Pilli V.V.N. Kishore

Amrita Institute of Medical Sciences and Research Centre

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C. W. Liu

National Dong Hwa University

Jian‐Hong Liao

National Dong Hwa University

Viswanathan Baskar

University of Hyderabad

Ananda Kumar Jami

GITAM University

Subramania Iyer

Amrita Institute of Medical Sciences and Research Centre

Yan-Ru Lin

National Dong Hwa University

Ravada Kishore

GITAM University

Sundeep Vijayaraghavan

Amrita Institute of Medical Sciences and Research Centre

Bharat Kumar Tripuramallu

Vignan's Foundation for Science, Technology & Research

E. Carolina Sañudo

Institut de Nanociència i Nanotecnologia de la Universitat de Barcelona

Cooperative Institutions

Amrita Institute of Medical Sciences and Research Centre

Amrita Vishwa Vidyapeetham

National Dong Hwa University

University of Hyderabad

Vignan's Foundation for Science, Technology & Research

GITAM University

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Aims Community College

Osmania University

Sugen Life Sciences (India)

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CCDC 984496: Experimental Crystal Structure Determination

The Cambridge Structural Database (2015)

Pilli V.V.N. Kishore Amaleswari Rasamsetty E. Carolina Sañudo Viswanathan Baskar

An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.

10.5517/cc121fyh

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Amrita Journal of Medicine (2025)

Sanju Samuel Pilli V.V.N. Kishore Jimmy Mathew Subramania Iyer

Abstract Background: Head and neck cancer (HNC) and its treatment have a huge impact on all aspects of patients’ quality of life (QOL) and their life satisfaction. QOL involves an individual’s subjective assessment of the impact of an illness or treatment on his/her physical, psychological, social, and somatic functioning and general wellbeing. Life satisfaction is defined as the global assessment of a person’s QOL according to his/her chosen criteria. Objective: We aimed to evaluate and correlate the QOL and life satisfaction in HNC patients who had undergone surgical treatment. Materials and Methods: A total of 60 HNC patients with a follow-up duration of 6 months to 1 year after surgery took part in our prospective study. The patients’ answers pertaining to QOL given in the questionnaire were collected for the EORTC Head and Neck questionnaire (QOL-H & N35), and then all the points were added to a value ranging between 30 and 240. The questionnaire was translated using validated methods. Clinical stage and mode of surgical treatment applied, with or without post-operative radiation therapy, were chosen to evaluate their effect on the QOL. Certain social factors were also chosen to evaluate their effect on QOL and life satisfaction. Moreover, the effects of age and gender were also studied. Results: The statistical analysis of the findings showed a strong correlation between their QOL and life satisfaction ( r = − 0.831, P = < 0.001). Spearman’s Rho formula indicates a strong relationship between QOL and life satisfaction. Conclusion: After evaluation, this study proposes that there is a strong correlation between the QOL and life satisfaction in HNC patients who were treated surgically.

10.4103/amjm.amjm_56_24

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[Cu{SC(O)OⁱPr}]₉₆: A Giant Self-Assembled Copper(I) Supramolecular Wheel Exhibiting Photoluminescence Tuning and Correlations with Dynamic Solvation and Solventless Synthesis

Inorganic Chemistry (2021)

Arvind K. Gupta Pilli V.V.N. Kishore Jhih-Yu Cyue Jian‐Hong Liao Welni Duminy

The hierarchical self-organization of structurally complex high-nuclearity metal clusters with metallosupramolecular wheel architectures that are obtained from the self-assembly of smaller solvated cluster units is rare and unique. Here, we use the potentially heteroditopic monothiocarbonate ligand and demonstrate for the first time the synthesis and structure of a solvated non-cyclic hexadecanuclear cluster [Cu{SC(O)OiPr}]16·2THF (1) that can simultaneously desolvate and self-assemble in solution and subsequently form a giant metallaring, [Cu{SC(O)OiPr}]96 (2). We also demonstrate a luminescent precursor to cluster (2) can be achieved through a solventless and rapid mechanochemical synthesis. Cluster (2) is the highest nuclearity copper(I) wheel and the largest metal cluster containing a heterodichalcogen (O, S) ligand reported to date. Cluster (2) also exhibits solid-state luminescence with relatively long emission lifetimes at 4.1, 13.9 (μs). The synthetic strategy described here opens new research avenues by replacing solvent molecules in stable {Cu16} clusters with designed building units that can form new hybrid and multifunctional finite supramolecular materials. This finding may lead to the development of novel high-nuclearity materials self-assembled in a facile manner with tunable optical properties.

