Jie‐Jen Lee

Mackay Memorial Hospital

Author Statistics

Papers

Citation

H-Index

i-10 index

Research Trends

Author Order

Document Type

Co-Authors

Shih‐Ping Cheng

Mackay Memorial Hospital

Tsang‐Pai Liu

Mackay Junior College of Medicine, Nursing and Management

Chien‐Liang Liu

Mackay Medical College

Chien‐Liang Liu

Taipei City Hospital

Chien‐Liang Liu

National Yang Ming Chiao Tung University

Po‐Sheng Yang

Mackay Memorial Hospital

Yuan‐Ching Chang

Mackay Memorial Hospital

Ming‐Nan Chien

Mackay Memorial Hospital

Han‐Hsiang Chen

Chang Gung University

Ming‐Jen Chen

Mackay Medical College

Cooperative Institutions

Mackay Memorial Hospital

Mackay Medical College

Mackay Junior College of Medicine, Nursing and Management

Taipei Medical University

National Yang Ming Chiao Tung University

National Taiwan University

National Taipei University of Technology

Chang Gung University

Taipei Medical University Hospital

Taipei Institute of Pathology

Author Statistics

Papers

Citation

H-Index

i-10 index

Research Field

SURGICAL OUTCOME OF SUPERFICIAL AND DEEP CASTLEMAN DISEASE

ANZ Journal of Surgery (2007)

Chih‐Hao Chen Hung‐Chang Liu Kwang‐Yi Tung Jie‐Jen Lee Chien‐Liang Liu

Castleman disease is a rare lymphoproliferative disease of low malignant potential occurring in two forms, unicentric and multicentric. Surgery, chemotherapy, immunotherapy and radiation therapy have all been used to manage the disease. In this study, we evaluate whether the site of the lesions, that is, superficial or deep, influences the surgical outcome.We retrospectively reviewed the records of 20 patients operated on for Castleman disease from 1994 to 2003, of whom 11 patients had superficial disease and 9 had deep lesions. The end-points of this study were survival and recurrence.Of the 20 patients, 19 had unicentric (cervical in 8, mediastinal in 5, retroperitoneal in 2, axillary in 2, hepatic in 1, and mesenteric in 1) and 1 had multicentric Castleman disease. Among 19 patients who had complete resection (18 with unicentric and 1 with multicentric disease), there has been no evidence of recurrence.Whether Castleman disease is superficial or deep has no effect on surgical outcome as long as resection is complete.

Castleman disease

10.1111/j.1445-2197.2007.04055.x

Cite

Citations (29)

Interaction of Age at Diagnosis with Transcriptional Profiling in Papillary Thyroid Cancer

World Journal of Surgery (2016)

Yi‐Chiung Hsu Chien‐Liang Liu Po‐Sheng Yang Chung‐Hsin Tsai Jie‐Jen Lee

10.1007/s00268-016-3625-8

Cite

Citations (18)

Prolonged Hospital Stay After Parathyroidectomy for Secondary Hyperparathyroidism

World Journal of Surgery (2008)

Shih‐Ping Cheng Chien‐Liang Liu Han‐Hsiang Chen Jie‐Jen Lee Tsang‐Pai Liu

Elevated alkaline phosphatase

Cardiothoracic surgery

10.1007/s00268-008-9787-2

Cite

Citations (38)

Osteocalcin is an Independent Predictor for Hungry Bone Syndrome After Parathyroidectomy

World Journal of Surgery (2019)

Wen‐Ching Ko Chien‐Liang Liu Jie‐Jen Lee Tsang‐Pai Liu Chih‐Jen Wu

10.1007/s00268-019-05251-0

Cite

Citations (12)

Is papillary thyroid microcarcinoma a biologically different disease? A propensity score‐matched analysis

Journal of Surgical Oncology (2019)

