I. E. Wasserlauf

National Research Tomsk State University

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V. N. Stegniy

National Research Tomsk State University

Anuarbek K. Sibataev

S.Seifullin Kazakh Agro Technical University

Svetlana Alexeeva

National Research Tomsk State University

Tatyana Anan’ina

National Research Tomsk State University

Gulnar Abylkassymova

Institute of Plant Biology and Biotechnology

КЕ

К. Е. Усов

National Research Tomsk State University

K. E. Usov

National Research Tomsk State University

Marina Kudabaeva

National Research Tomsk State University

Marina Khodanovich

National Research Tomsk State University

Vasily L. Yarnykh

University of Washington

Cooperative Institutions

National Research Tomsk State University

Russian Academy of Sciences

Academy of Medical Sciences

Tomsk National Research Medical Center

Siberian State Medical University

Institute of Cytology and Genetics

University of Washington

Siberian Branch of the Russian Academy of Sciences

Research Institute of Pharmacology and Regenerative Medicine named ED Goldberg

Institute of Pharmacology

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Long-Term and Seasonal Dynamics of Inversion Polymorphism of the Malaria Mosquito <i>Anopheles messeae</i> Fall. (Diptera: Culicidae) in the Population of the Central Part of the Species Range (Western Siberia, Tomsk Region)

Генетика (2023)

Anuarbek K. Sibataev I. E. Wasserlauf K. E. Usov Svetlana Alexeeva Gulnar Abylkassymova

Polytene chromosome

Chromosomal inversion

Chromosomal polymorphism

10.31857/s0016675823020121

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Citations (0)

Specific features in linear and spatial organizations of pericentromeric heterochromatin regions in polytene chromosomes of the closely related species Drosophila virilis and D. kanekoi (Diptera: Drosophilidae)

Genetica (2015)

I. E. Wasserlauf К. Е. Усов Gleb N. Artemov Tatyana Anan’ina V. N. Stegniy

Polytene chromosome

Drosophila virilis

Constitutive heterochromatin

Chromosome regions

Euchromatin

10.1007/s10709-015-9832-7

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Citations (1)

Comparative analysis of the variability of the genetic structure of Anopheles messeae (Diptera, Culicidae) populations from Western Siberia and Eastern Kazakhstan

IOP Conference Series Earth and Environmental Science (2019)

Gulnar Abylkassymova I. E. Wasserlauf Anuarbek K. Sibataev V. N. Stegniy Yu. V. Andreeva

Abstract A comparison of the species composition of anopheles mosquitoes from the East Kazakhstan region and the south of Western Siberia has been carried out. A comparative cytogenetic analysis of An. messeae larvae from the southern and central parts of the range was done. The tendency of displacement of the “south-eastern” genocomplexes from the center of the An. messeae habitat to its southern borders has been observed.

10.1088/1755-1315/400/1/012013

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Biomedicines (2023)

Marina Khodanovich М. В. Светлик Anna Naumova Daria Kamaeva А. В. Усова

Age-related myelination decrease is considered one of the likely mechanisms of cognitive decline. The present preliminary study is based on the longitudinal assessment of global and regional myelination of the normal adult human brain using fast macromolecular fraction (MPF) mapping. Additional markers were age-related changes in white matter (WM) hyperintensities on FLAIR-MRI and the levels of anti-myelin autoantibodies in serum. Eleven healthy subjects (33–60 years in the first study) were scanned twice, seven years apart. An age-related decrease in MPF was found in global WM, grey matter (GM), and mixed WM–GM, as well as in 48 out of 82 examined WM and GM regions. The greatest decrease in MPF was observed for the frontal WM (2–5%), genu of the corpus callosum (CC) (4.0%), and caudate nucleus (5.9%). The age-related decrease in MPF significantly correlated with an increase in the level of antibodies against myelin basic protein (MBP) in serum (r = 0.69 and r = 0.63 for global WM and mixed WM–GM, correspondingly). The volume of FLAIR hyperintensities increased with age but did not correlate with MPF changes and the levels of anti-myelin antibodies. MPF mapping showed high sensitivity to age-related changes in brain myelination, providing the feasibility of this method in clinics.

Fluid-attenuated inversion recovery

Caudate nucleus

Grey matter

10.3390/biomedicines12010061

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Citations (3)

Russian Journal of Genetics (2003)

I. E. Wasserlauf

Synapsis

Chromosome pairing

Dysgenesis

10.1023/a:1023739918676

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Citations (1)

Marina Khodanovich М. В. Светлик Anna Naumova Daria Kamaeva А. В. Усова

Age-related myelination decrease is considered one of the likely mechanisms of cognitive decline. The present study is based on the longitudinal assessment of global and regional myelination of the normal adult human brain using the fast macromolecular fraction (MPF) mapping. Additional markers were age-related changes in white matter (WM) hyperintensities on FLAIR-MRI and the levels of anti-myelin autoantibodies in serum. Eleven healthy subjects (33–60 years in the first study) were scanned twice, 7 years apart. An age-related decrease in MPF was found in global WM, GM, and mixed WM-GM, as well as in 48 out of 82 examined WM and GM regions. The greatest decrease in MPF was observed for the frontal WM (2-5%), genu of the corpus callosum (CC) (4.0%) and caudate nucleus (5.9%). The age-related decrease in MPF significantly correlated with an increase in the level of antibodies against myelin basic protein (MBP) in serum (r = 0.69 and r = 0.63 for global WM and mixed WM-GM, correspondingly). The volume of FLAIR hyperintensities increased with age but did not correlate with MPF changes and the levels of anti-myelin antibodies. MPF mapping showed high sensitivity to age-related changes in brain myelination, providing the feasibility of this method in clinics.

Fluid-attenuated inversion recovery

Caudate nucleus

10.20944/preprints202311.0496.v1

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Citations (3)