Bárbhara Mota Marinho

Universidade Estadual de Montes Claros

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Sérgio Henrique Sousa Santos

Universidade Estadual de Montes Claros

Victor Hugo Dantas Guimarães

Universidade Estadual de Montes Claros

Vívian Machado Benassi

Universidade Federal dos Vales do Jequitinhonha e Mucuri

Alfredo Maurício Batista de Paula

Universidade Estadual de Montes Claros

André Luiz Sena Guimarães

Universidade Estadual de Montes Claros

David Lee Nelson

Universidade Federal dos Vales do Jequitinhonha e Mucuri

Theles de Oliveira Costa

Universidade Federal de Minas Gerais

Tarcísio Michael Ferreira Soares de Oliveira

Departamento de Ciência e Tecnologia

Geraldo Aclécio Melo

Universidade Estadual de Montes Claros

Sidnei Tavares dos Reis

Universidade Federal de Minas Gerais

Cooperative Institutions

Universidade Federal de Minas Gerais

Universidade Federal dos Vales do Jequitinhonha e Mucuri

Universidade Estadual de Montes Claros

Universidade Federal de Lavras

Universidade de São Paulo

Instituto Federal de Educação Ciência e Tecnologia do Norte de Minas Gerais

Weatherford College

Universidade de Ribeirão Preto

Universidade Estadual de Campinas (UNICAMP)

Universidade Federal de Viçosa

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Phytochemical profile and antiproliferative activity of human lymphocytes of Gomphrena virgata Mart. (Amaranthaceae)

Natural Product Research (2021)

Bárbhara Mota Marinho Débora Nunes Fernandes Mayara Zimmermann Chicoti Giovane de Jesus Gomes Ribeiro Valéria Gomes de Almeida

Gomphrena virgata Mart. popularly known as 'Cangussu-branco', is used in Brazilian folk medicine to treat inflammations and infections. This work aimed to carry out phytochemical analysis and evaluate the anti-inflammatory potential of Gomphrena virgata. In the phytochemical investigation, in addition to the presence of two ecdysteroids, 20 R-dihydroxyecdysone and 20-hydroxyecdysone, identified by HPLC-PDA-MS and NMR, 22 compounds were identified by GC-MS. In the cytotoxicity study, the aqueous extract of the roots of this species did not show in vitro toxicity of PBMCs in the concentrations of 250, 500 and 1000 µg/mL when analyzed by the trypan blue exclusion method. Also, it was effective in reducing lymphocyte proliferation, stimulated with the mitogen PHA, by 26.02%, 48.57% and 50.49% when compared to dexamethasone, respectively. In this work we present information about the phytochemicals of G. virgata, showing that the species is promising in obtaining compounds with medicinal potential mainly anti-inflammatory potential.

Phytochemical

Amaranthaceae

Trypan blue

10.1080/14786419.2021.1895151

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PRODUÇÃO DE CELULASES POR FUNGOS FILAMENTOSOS ISOLADOS NO NORTE DE MINAS GERAIS CULTIVADOS EM MEIO DE CULTURA CONTENDO RESÍDUOS DE BANANEIRA

Adriele Mercia Alves Santos Bárbhara Mota Marinho Vívian Machado Benassi

10.22533/at.ed.7911925048

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PADRONIZAÇÃO DO CULTIVO DO Aspergillus sp. M2.3 PARA PRODUÇÃO DE AMILASE E CARACTERIZAÇÃO BIOQUÍMICA DA ENZIMA

Izabela Nascimento Silva Tarcísio Michael Ferreira Soares de Oliveira Alice Gomes Miranda Bárbhara Mota Marinho Vívian Machado Benassi

10.22533/at.ed.39420220112

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O LIXO QUE NÃO QUEREMOS PRÁTICAS SOCIOAMBIENTAIS NO MEIO ACADÊMICO DO IECT-JANAÚBA E ESCOLA ESTADUAL JOAQUIM MAURÍCIO DE AZEVEDO

Anais do Congresso Brasileiro Interdisciplinar em Ciência e Tecnologia. (2021)

Adriana da Silva Souza Eugênio Nunes Silva Brito Karine Silva Bárbhara Mota Marinho

10.29327/143026.2-81

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Hydroalcoholic Extract of Solanum lycocarpum A. St. Hil. (Solanaceae) Leaves Improves Alloxan-Induced Diabetes Complications in Mice

Protein and Peptide Letters (2021)

Victor Hugo Dantas Guimarães Jéssica Nayara Basílio Silva Daniela Fernanda de Freitas Otávio Cardoso Filho Luiz Henrique da Silveira

