F. Hervás

Hospital Clínico San Carlos

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Jesús Argente

Universidad Autónoma de Madrid

Vicente Barrios

Hospital Infantil Universitario Niño Jesús

V. Pozuelo

Centro de Investigaciones Biológicas Margarita Salas

Francisco Escobar del Rey

Consejo Superior de Investigaciones Científicas

Gabriella Morreale de Escobar

King Faisal Specialist Hospital & Research Centre

J.M. Tanner

Michael O. Thorner

University of Virginia

Jesús Pozo

Hospital Infantil Universitario Niño Jesús

Morey W. Raymond

Nemours Children’s Clinic

Montserrat Puente

Hospital San Pedro

Cooperative Institutions

Universidad Autónoma de Madrid

Hospital Infantil Universitario Niño Jesús

Instituto de Salud Carlos III

Consejo Superior de Investigaciones Científicas

Universidad Complutense de Madrid

University of Tsukuba

Hospital Clínico San Carlos

Hospital Universitario Reina Sofía

Middlesex Hospital

Centro de Investigación Biomédica en Red

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Effects of l-thyroxine treatment on pituitary GH content of adult rats with neonatal thyrotoxicosis

European Journal of Endocrinology (1983)

A. M. Pascual-Leone EC Besa F. Hervás Fernando Escrivá Carmen Álvarez

Abstract. Rats receiving large doses of thyroxine (30 μg/5 doses) during their first days of life develop an apparently permanent alteration of the hypothalamus-pituitary-thyroid complex. This neonatal thyrotoxicosis has been called neo-T 4 syndrome. A state of permanent but not very severe hypothyroidism seems to be induced, accompanied by a decrease in pituitary GH content at least until day 22. In this work, growth hormone content has been measured by a specific radioimmunoassay in the anterior pituitary of 45 and 78 day old neo-T 4 and control (saline-injected) rats. GH content of the adult neo-T 4 treated animals was significantly lower than that of the adult controls. Administration of different doses of T 4 (1.7 μg/100 g body weight/3 doses or 2.5 μg/100 g body weight/8 doses, to 70 day old rats, and 5 μg/100 g body weight/3 doses to 42 day old rats) to adult neo-T 4 rats did not alter these decreased pituitary GH levels. This differs from hypothyroid rats, in which T 4 administration has been shown to increase pituitary GH content. A third approach was to thyroidectomize neo-T 4 and control rats and administer 5 μg T 4 /100 g body weight, which produced the same increase in pituitary GH in both groups of animals. These results seem to indicate that changes in pituitary GH content of neo-T 4 rats are not due to hypothyroidism. Thus, it would appear that treatment with large T 4 doses during the early perinatal period not only deranges the hypothalamic-pituitary-thyroid axis but other pituitary functions as well.

10.1530/acta.0.1040340

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Citations (1)

Normative data for insulin-like growth factors (IGFs), IGF-binding proteins, and growth hormone-binding protein in a healthy Spanish pediatric population: age- and sex-related changes.

The Journal of Clinical Endocrinology & Metabolism (1993)

