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Jessica Matesanz-Isabel

Instituto de Biomedicina y Genética Molecular de Valladolid

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Pablo Engel

Universitat de Barcelona

Javier Álvarez

Instituto de Biomedicina y Genética Molecular de Valladolid

Jordi Sintes

Hospital Del Mar

Mayte Montero

Consejo Superior de Investigaciones Científicas

José de Salort

Universitat de Barcelona

Rosalba I. Fonteríz

Universidad de Valladolid

Laia Llinàs

Leitat Technological Center

Adriana Lázaro

Universitat de Barcelona

Jessica Arias-del-Val

Instituto de Biomedicina y Genética Molecular de Valladolid

Pilar Álvarez-Illera

Universidad de Valladolid

Cooperative Institutions

Instituto de Biomedicina y Genética Molecular de Valladolid

Consejo Superior de Investigaciones Científicas

Universidad de Valladolid

Universitat de Barcelona

Consorci Institut D'Investigacions Biomediques August Pi I Sunyer

Unidades Centrales Científico-Técnicas

Universidad Autónoma de Madrid

Departament de Salut

Oncomedics (France)

Christ Hospital

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Expression of SLAM (CD150) cell-surface receptors on human B-cell subsets: From pro-B to plasma cells

Immunology Letters (2010)

José de Salort Jordi Sintes Laia Llinàs Jessica Matesanz-Isabel Pablo Engel

Memory B cell

Naive B cell

B-1 cell

10.1016/j.imlet.2010.09.021

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Citations (63)

Functional roles of MICU1 and MICU2 in mitochondrial Ca 2+ uptake

Biochimica et Biophysica Acta (BBA) - Biomembranes (2016)

Jessica Matesanz-Isabel Jessica Arias-del-Val Pilar Álvarez-Illera Rosalba I. Fonteríz Mayte Montero

Uniporter

10.1016/j.bbamem.2016.02.022

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Citations (43)

Modulation of Calcium Entry by Mitochondria

Advances in experimental medicine and biology (2016)

Rosalba I. Fonteríz Jessica Matesanz-Isabel Jessica Arias-del-Val Pilar Alvarez-Illera Mayte Montero

Uniporter

Organelle

Calcium Signaling

10.1007/978-3-319-26974-0_17

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Citations (22)

Expression profiles of novel cell surface molecules on B-cell subsets and plasma cells as analyzed by flow cytometry

Immunology Letters (2010)

Laia Llinàs Adriana Lázaro José de Salort Jessica Matesanz-Isabel Jordi Sintes

Cluster of differentiation

10.1016/j.imlet.2010.10.009

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Citations (40)

Dynamics of mitochondrial Ca2+ uptake in MICU1-knockdown cells

Biochemical Journal (2013)

Sergio de la Fuente Jessica Matesanz-Isabel Rosalba I. Fonteríz Mayte Montero Javier Álvarez

MICU1 (Ca2+ uptake protein 1, mitochondrial) is an important regulator of the MCU (Ca2+ uniporter protein, mitochondrial) that has been shown recently to act as a gatekeeper of the MCU at low [Ca2+]c (cytosolic [Ca2+]). In the present study we have investigated in detail the dynamics of MCU activity after shRNA-knockdown of MICU1 and we have found several new interesting properties. In MICU1-knockdown cells, the rate of mitochondrial Ca2+ uptake was largely increased at a low [Ca2+]c (<2 μM), but it was decreased at a high [Ca2+]c (>4 μM). In the 2-4 μM range a mixed behaviour was observed, where mitochondrial Ca2+ uptake started earlier in the MICU1-silenced cells, but at a lower rate than in the controls. The sensitivity of Ca2+ uptake to Ruthenium Red and Ru360 was similar at both high and low [Ca2+]c, indicating that the same Ca2+ pathway was operating in both cases. The increased Ca2+-uptake rate observed at a [Ca2+]c below 2 μM was transient and became inhibited during Ca2+ entry. Development of this inhibition was slow, requiring 5 min for completion, and was hardly reversible. Therefore MICU1 acts both as a MCU gatekeeper at low [Ca2+]c and as a cofactor necessary to reach the maximum Ca2+-uptake rate at high [Ca2+]c. Moreover, in the absence of MICU1, the MCU becomes sensitive to a slow-developing inhibition that requires prolonged increases in [Ca2+]c in the low micromolar range.

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Ruthenium red

10.1042/bj20131025

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New B-cell CD molecules

Immunology Letters (2010)

Jessica Matesanz-Isabel Jordi Sintes Laia Llinàs José de Salort Adriana Lázaro

Naive B cell

10.1016/j.imlet.2010.09.019

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Citations (68)