Ivan Sitkin

Endocrinology Research Center

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Zhanna Belaya

Endocrinology Research Center

ИИ

И. И. Дедов

Endocrinology Research Center

ГА

Г. А. Мельниченко

Endocrinology Research Center

Liudmila Rozhinskaya

Endocrinology Research Center

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Д Г Курбатов

Endocrinology Research Center

Patimat Khandaeva

Endocrinology Research Center

Sergey Dubsky

National Medical Research Center of Cardiology

Larisa Dzeranova

Endocrinology Research Center

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А. М. Лапшина

Endocrinology Research Center

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Е И Марова

Endocrinology Research Center

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Endocrinology Research Center

Ministry of Health of the Russian Federation

Faculdades Guarulhos

Russian Academy of Sciences

National Medical Research Center of Cardiology

Sechenov University

Academy of Medical Sciences

University of Catania

Ural State Medical University

State Research Center of the Russian Federation

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Plasma microRNA expression in patients with Cushing's disease differs from ACTH-ectopic Cushing's syndrome

Endocrine Abstracts (2018)

Zhanna Belaya Patimat Khandaeva А. Г. Никитин Alexander Solodovnikov Ivan Sitkin

Searchable abstracts of presentations at key conferences in endocrinology ISSN 1470-3947 (print) | ISSN 1479-6848 (online)

Ectopic expression

Cushing Disease

Cushing's disease

10.1530/endoabs.56.oc8.1

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The comparative analysis of the results of clinical and hormonal investigations in the patients presenting with ACTH-producing neuroendocrine tumours

Problems of Endocrinology (2013)

Е И Марова Svetlana Arapova Г. С. Колесникова Ivan Sitkin Н. П. Гончаров

This study included the patients presenting with neuroendocrine tumours (NET) and the clinical picture of hypercoticism caused by excessive ACTH secretion from the tumour. The overwhelming majority of the patients (85%) suffered Cushing's disease (CD) associated with a pituitary tumour. The remaining 15% of the patients presented with ACTH-ectopic syndrome (ACTH-ES). The clinical picture of CD and ACTH-ES was very similar. The latter condition was associated with the higher plasma ACTH and cortisol levels as well as the free cortisol content in 24 hour urine and saliva samples collected in the evening compared with CD even though the differences were insignificant due to data scattering. Decompressin administration and catheterization of inferior petrosal sinuses caused a much greater enhancement of the ACTH level in the patients with CS in comparison with those suffering ASTH-ES.

Cushing Disease

ACTH secretion

10.14341/probl201359411-17

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Новая технология в хирургии патологического венозного дренажа кавернозных тел

Андрология и генитальная хирургия (2013)

Д Г Курбатов Лепетухин Александр Евгеньевич С. А. Дубский Ivan Sitkin

Venogenic erectile dysfunction (ED) is 20 to 60 % of all causes of erection problems. In most cases, the choice of surgical treatments depends on the degree and pattern of vascular disorders in the genesis of ED. The authors use the alternative treatment procedure X-ray endovascular occlusion of veins in the prostatic plexus. There is a significant improvement in the quality of erection in the first 3 months after surgery. The application of this innovative technology permits safe, mini-invasive and pathogenetically sound treatment for ED caused by abnormal venous drainage from the cavernous bodies.

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Сравнительный анализ данных клинических и гормональных исследований у пациентов с нейроэндокринными опухолями, продуцирующими АКТГ

Проблемы эндокринологии (2013)

Е И Марова Svetlana Arapova Г. С. Колесникова Ivan Sitkin Н. П. Гончаров

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Отдаленные результаты эндоваскулярного лечения критической ишемии нижних конечностей у пациентов с сахарным диабетом

Проблемы эндокринологии (2016)

А. М. Горбачева Zera N. Dzhemilova Г. Р. Галстян O. N. Bondarenko Н.Л. Аюбова

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Long-term prognosis of diabetic patients with critical limb ischemia after endovascular therapy

Problems of Endocrinology (2016)