Background:: Solanum lycocarpum is a medicinal plant used in Brazil with hypoglycemic activity by its fruits use. However, the fruits production is restricted in some periods of the year, differently of leaves. Objective:: To evaluate the effects of hydroalcoholic extracts of S. lycocarpum leaves in alloxan-induced diabetic mice. Methods:: Hydroalcoholic extract of S. lycocarpum was characterized by phytochemical and GCMS analysis. The Antidiabetic activity was assessed following treatment for 22 days with S. lycocarpum extract at 125, 250, and 500 mg/kg. Bodyweight, water, and food intake, glycemia, biochemical parameters, anatomy-histopathology of the pancreas, liver and kidney, and expression of target genes were analyzed. In addition, oral acute toxicity was evaluated. Results:: Animals treated showed a significant reduction (p < 0.05) in glycemia following a dose of 125 mg/kg. Food intake remained similar for all groups. Decreased polydipsia symptoms were observed after treatment with 250 (p < 0.001) and 500 mg/kg (p < 0.01) compared with diabetic control, although normal rates were observed when 125 mg/kg was administered. A protective effect was also observed in the pancreas, liver, and kidneys, through the regeneration of the islets. Hypoglycemic activity can be attributed to myo-inositol, which stimulates insulin secretion, associated with α-tocopherol, which prevents damage from oxidative stress and apoptosis of β-pancreatic cells by an increased Catalase (CAT) and Glutathione peroxidase 4 (GPX4) mRNA expression. The toxicological test demonstrated safe oral use of the extract under the present conditions. Conclusion:: Hydroalcoholic extract of S. lycocarpum promotes the regulation of diabetes in the case of moderate glycemic levels, by decreasing glycemia and exerting protective effects on the islets.

Alloxan

Phytochemical

10.2174/0929866528999210128205817

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PRODUÇÃO DE CELULASES E FORMAÇÃO DE AÇÚCARES FERMENTESCÍVEIS PELA DEGRADAÇÃO DO BAGAÇO DE CANA-DE-AÇÚCAR

Ciência & Tecnologia Fatec-JB (2017)

Tarcísio Michael Ferreira Rosa Bárbhara Mota Marinho Vívian Machado Benassi

A prospeccao por micro-organismos produtores de enzimas celuloliticas tem sido o foco de muitos estudos com o interesse de utilizar residuos agricolas na producao de etanol celulosico. Desta forma, este trabalho objetivou selecionar um fungo filamentoso potencial produtor de celulase isolados no norte de Minas Gerais, alem de determinar as melhores condicoes da fermentacao submersa para producao de celulase. Os 6 (seis) fungos filamentosos isolados da palha da cana-de-acucar foram caracterizados macro e microscopicamente e submetidos ao screening para a producao da enzima FPase. O Aspergillus 3.7TA foi selecionado para avaliacao dos melhores parâmetros para a producao de FPase, CMCase e Avicelase. Para determinacao do melhor meio de cultura, avaliou-se os meios: Khanna modificado, SR modificado, Czapeck, e CP. Analisou-se tambem o efeito de diferentes solucoes de sais: sais do proprio meio CP; sais do meio SR; sais Wesson acrescido dos sais do meio CP; e sais Wesson, o efeito de diferentes fontes de nitrogenio (extrato de levedura e peptona), o tempo (dias) de crescimento fungico e diferentes fontes de carbono no crescimento e na producao enzimatica. Todas as fermentacoes submersas foram conduzidos a 30°C de forma estacionaria e a determinacao da atividade FPase, CMCase e Avicelase foram determinadas pela formacao de acucares redutores segundo Miller (1959). Observou-se que o Aspergillus 3.7TA apresentou melhor producao celulolitica em meio CP associado com sais Welson, empregando o extrato de levedura e o farelo de trigo como fonte de nitrogenio e de carbono, respectivamente, durante 6 (seis) dias, a 30°C, de forma estacionaria.

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Oral treatment with Davilla Elliptica A. St,-Hil. leaves improves liver steatosis and lipid metabolism on a diet-induced obese mice model

Phytomedicine Plus (2021)

Jaciara Neves Sousa Valéria Mafra Bárbhara Mota Marinho Victor Hugo Dantas Guimarães Luís Paulo Oliveira

Davilla elliptica A. St.-Hil, also known as "lixeirinha or sambaibinha" is a shrub belonging to the Dilleniaceae family that occurs naturally in the Brazilian savannah (Cerrado). Research studies have shown evidence of its gastroprotective effect, as well as its benefits as an anti-nociceptive, anti-inflammatory, and antioxidant. However, there are no studies testing the potential effects of D. elliptica on treating metabolic parameters and obesity. The aim of the present study was to investigate D. elliptica effects on hepatic steatosis induced by a high-fat/high-sugar diet. Animal experimentation was performed using male Swiss mice divided into four groups: ST (standard control), HLHS (obese control), HLHS+EAF (ethyl-acetate fraction), and HLHS+PL (leaf powder). The groups were treated for four weeks with 0.26 mg/kg/body weight. The main findings of the present study showed that D. elliptica reduced hepatic lipid deposition, body weight, triglycerides, and total cholesterol levels. Gene expression analysis showed that GPX4 and PPARγ mRNA were significantly suppressed in HLHS + EAF mice livers. The present study contributes to elucidating the D. elliptica metabolic role in decreasing GPX4 and PPARγ expression in the HLHS group.

Steatosis

10.1016/j.phyplu.2021.100130

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Brazilian arnicas: bioactive compounds, pharmacological properties, potential use and clinical applications

Phytochemistry Reviews (2023)

Bárbhara Mota Marinho Caroline Honaiser Lescano Sérgio Henrique Sousa Santos

10.1007/s11101-023-09884-x

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Nutritional implications in the mechanistic link between the intestinal microbiome, renin-angiotensin system, and the development of obesity and metabolic syndrome

The Journal of Nutritional Biochemistry (2022)