Jesús Argente Vicente Barrios Jesús Pozo M.T. Muñoz F. Hervás

The normal values of insulin-like growth factors (IGFs) after extraction, their binding proteins, and the high affinity GH-binding protein are not well established in infancy or childhood. We report the relationship between serum IGF-I, IGF-II, their binding proteins IGFBP-1 and IGFBP-3, and GH-binding protein in 600 normal Spanish children who were divided into 5 groups according to Tanner stage: I, 150 males and 102 females; II, 40 males and 42 females; III, 45 males and 45 females; IV, 42 males and 55 females; and V, 23 males and 56 females. Serum IGF-I levels increase slowly during childhood in both sexes, exhibiting a dramatic increase during puberty and a significant decline [P < 0.001, by analysis of variance (ANOVA)] during adulthood. The pubertal peak occurs approximately 2 yr earlier in girls than in boys. In contrast, serum IGF-II levels remain stable throughout childhood, showing no pubertal peak. In boys, there is a significant decline in IGF-II levels during adulthood (P < 0.001). Serum IGFBP-3 levels show a pattern similar to that of IGF-I, with a significant increase during childhood and a significant decline during adulthood (P < 0.001, ANOVA) in both males and females. In contrast, serum IGFBP-1 levels decrease dramatically during childhood in both boys and girls (P < 0.001 and P < 0.005, respectively, by ANOVA). A significant decline in serum GH-binding protein levels is observed between prepubertal and pubertal children of both sexes (P < 0.001). There is a close linear correlation between the sum of serum IGF-I plus IGF-II levels vs. serum IGFBP-3 (r = 0.724; P < 0.0001). In contrast, there is a nonlinear correlation between serum IGF-I vs. serum IGFBP-3 (concave curve) as well as between serum IGF-II and serum IGFBP-3 (convex curve). A negative correlation was found between serum IGF-I vs. IGFBP-1 (r = -0.51; P < 0.0001) as well as between the sum of serum IGF-I plus IGF-II vs. IGFBP-1 (r = -0.47; P < 0.0001), but not between serum IGF-II and IGFBP-1. These data emphasize that when these tests are performed in the clinic, their interpretation should be based upon age- and sex-specific criteria.

10.1210/jcem.77.6.7505288

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[Secretion of growth hormone in hyperthyroidism].

PubMed (1976)

F. Hervás Morreale de Escobar G Escobar Del Rey F Pozuelo

The authors studied growth hormone (GH) secretion in a group of adult controls and another group of hyperthyroid patients after stimulation with intravenous insulin-induced (0,1 IU/kg) hypoglycemia, aiming to clear out the problem of discrepancies in literature concerning GH secretion in hyperthyroidism. They concluded that in this syndrome, GH levels are significantly higher than those of controls. The GH releasing response is normal, though it could be expected to be decreased due to decreased pituitary GH contents as a result of permanent somatotrophic cell stimulation.

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Testosterone response to human chorionic gonadotrophin in patients undergoing long term treatment with a gonadotrophin-releasing hormone superagonist analogue (decapeptyl)

Journal of Steroid Biochemistry (1986)

Sergio Donnay J. A. García Centenera J. Faraoso F. Hervás Enrique Caso

Human chorionic gonadotropin

10.1016/0022-4731(86)90823-x

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A Rapid Procedure for the Radioimmunoassay of Rat Growth Hormone

Hormone and Metabolic Research (1974)

F. Hervás G. Morreale de Escobar

The radioimmunoassay for rat GH may be improved and the time required for its completion shortened by adding the labeled GH 6 hr after onset of a 24 hr incubation period at 37°C. Several features are also described which decrease the time spent on a given assay, and results are shown which validate the shortening procedures.

Incubation period

10.1055/s-0028-1093833

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Rapid Effects of Single Small Doses of L-Thyroxine and Triiodo-L-thyronine on Growth Hormone, as Studied in the Rat by Radioimmunoassay¹

Endocrinology (1975)

F. Hervás Gabriella Morreale de Escobar Francisco Escobar del Rey

The effects of thyroid hormone deprivation and restitution on growth hormone (GH) economy have been studied in the rat by means of a specific radioimmunoassay. The pituitary GH content and the plasma GH levels before and during stimulation with pentobarbital ("PB-test") were studied in male rats at different intervals after surgical thyroidectomy (T), and in T rats at different time intervals after the ip injection of 0.20, 1.75, and 5.0 mug thyroxine (T4) or 0.05, 0.10, 0.20 and 1.0 mug triiodothyronine (T3), all doses being referred to 100 g body wt. Pituitary GH content decreased very rapidly after T, a difference being shown at the end of the shortest time interval studied (24 h); 24 days after T, pituitary GH content was 0.3 percent or less of the pre-T level, the basal plasma GH was lower than in intact controls and an increase in plasma GH during PB-stimulation was no longer observed. When rats T for 30 days or longer were injected once with T4 or T3, pituitary GH content increased; basal plasma GH levels increased also and a positive response to PB was observed. An effect on pituitary GH content could be observed as soon as 2 h after the ip injection of 1.0 mug T3, or 6 h after 5.0 mug T4. The "latent period" was somewhat longer when lower doses of the hormones were used. Effects of a single 0.10 mug T3 dose could be detected within 12 h L-T3 appeared to be at least 9 times more potent in vivo tha T4, as assessed from the effect on pituitary GH. The mea-urement by RIA of changes in GH content of the rat pituitary may thus provide the most adequate parameter available at present (other than suppression of TRH-induced TSH release) for a biological effect in vivo of single doses of the thyroid hormones, a measurement clearly related to an important physiological role.

