Abbas Pirpour Tazekand

Tabriz University of Medical Sciences

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Parina Asgharian

Tabriz University of Medical Sciences

Daniela Călina

University of Medicine and Pharmacy of Craiova

Reza Rahbarghazi‬

Tabriz University of Medical Sciences

Tohid Ghasemnejad

Tabriz University of Medical Sciences

ЛС

Л С Кожамжарова

Taraz State Pedagogical University

Javad Sharifi‐Rad

Universidad de Especialidades Espíritu Santo

Sanya Haiaty

Tabriz University of Medical Sciences

Muzaffar Hasan

Central Institute of Agricultural Engineering

Mohammad Nouri

Tabriz University of Medical Sciences

Kamran Hosseini

Shiraz University of Medical Sciences

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Tabriz University of Medical Sciences

Biotechnology Research Center

University of Tabriz

Tehran University of Medical Sciences

Delhi Technological University

Imam Reza Hospital

Institute for Health Metrics and Evaluation

University of Washington

Shahid Beheshti University of Medical Sciences

Indian Council of Agricultural Research

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Potential mechanisms of quercetin in cancer prevention: focus on cellular and molecular targets

Cancer Cell International (2022)

Parina Asgharian Abbas Pirpour Tazekand Kamran Hosseini Haleh Forouhandeh Tohid Ghasemnejad

Over the past few years, the cancer-related disease has had a high mortality rate and incidence worldwide, despite clinical advances in cancer treatment. The drugs used for cancer therapy, have high side effects in addition to the high cost. Subsequently, to reduce these side effects, many studies have suggested the use of natural bioactive compounds. Among these, which have recently attracted the attention of many researchers, quercetin has such properties. Quercetin, a plant flavonoid found in fresh fruits, vegetables and citrus fruits, has anti-cancer properties by inhibiting tumor proliferation, invasion, and tumor metastasis. Several studies have demonstrated the anti-cancer mechanism of quercetin, and these mechanisms are controlled through several signalling pathways within the cancer cell. Pathways involved in this process include apoptotic, p53, NF-κB, MAPK, JAK/STAT, PI3K/AKT, and Wnt/β-catenin pathways. In addition to regulating these pathways, quercetin controls the activity of oncogenic and tumor suppressor ncRNAs. Therefore, in this comprehensive review, we summarized the regulation of these signalling pathways by quercetin. The modulatory role of quercetin in the expression of various miRNAs has also been discussed. Understanding the basic anti-cancer mechanisms of these herbal compounds can help prevent and manage many types of cancer.

Signalling pathways

10.1186/s12935-022-02677-w

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In vitro exosomal transfer of Nrf2 led to the oxaliplatin resistance in human colorectal cancer LS174T cells

Cell Biochemistry and Function (2022)

Mostafa Mostafazadeh Houman Kahroba Sanya Haiaty Abbas Pirpour Tazekand Nasser Samadi

Chemotherapy resistance is a serious pitfall in the treatment of colon cancers (CCs). Previous studies have found that exosomes (Exo) play a pivotal role in tumor drug resistance via the transfer of proteins and genetic materials to the acceptor cells. To date, the mechanisms orchestrating Exo-derived resistance in cancer cells have been the center of attention. Herein, we aimed to evaluate the role of exosomal nuclear factor erythroid 2-related factor 2 (Nrf2) on oxaliplatin (1-OHP) resistance in human colorectal cancer LS174T cells in vitro. To this end, exosomal-Nrf2-mediated 1-OHP resistance was examined using different assays. Exo was isolated from resistant LS174T cells (LS174T/R) and added to the culture medium of sensitive LS174T cells (LS174T/S). According to our data, LS174T/S cells successfully adsorbed PKH26-Exo driven from LS174T/R cells. Western blotting showed an increased Nrf2 level in Exo isolated from LS174T/R cells compared to LS174T/S cell-derived Exo (p < .05). The incubation of LS174T/S cells with LS174T/R-derived Exo increased half-maximal inhibitory concentration values in response to treatment with 1-OHP (p < .05). Besides this, the apoptotic changes were diminished in LS174T/S cells after incubation with LS174T/R-derived Exo. Of note, the exposure of LS174T/S cells to LS174T/R cell-derived Exo increased the expression of Nrf2 and P-glycoprotein (P-gp) compared to the nontreated LS174T/S cells (p < .05). In line with these changes, lower intracellular Rhodamin 123 content was detected in Exo-treated cells compared to the nontreated LS174T/S cells. Exo increased migration and clonogenic capacity of LS174T/S cells after incubation with Exo-derived from resistant cells. Of note, inhibition of Nrf2 with a specific blocker, brusatol, blunted these effects. Taken together, Exo-mediated transfer of Nrf2 is involved in the development of oxaliplatin resistance in CC cells by upregulating P-gp.

10.1002/cbf.3703

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