Feng Ling Ye

Mycoplasma hominis

10.1186/s12879-025-10607-0

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Non-invasive Urine Test for Molecular Classification of Clinical Significance in Newly Diagnosed Prostate Cancer Patients

Frontiers in Medicine (2021)

Jinan Guo Xuhui Zhang Taolin Xia Heather Johnson Xiaoyan Feng

Objective: To avoid over-treatment of low-risk prostate cancer patients, it is important to identify clinically significant and insignificant cancer for treatment decision-making. However, no accurate test is currently available. Methods: To address this unmet medical need, we developed a novel gene classifier to distinguish clinically significant and insignificant cancer, which were classified based on the National Comprehensive Cancer Network risk stratification guidelines. A non-invasive urine test was developed using quantitative mRNA expression data of 24 genes in the classifier with an algorithm to stratify the clinical significance of the cancer. Two independent, multicenter, retrospective and prospective studies were conducted to assess the diagnostic performance of the 24-Gene Classifier and the current clinicopathological measures by univariate and multivariate logistic regression and discriminant analysis. In addition, assessments were performed in various Gleason grades/ISUP Grade Groups. Results: The results showed high diagnostic accuracy of the 24-Gene Classifier with an AUC of 0.917 (95% CI 0.892–0.942) in the retrospective cohort ( n = 520), AUC of 0.959 (95% CI 0.935–0.983) in the prospective cohort ( n = 207), and AUC of 0.930 (95% 0.912-CI 0.947) in the combination cohort ( n = 727). Univariate and multivariate analysis showed that the 24-Gene Classifier was more accurate than cancer stage, Gleason score, and PSA, especially in the low/intermediate-grade/ISUP Grade Group 1–3 cancer subgroups. Conclusions: The 24-Gene Classifier urine test is an accurate and non-invasive liquid biopsy method for identifying clinically significant prostate cancer in newly diagnosed cancer patients. It has the potential to improve prostate cancer treatment decisions and active surveillance.

10.3389/fmed.2021.721554

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Prognostic impact of hepatitis B virus infection in patients with primary cervical cancer

Cancer Medicine (2021)

Xiaoyan Feng Huaiwu Lu Wei Yuan Meimei Guan Junyi Wang

Hepatitis B virus (HBV) infection has been associated with an increased risk of a few malignancies. However, the prognostic impact of HBV infection remains unclear in cervical cancer.To explore the association between HBV infection and survival outcomes of patients with primary cervical cancer, using overall survival (OS) and disease-free survival (DFS) as primary endpoints.This analysis was performed retrospectively with newly diagnosed cervical cancer patients admitted to the Department of Gynecologic Oncology at the Sun Yat-sen Memorial Hospital of Sun Yat-sen University from June 2013 to October 2019, who were enrolled and followed up. The Kaplan-Meier method and Cox proportional hazard analysis were used to examine the performance of HBV infection in predicting OS and DFS.Patients were followed up for a median of 37.17 months (95% CI, 34.69-39.65). Among the 695 patients, 87 (12.5%) were serologically positive for hepatitis B surface antigen (HBsAg), and 276 (39.7%) had a prior history of HBV infection. There was no significant difference between HBsAg-positive group and HBsAg-negative patients concerning OS or DFS. Multivariate analysis showed prior HBV infection was an independent favorable prognosticator for OS (HR, 0.335; 95% CI, 0.153-0.0.734; p = 0.006) and DFS (HR, 0.398; 95% CI, 0.208-0.691; p = 0.002).We provide the first clinical evidence that suggests prior HBV infection as an independent favorable prognostic factor for patients with primary cervical cancer.

Hepatitis B

10.1002/cam4.4358

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A Phase I Clinical Trial of Chimeric Antigen Receptor-Modified T Cells in Patients with Relapsed and Refractory Lymphoma

Immunotherapy (2020)

Xinfeng Chen Xin Li Yanfen Liu Zhen Zhang Xudong Zhang

Aim: CD19 chimeric antigen receptor (CAR) T cells have been approved by the US FDA for treatment of relapsed and refractory (R/R) B-cell malignancies. Patients & methods: This study investigated the safety and efficacy of autologous 4-1BB costimulatory domain-engineered CD19 CAR-T cells in R/R B-cell lymphoma. Results: After CD19 CAR-T-cell infusion, severe cytokine release syndrome occurred in 28.6% (4/14) of the patients. The overall response rate was 77% with complete remission observed in 6/14 patients at 3 months. A higher tumor burden and grade 3-4 of myelosuppression after chemotherapy were associated with severe cytokine-release syndrome. Notably, combining CD19 CAR-T cells and PD-1 blockade, but not CD19 CAR-T cells alone, reduced intracranial tumor burden in a patient with central invasion of lymphoma. Conclusion: CD19 CAR-T cells could effectively induce tumor remission and PD-1 blockade might improve the efficacy in Chinese patients with R/R B-cell lymphoma.

Cytokine Release Syndrome

Refractory (planetary science)

10.2217/imt-2020-0022

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Citations (17)

The experience of diagnosis and treatment for TAFRO syndrome

Annals of Hematology (2023)

Xiaolong Wu Xudong Zhang Siyu Qian Cunzhen Shi Xin Li

Anasarca

Hematology

Castleman disease

Mitotane

10.1007/s00277-023-05435-8

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Citations (4)

Effect of regeneration solvent on the characteristics of regenerated cellulose from lithium bromide trihydrate molten salt

Cellulose (2020)

Zhonglei Huang Chao Liu Xiaoyan Feng Meiyan Wu Yanjun Tang

Regenerated cellulose

Thermogravimetric analysis

Lithium chloride

Lithium bromide

10.1007/s10570-020-03440-y

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Citations (70)

Ammonia-ethanol-water pretreatment of wheat straw for facilitating enzymatic saccharification integrated with the preparation of submicron lignin spheres

BioResources (2020)

Xihui Zhang Guang Yu Xiaoyan Feng Zhenqiu Li Bin Li

Ammonia-ethanol-water (AEW) pretreatment was adopted to treat wheat straw for ameliorating saccharification with the integrated preparation of submicron lignin spheres (SLS). Results showed that AEW pretreatment could remove 77% of lignin and 90% of extractives, thus increasing specific surface area and porosity of the substrate and finally enhancing the release of fermentable sugars in saccharification. Under the optimal pretreatment conditions (170 °C for 2 h, ethanol concentration 55% (v/v), ammonia concentration 7.5 wt%), the final total sugar yield reached 81.7% after pretreatment and saccharification, which was 2.25 times higher compared to the conventional ethanol organosolv pretreatment. Moreover, washing could be excluded for AEW-pretreated wheat straw before saccharification, and both ethanol and ammonia could be readily recovered and reused, making the AEW pretreatment clean and sustainable. In addition, SLS with hollow structure and average diameter of 161.2 ± 53.6 nm were fabricated using the fractionated lignin, which could offset the overall cost of AEW pretreatment.

Organosolv

Enzymatic Hydrolysis

10.15376/biores.15.3.5087-5109

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Citations (1)