Basal (medicine)

10.1210/endo-97-1-91

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Citations (177)

[H2-receptors and prolactin secretion. Effects of acute and chronic administration of cimetidine on subjects with normal and high levels of prolactin (author's transl)].

PubMed (1980)

García Centenera Ja Félix Requejo Alba Jp María Herrán Lucero Jl

Cimetidine

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Effect of Calcitriol on Insulin Secretion in Uraemia

Nephrology Dialysis Transplantation (1990)

J. M. Quesada Alejandro Martín‐Malo Josephine C. Santiago F. Hervás María E. Martinez

To evaluate the role of calcitriol on insulin secretion in uraemia, nine patients on maintenance haemodialysis, never treated with vitamin D nor with calcium-channel blockers, were studied. Baseline glucose, insulin, C peptide, calcium, intact PTH, and calcitriol serum values were measured, and after an oral load of 75 g glucose, insulin and C peptide were also determined at 15, 30, 45, 60, and 120 min. Following 14 days of treatment with oral calcitriol (0.5 μg/day), the same study protocol was applied. Serum calcitriol values, which were low as expected, increased after therapy, but did not reach the values observed in healthy controls. Despite no change in total serum calcium, intact PTH values decreased significantly (182 vs 88.3 ng/ml, P<0.003). Baseline serum insulin was significantly increased after calcitriol (7.5 vs 35 /μU/ml, P<0.001). Similarly, an enhancement in insulin secretion following calcitriol was observed at 15 min (34 vs 70, P<0.01) and 30 min (57 vs 96 /μU/ml, P<0.01). Computation of the total area under the curve confirmed these results. Changes in C peptide profile paralleled those described for insulin. These data confirm that vitamin D modulates pancreatic β-cell secretion and suggest that calcitriol may regulate insulin release in uraemic patients.

C-peptide

10.1093/ndt/5.12.1013

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Citations (35)

Changes in parameters of growth hormone and thyrotrophic hormone, and of thyroid function, during the early postnatal period in the rat.

PubMed (1978)

Pascual-Leone Am García F. Hervás

The body length, and the weight of the body, liver, kidney and brain have been measured daily in rats during the first 10 days after birth. The plasma and pituitary growth hormone and thyrotrophic hormone levels were also determined, as well as the thyroidal 127I content and the plasma PBI. This observation period comprises a critical stage during which administration of large doses of thyroid hormones result in a permanent derangement of the thyroid-pituitary interrelations, and impairment of body growth and pituitary GH economy. The rate of growth of body, liver and kidney has been found to decrease significantly from day 7th to 9th of post-natal age, later to increase again. The pattern of the changes observed in the plasma and pituitary GH levels during the same period might well account for the alterations in growth patterns. The rate of growth of the brain, however, is not decreased during this stage, and appears to be independent of the changes in GH economy. No clearcut pattern of changes was observed in plasma TSH level; the pituitary TSH and thyroidal 125I contents increased progressively during the entire observation period. Plasma from suckling rats often contained high concentrations of non identified iodinated compounds, which were not thyroid hormones. Results are discussed in terms of the possible relationships between thyroid hormone and GH economy during a critical developmental period.

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[Kidney and osseous responsiveness to PTH in a case of pseudohypoparathyroidism (author's transl)].

PubMed (1981)

Quesada Gómez Jm Jaime Guerrero F. Hervás Carmen M. Vázquez

A case of pseudohypoparathyroidism is described, finding in addition to the typical clinical data described in the literature an all almost total atrophy of the minor lips and clitoris, a perforated hymen and a "paradoxical" increase of convulsions with anticomicial treatment. Study of response of urinary phosphates and AMPc to PTH, was negative (Drezner type I). Osseous response to PTH was negative (Frame type I pseudohypoparathyroidism). Pathogenic possibilities are discussed.

Pseudohypoparathyroidism

Clitoris

Hymen

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