Expanded bed adsorption is a new technique using stable homogeneous fluidization for initial recovery of a product from crude fermentation broth. The technique makes it possible to combine clarification, concentration and product capture in one unit operation. This study shows a 144 fold scale-up from laboratory to production scale. The column sizes used are 50 mm I.D. and 600 mm I.D. respectively. Residence time distribution (RTD), the response from an injected step, was used to evaluate the scale up. This reflects the hydrodynamics of the system. Adsorption kinetics was determined from a breakthrough curve of bovine serum albumine and the binding capacity was calculated. The results show that expanded bed adsorption is scaleable from laboratory to production scale with retained properties.
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