Hongmei Wang

Nanchang University

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Xiao‐Hua Zeng

Chongqing Cancer Hospital

Yun‐Yin Niu

Zhengzhou University

Hong‐Wei Hou

Institute of Hydrobiology

Wei‐Ping Min

Western University

Xiaoping Zeng

Guiyang Medical University

Lisha Song

Shandong University of Technology

Ben‐Lai Wu

Zhengzhou University

Xiao-Rui Lv

Zhengzhou University

Yong-Zhen Qiao

Nanjing Forestry University

Lingfang Wang

Nanchang University

Cooperative Institutions

Nanchang University

Chinese Academy of Sciences

Nanjing Medical University

Chinese Academy of Medical Sciences & Peking Union Medical College

Sun Yat-sen University

Shanghai Jiao Tong University

Peking University

Central South University

Huazhong University of Science and Technology

First Affiliated Hospital of Nanchang University

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Soluble Receptor for Advanced Glycation Endproducts (sRAGE) Induces Human Monocyte Survival and Differentiation (38.23)

The Journal of Immunology (2009)

Yijie Wang Hongmei Wang Melissa G. Piper-Hunter Sara McMaken Xiaokui Mo

Abstract The receptor for advanced glycation end-products (RAGE) is a transmembrane receptor of the immunoglobulin super family or is the soluble portion of extracellular domain of RAGE (sRAGE). sRAGE is a competitive, negative regulator of transmembrane RAGE. RAGE and its ligands are overexpressed in a wide variety of diseases. However, the biological function of RAGE and sRAGE on human mononuclear phagocytes is unclear. Using flow cytometry, we found that sRAGE directly bound to human monocytes to mediate their survival and differentiation into macrophages, events that were dependent on cellular adhesion. In both monocytes and MDM, sRAGE treatment activated Akt, Erk and NFk-B signaling, and decreased caspase-3 activity. Interestingly, while sRAGE bound the surface of suspended pre-monocytic leukemic THP1 cells, it failed to stimulate intracellular signaling or cellular differentiation. Furthermore, we found sRAGE induced monocytes chemotaxis in vitro and recruited monocytes to the lung in vivo. Our data suggest a novel role for sRAGE in mononuclear phagocyte survival, differentiation, and cell recruitment of human monocytes. These observations suggest a potential role for sRAGE to modulate organ-based inflammation.

RAGE

Monocyte

10.4049/jimmunol.182.supp.38.23

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Table S1. miRNA that are differentially expressed in CD8+PD-1+ vs. CD8+PD-1- T cells from miR-149-3p reverses CD8+ T-cell exhaustion by reducing inhibitory receptors and promoting cytokine secretion in breast cancer cells

Meng Zhang Dian Gao Yanmei Shi Yifan Wang Rakesh Kumar Joshi

Blockade of inhibitory receptors (IRs) is one of the most effective immunotherapeutic approaches to treat cancer. Dysfunction of miRNAs is a major cause of aberrant expression of IRs and contributes to the immune escape of cancer cells. How miRNAs regulate immune checkpoint proteins in breast cancer remains largely unknown. In this study, downregulation of miRNAs was observed in PD-1-overexpressing CD8+ T cells using miRNA array analysis of mouse breast cancer homografts. The data reveal that miR-149-3p was predicted to bind the 3'UTRs of mRNAs encoding T-cell inhibitor receptors PD-1, TIM-3, BTLA and Foxp1. Treatment of CD8+ T cells with an miR-149-3p mimic reduced apoptosis, attenuated changes in mRNA markers of T-cell exhaustion and downregulated mRNAs encoding PD-1, TIM-3, BTLA and Foxp1. On the other hand, T-cell proliferation and secretion of effector cytokines indicative of increased T-cell activation (IL-2, TNF-α, IFN-γ) were upregulated after miR-149-3p mimic treatment. Moreover, the treatment with a miR-149-3p mimic promoted the capacity of CD8+ T cells to kill targeted 4T1 mouse breast tumour cells. Collectively, these data show that miR-149-3p can reverse CD8+ T-cell exhaustion and reveal it to be a potential antitumour immunotherapeutic agent in breast cancer.

BTLA

10.6084/m9.figshare.9896825.v1

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Poster 469 A Variant of Motor Neuron Disorder: Hirayama Disease: A Case Report

PM&R (2016)

Hongmei Wang Yuxi Chen

Center (category theory)

10.1016/j.pmrj.2016.07.390

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Tumor size as a prognostic factor in patients with node-negative gastric cancer invading the muscularis propria and subserosa (pT2-3N0M0 stage).