А. М. Горбачева Zera N. Dzhemilova G. R. Galstyan O. N. Bondarenko N L Ayubova

Introduction. Critical limb ischemia (CLI) occurs approximately 20 times more frequently among diabetic patients. Frequency of amputations is higher too. Main treatment goal in these situations is in reconstruction of arterial blood flow with bypass surgery or endovascular interventions. Nevertheless, long-term prognosis of survival, limb preservation and life quality among Russian patients that underwent this therapy remains unclear, as well as influencing risk factors.The aim of the study was to evaluate the long-term prognosis in diabetic patients with critical limb ischemia (CLI) after peripheral angioplasty with active and nonactive follow-up period.Methods. 81 diabetic patients with CLI underwent PTA in 88 limbs. Patients were divided into 2 groups: group A (n = 51) – with active follow up (FU) period (visits every 3-6 months during 5 years) and group B (n = 30) - without active FU period (the second visit in our center was performed in 5 years after PTA). Diagnosis and treatment of CLI were based on recommendation of TASC II. The primary outcome was cumulative survival, secondary outcome were cases of repeat PTA and major amputations (MA) after 5 years after surgery.Results. Only 44 (86%) patients from group A finished FU period. There were 37 (46%) men, with mean age 64,1[54-68] years, mean HbA1c 7,9±1,4%, mean duration of diabetes 16,5[0,8-43] years, diabetes type 1/2 - 8/73 (90% of type 2). 82% had arterial hypertension, 5% - strokes, 18,5% - myocardial infarction. Chronical kidney disease of stage 1-2 was detected in 55,5%, stage 3-5 – in 30,8%. Anemia was diagnosed in 67,5%, arrhythmias – in 7,4%. 49,3% of patients suffered from diabetic retinopathy. Patients from both groups were comparable in comorbidities, severity of lower limb artery obstruction’s and degree of tissue damage (p<0,05): peripheral arterial disease (PAD) 4-6 classes according Graziani classification in both groups was in 75(93%) cases; Rutherford classification in both groups: 4 category-12(15%), 5category in 43(53%), and 6 category in 29(31%) patients. Repeat PTA was performed in group A in 15 (35%), in group B in 5(16%) cases. There were major amputations in groups: A-4(9%) vs group B – 4(12%) (log-rank, p<0,05). Cumulative survival in groups: A-80%, in group B-67%. (log-rank, p<0,05).Conclusion. CLI in diabetic patients is accompanied by different complications and is characterized by severe morphological lesions of the lower limbs arteries and soft tissue lesions. Active FU period have advantages in diabetic patients with CLI after PTA: timely done reinterventions with decrease the risk of major amputations and cumulative survival.

Critical limb ischemia

10.14341/probl201662528-29

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Prostatic Artery Embolization for Prostate Volume Greater Than 80 cm3: Results From a Single-center Prospective Study

Urology (2014)

Д Г Курбатов Giorgio Ivan Russo А. Е. Лепетухин Sergey Dubsky Ivan Sitkin

Single Center

10.1016/j.urology.2014.04.028

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THE STRATEGY FOR SURGICALLY MANAGING A NEUROISHEMIC TYPE OF DIABETIC FOOT SYNDROME.

Valeriy Afanas'evich Mitish Yu. S. Paskhalova С. Л. Соков Eroshkin Ia Александр Валентинович Ерошенко

Москва Неуклонный рост пациентов с синдромом диабетической стопы диктует необходимость качественно нового подхода к выбору стратегии комплексного хирургического лечения этой группы больных. До недавнего времени специализированная хирургическая помощь пациентам с гнойно-некротической стадией синдрома диабетической стопы заключалась в выполнении высоких ампутаций нижних конечностей, как правило, на уровне средней трети бедра, особенно при сочетании трофических изменений в тканях стопы с окклюзионно-стенотическим поражением магистральных артерий нижних конечностей. Однако внедрение принципов активного хирургического лечения гнойных ран, а также совершенствование методов эндоваскулярной хирургии позволяют сегодня стремиться к выполнению органосохраняющих операций у пациентов с синдромом диабетической стопы, осложненном гнойной инфекцией. За период 2006-2009гг. под нашим наблюдением находилось 78 пациентов с нейроишемической формой синдрома диабетической стопы (36 мужчин, 42 женщины). Средний возраст больных - 58,6±8,3 года. Объем поражения тканей стопы оценивался по классификации Wagner: 2-я стадия поражения стопы отмечалась у 7 (9,0%) пациентов, 3-я – у 22 (28,2%), 4-я – у 49 (62,8%), пациенты с 5-ой степенью поражения исключались из исследования в силу невозможности сохранения стопы. Влажный характер гнойно-некротического процесса наблюдался у 36 (46,2%) больных. Пациенты с сахарным диабетом 1 типа составили 14 (17,9%) человек. Среди сопутствующих осложнений у 47 пациентов отмечалось наличие диабетической ретинопатии, у 52 – диабетической нефропатии. В возрастной группе 50-75 лет отмечалось наличие сопутствующих ИБС, артериальной гипертензии, остаточных явлений ОНМК, язвенной болезни желудка. Обследование больных включало общеклинические, биохимические, бактериологические, морфологические, инструментальные методы диагностики (TcPO

Foot (prosody)

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Difference in plasma miRNA levels in inferior petrosal sinus samples from patients with ACTH-dependent Cushing’s syndrome as assessed by next-generation sequencing (NGS).

Endocrine Abstracts (2020)

Zhanna Belaya Anastasia A. Malygina А. Г. Никитин K Philipp Ivan Sitkin

Searchable abstracts of presentations at key conferences in endocrinology ISSN 1470-3947 (print) | ISSN 1479-6848 (online)

Plasma levels

10.1530/endoabs.70.aep569

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