Yi‐Chiung Hsu Jie‐Jen Lee Ming‐Nan Chien Ming‐Jen Chen Ching‐Hsiang Leung

Papillary thyroid microcarcinoma exhibits an indolent clinical course and could be a candidate for active surveillance in the appropriate setting. It remains unknown whether papillary microcarcinoma is biologically different from larger papillary carcinoma >1 cm.We analyzed clinicopathological information and transcriptome data of papillary thyroid cancer samples from The Cancer Genome Atlas. Propensity-score matching was used to construct a matched cohort consisting of 29 microcarcinomas and 58 carcinomas. Principal component analysis and unsupervised hierarchical cluster analysis were carried out to investigate the similarity of gene expression profiles.After adjustment for differences in baseline clinicopathological and genetic factors, transcriptome could be grouped mainly on the basis of tumor class (BRAF-like vs RAS-like) and tumor size (microcarcinoma vs carcinoma). The gene set enrichment analysis showed that extracellular matrix-associated pathways were enriched in the MSigDB database.Papillary thyroid microcarcinomas display a distinct gene expression pattern different from the corresponding carcinomas. We hypothesize that tumor microenvironment may play a role in the microcarcinoma/carcinoma phenotypic divergence.

10.1002/jso.25670

Cite

Citations (13)

Tissue‐engineered intervertebral disc and chondrogenesis using human nucleus pulposus regulated through TGF‐β1 in platelet‐rich plasma

Journal of Cellular Physiology (2006)

Weihong Chen Wen‐Cheng Lo Jie‐Jen Lee Ching‐Hua Su Che‐Tong Lin

Abstract Human intervertebral disc (IVD) degeneration often initiated from the human nucleus pulposus (hNP) with aging leading to IVD destruction and extracellular matrix (ECM) depletion. Previously, we have successfully employed transforming growth factor‐β1 (TGF‐β1) to promote chondrogenesis of mesenchymal progenitor cells (MPCs) and immortalized human mesenchymal stem cells. In this study, we examine the role of TGF‐β1 in platelet‐rich plasma (PRP) on disc regeneration, including proliferation, redifferentiation, and the reconstitution of tissue‐engineered NP. hNP cells were isolated from volunteers with different ages and cultured in the presence of PRP. We found that the most effective concentration for hNP proliferation was 1 ng/ml TGF‐β1 in PRP, which was further applied in the following experiments. hNP cell proliferation in all age groups were increased time‐dependently by PRP and cell morphologies showed aggregation. The mRNA of Sox9 , type II collagen , and aggrecan were all significantly upregulated by PRP through RT‐PCR. Glycosaminoglycan (GAG) accumulation reached the highest value at day 7 and continued to day 9 culture. PRP promoted NP regeneration via the Smad pathway was also determined and highly activated p‐Smad2/3 at 30 min and continuously sustained to 120 min. Immunostaining of type II collagen indicates that PRP participates in chondrogenesis of tissue‐engineered NP with collagen scaffolds. We concluded that growth factors in PRP can effectively react as a growth factor cocktail to induce hNP proliferation and differentiation, and also promote tissue‐engineered NP formation. These findings are the first to demonstrate that PRP might be a therapeutic candidate for prevention of disc degeneration. J. Cell. Physiol. 209: 744–754, 2006. © 2006 Wiley‐Liss, Inc.

Aggrecan

Chondrogenesis

Type II collagen

10.1002/jcp.20765

Cite

Citations (138)

Effects of Preoperative Iodine Administration on Thyroidectomy for Hyperthyroidism: A Systematic Review and Meta‐analysis

Otolaryngology (2019)