PubMed (2013)

Chang‐Ming Huang Hongmei Wang Chao‐Hui Zheng Ping Li Jian‐Wei Xie

To explore the impact of tumor size on outcomes in patients with pT2-3N0M0 stage.ROC curve analysis was used to determine the appropriate cut-off value for tumor size in 115 patients of pT2-3N0M0 stage gastric cancer. Based on this cut-off value, patients were divided into two groups. The five-year overall survival (OS) rates in the two groups were compared according to the independent prognostic factors.Using this cut-off value of 3.7cm, 62 patients had large-sized tumors (LSTs, tumor size >3.7cm) and 53 had small-sized tumors (SSTs, tumor size <3.7cm). Patients with LSTs had a significantly lower five-year OS rate than those with SSTs (60.7% vs. 88.4%, p=0.000). Depth of tumor invasion, histological type and tumor size were independent prognostic factors. In patients with pT2N0M0 stage tumors or pT2-3N0M0 stage patients with undifferentiated type tumors, five-year OS rates were significantly lower for LSTs than for SSTs (p<0.05 each).Tumor size is a prognostic factor in patients with pT2-3N0M0 stage. Especially for pT2N0M0 stage gastric cancer and pT2-3N0M0 stage gastric cancer with undifferentiated type tumors, the prognosis was poorer in patients with tumor size >3.7cm than that in patients with tumor size <3.7cm.

Tumor stage

T-stage

10.5754/hge12733

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Enhancement of the cytotoxic effect of cytokine induced killers by dendritic cells pulsed with astragalus polysaccharides.

Zhongguo mianyixue zazhi (2009)

Song Zhang Xiao-Yan Mu Hongmei Wang Shujuan Jiang

Astragalus

Source

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Incidental Receipt of Cardiac Medications and Survival Outcomes Among Patients With Stage III Non–Small-Cell Lung Cancer After Definitive Radiotherapy

Clinical Lung Cancer (2014)

Hongmei Wang Zhongxing Liao Yan Zhuang Ying Liu Lawrence B. Levy

Receipt

10.1016/j.cllc.2014.09.006

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Citations (34)

Gene silencing of indoleamine 2,3-dioxygenase hinders tumor growth through angiogenesis inhibition

International Journal of Oncology (2017)

Jinfeng Pan Keng Yuan Shanshan Peng Yanqin Huang Yujuan Zhang

The significance of indoleamine 2,3-dioxygenase-1 (IDO1) has been studied in various types of tumors, but the relationship between IDO1 and tumor angiogenesis needs further delineation. We aimed to clarify the relationship between tumor angiogenesis and IDO1 expression, and to explore the possibility of IDO1-targeting molecular therapy for lung cancer. For the first time, we found that silencing the IDO1 gene using small interfering RNA (siRNA) inhibits in vitro cancer cell invasion and migration. We further demonstrated that knockdown of IDO1 decreased the formation of vasculogenic mimicry. In addition to these in vitro findings, we also demonstrated that in vivo IDO1 gene silencing using short hairpin RNA (shRNA) delayed tumor onset and inhibited tumor growth in the mouse model. Immunostaining showed that IDO1 gene silencing inhibited tumor angiogenesis. Moreover, the expression of IDO1 was associated with microvessel density (MVD) labeled by CD34 and CD146. These findings indicate that IDO1 has the potential to participate in or contribute to the formation of new capillaries, supporting the applicability of IDO1-targeting molecular therapy in lung cancer.

Indoleamine 2,3-dioxygenase

10.3892/ijo.2017.3975

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Citations (18)

CCDC 673038: Experimental Crystal Structure Determination

The Cambridge Structural Database (2008)

Xiao‐Hua Zeng Hongmei Wang Aihua Zheng Jia-Hua Tian Ting-Yun He

An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.

10.5517/ccqlbxj

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CCDC 840932: Experimental Crystal Structure Determination

The Cambridge Structural Database (2012)

Jun Zhang Yun‐Shan Xue Hongmei Wang Min Fang Hong‐Bin Du

10.5517/ccx71v0

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Research on Aging of Population and the Sustainable Development

Asian Social Science (2010)

Hongmei Wang

When the new century arrives, our country also started to step into ranks of the old age type country following up some developed countries, and the step of aging of population is being accelerated unceasingly. Aging of population is one kind of inevitable trend, with both opportunities and challenges. The key is how to seize the opportunities, meet the challenges, respond to aging of population, and promote sustainable development. This paper has brought forward countermeasures from the following four aspects: population policy, retirement pension system, developing human resources of the old and accelerating society economy development.

Population Ageing

Aged population

10.5539/ass.v6n12p206

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Citations (4)