Anjali Pahuja

Objectives To analyse the survival of patients with malignant esophagorespiratory fistulas (ERF) and perform a comparative effectiveness analysis of ERF-directed interventions. Methods Fifty-five patients met our inclusion criteria, and data on ERF-directed interventions (stent placement, surgical repair and best supportive care) and their outcomes, along with clinical and treatment details, were recorded. The primary endpoints were overall survival (OS) and survival after developing ERF (F-OS). Results The median OS and F-OS for the entire cohort was 299 days (SE=23.2) and 123 days (SE=11.63), respectively. On univariable analysis, the American Joint Committee on Cancer (AJCC) stage (I–III vs IV) influenced both OS (403 vs 171 days; p=0.006) and F-OS (129 vs 67 days; p=0.034). Proximal location of ERF influenced OS favourably (494 vs 285 days; p=0.021), whereas patients developing ERF late in their disease course experienced inferior F-OS (96 vs 232 days; p=0.03). On multivariable analysis, the AJCC stage (IV vs I–III, HR=3.03 (1.41–6.50)), time to developing ERF from diagnosis (greater than vs within 3 months, HR=5.82 (1.84–18.36)) and location of ERF (distal vs proximal, HR=2.47 (1.14–5.34)) had a significant impact on F-OS. The comparative efficacy (OS and F-OS) of best supportive care was statistically equivalent to any intervention irrespective of AJCC stage and success/failure of initial or subsequent intervention(s). Conclusions The survival of patients with ERF is dismal, and our analysis suggests that best supportive care results in equivalent OS and F-OS when compared with any intervention.

Subgroup analysis

10.1136/bmjspcare-2020-002370

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Intuitive evaluation of contemporary management strategies in thymoma — the largest Indian experience

Reports of Practical Oncology & Radiotherapy (2023)

Rahul Lal Chowdhary Kundan Singh Chufal Mohamed Ismail Irfan Ahmad M. Jwala

Medical record

10.5603/rpor.a2023.0050

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Metastatic low-grade myoepithelial carcinoma of lung managed with low-dose external beam radiotherapy

Indian Journal of Pathology and Microbiology (2021)

Sunil Pasricha Divya Bansal Ullas Batra Garima Durga Meenakshi Kamboj

Myoepithelial tumor of lung is a rare tumor; the histopathological findings resemble the myoepithelial tumors of the salivary gland. Distinguishing low-grade nonmetastatic myoepithelial carcinoma from benign myoepithelioma can be challenging both radiologically and histomorphologically. We present a case report of a low-grade myoepithelial carcinoma of lung with contralateral lung metastasis which was treated with low-dose external beam radiotherapy

External beam radiotherapy

External beam radiation

10.4103/ijpm.ijpm_385_20

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Paediatric live related renal transplantations: the Jaslok Hospital experience

Transplantation Proceedings (2002)

Sameeran Joshi M.H. Kamat F.P Soonawalla S Bulchand Bhupendra Gandhi

10.1016/s0041-1345(02)03151-2

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