Chung‐Hsin Tsai Po‐Sheng Yang Jie‐Jen Lee Tsang‐Pai Liu Chi‐Yu Kuo

The current guidelines recommend that potassium iodide be given in the immediate preoperative period for patients with Graves' disease who are undergoing thyroidectomy. Nonetheless, the evidence behind this recommendation is tenuous. The purpose of this study is to clarify the benefits of preoperative iodine administration from published comparative studies.We searched PubMed, Embase, Cochrane, and CINAHL from 1980 to June 2018.Studies were included that compared preoperative iodine administration and no premedication before thyroidectomy. For the meta-analysis, studies were pooled with the random-effects model.A total of 510 patients were divided into the iodine (n = 223) and control (n = 287) groups from 9 selected studies. Preoperative iodine administration was significantly associated with decreased thyroid vascularity and intraoperative blood loss. Significant heterogeneity was present among studies. We found no significant difference in thyroid volume or operative time. Furthermore, the meta-analysis showed no difference in the risk of postoperative complications, including vocal cord palsy, hypoparathyroidism/hypocalcemia, and hemorrhage or hematoma after thyroidectomy.Preoperative iodine administration decreases thyroid vascularity and intraoperative blood loss. Nonetheless, it does not translate to more clinically meaningful differences in terms of operative time and postoperative complications.

Premedication

Vascularity

Postoperative hematoma

10.1177/0194599819829052

Cite

Citations (18)

Transcriptome analysis of papillary thyroid cancer harboring telomerase reverse transcriptase promoter mutation

Head & Neck (2018)

Ming‐Nan Chien Po‐Sheng Yang Yi‐Chiung Hsu Tsang‐Pai Liu Jie‐Jen Lee

Abstract Background Telomerase reverse transcriptase (TERT) promoter mutations have recently been identified as an important prognostic factor in thyroid cancer. Studies suggest that TERT may have noncanonical functions beyond telomere maintenance. Methods Clinicopathological information and transcriptome data for papillary thyroid carcinoma (PTC) samples were obtained from The Cancer Genome Atlas (TCGA). Propensity score matching was performed to adjust for potential confounding variables between the TERT promoter wild‐type group and the mutant group. Gene expression data of 36 patients in the mutant group were systemically compared to those of 72 patients in the wild‐type group. Results Tumors with TERT promoter mutations had a higher TERT expression. Pathways central to DNA damage responses and cell cycle regulation were significantly enriched among 888 upregulated genes. Transporter and metabolic activities were overrepresented among 799 downregulated genes. There was no difference in the expression of most of the thyroid differentiation genes. Conclusion The TERT promoter mutations were associated with proliferative and metabolic alterations in PTC.

10.1002/hed.25385

Cite

Citations (19)

Expression of haem oxygenase‐1 correlates with tumour aggressiveness and BRAF^V^600E expression in thyroid cancer

Histopathology (2014)

Tao‐Yeuan Wang Chien‐Liang Liu Ming‐Jen Chen Jie‐Jen Lee Pou Chu Pun

Haem oxygenase-1 (HO-1) is an inducible enzyme that participates in haem degradation. Recent studies have indicated that HO-1 activation may play a role in tumour development and progression. The aim of this study was to evaluate the expression of HO-1 in thyroid cancer and its clinicopathological significance.We observed up-regulation of HO-1 in papillary thyroid tumours in comparison with normal thyroid tissue. Immunohistochemical analysis revealed that 48% of papillary cancers and 36% of follicular cancers, but none of normal thyroid tissues, were positive for HO-1 expression. Among 129 differentiated thyroid cancers, HO-1 expression was associated with patient age (P = 0.001), TNM stage (P = 0.001), and Mayo Clinic metastasis, patient age, completeness of resection, local invasion and tumour size score (P = 0.001). BRAF V600E expression was evaluated immunohistochemically and validated by Sanger sequencing. There was a strong association between HO-1 and BRAF V600E expression in papillary cancers (P = 0.002).Overexpression of HO-1 in a subset of thyroid cancers is associated with tumour aggressiveness and BRAF V600E expression. HO-1 might have a potential role in prognosis and targeted treatment in patients with thyroid cancer.

Tissue microarray

Sanger sequencing

10.1111/his.12562

Cite

Citations (46)

Aluminum Overload Hampers Symptom Improvement Following Parathyroidectomy for Secondary Hyperparathyroidism

World Journal of Surgery (2014)

Shih‐Ping Cheng Jie‐Jen Lee Tsang‐Pai Liu Han‐Hsiang Chen Chih‐Jen Wu

Cardiothoracic surgery

Bone pain

Vascular surgery

10.1007/s00268-014-2695-8

Cite

Citations (8)