10.1021/acs.inorgchem.1c00871

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Synthesis and structural characterization of xanthate ligated hydrido Cu(I) clusters and Cu(I) coordination polymer

Inorganica Chimica Acta (2019)

Pilli V.V.N. Kishore De‐Ren Shi Jian‐Hong Liao Arvind K. Gupta C. W. Liu

Xanthate

Square pyramid

10.1016/j.ica.2019.119068

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Ferrocene-Functionalized Cu(I)/Ag(I) Dithiocarbamate Clusters

Inorganic Chemistry (2016)

Pilli V.V.N. Kishore Jian‐Hong Liao Hsing-Nan Hou Yan-Ru Lin C. W. Liu

A series of compounds, namely, [Cu8(μ4-H){S2CNMeCH2Fc}6](PF6) (1), [Cu7(μ4-H) {S2CNiPrCH2Fc}6] (2), [Cu3{S2CN(Bz) (CH2Fc)}2(dppf)2](PF6) (3), and [Ag2{S2CNMe(CH2Fc)}2(PPh3)2] (4) (dppf = 1,1′-bis(diphenylphosphino)ferrocene), supported by multiferrocene assemblies, were synthesized. All the compounds were characterized by 1H NMR, Fourier transform infrared, elemental analysis, and electrospray ionization mass spectrometry techniques. Single-crystal X-ray structural analysis revealed that 1 is a monocationic octanuclear CuI cluster and that 2 is a neutral heptanuclear CuI cluster with tetracapped tetrahedral (1) and tricapped tetrahedral (2) geometries entrapped with an interstitial hydride, anchored by six ferrocene units at the periphery of the core. Compounds 3 and 4 comprise trimetallic CuI and dimetallic AgI cores enfolded by four and two ferrocene moieties. Interestingly both chelating and bridging modes of binding are observed for dppf ligand in 3. Further the formation and isolation of polyhydrido copper clusters [Cu28H15{S2CNiPrCH2Fc}12](PF6) (5) and [Cu28H15{S2CNnBu2}12](PF6) (7), stabilized by bulky ferrocenyl and n-butyl dithiocarbamate ligands, was demonstrated. They are readily identified by 2H NMR studies on their deuterium analogues, [Cu28D15{S2CNiPrCH2Fc}12](PF6) (6) and [Cu28D15{S2CNnBu2}12](PF6) (8). Though the structure details as well as spectroscopic characterizations of 5 are yet to be investigated, the compound 7 is fully characterized by variety of spectroscopy including single-crystal X-ray diffraction. The cyclic voltammetry studies for compounds 1, 2, and 4 display irreversible redox peaks for Fe2+/Fe3+ couple wherein the reduction peaks are not well-resolved due to some adsorption of the complex onto the electrode surface.

Dithiocarbamate

Proton NMR

Synthon

10.1021/acs.inorgchem.6b00201

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Citations (45)

CCDC 2019007: Experimental Crystal Structure Determination

The Cambridge Structural Database (2020)

Bharat Kumar Tripuramallu Arvapalli Revathi Yoel Friedman Pilli V.V.N. Kishore Ravada Kishore

10.5517/ccdc.csd.cc25ry85

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Pivotal role of supramolecular interactions towards the stability of Na-1,2-bis(tetrazol-5-yl) ethene coordination polymer

Journal of Molecular Structure (2020)

Bharat Kumar Tripuramallu Arvapalli Revathi Yoel Friedman Pilli V.V.N. Kishore Ravada Kishore

Coordination polymer

Coordination complex

10.1016/j.molstruc.2020.129376

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Design, synthesis and biological evaluation of novel substituted indazole-1,2,3-triazolyl-1,3,4-oxadiazoles: Antimicrobial activity evaluation and docking study

Results in Chemistry (2022)

Ananda Kumar Dunga Tejeswara Rao Allaka Yugandhar Kethavarapu Sunil Kumar Nechipadappu Pradeep Pothana

A novel series of dual 1,2,3–triazole and 1,3,4–oxadiazole heterocyclic compounds linked to indazole were designed and efficiently synthesized using 3-bromo-1H-indazole as potential antimicrobial agents. All the compounds were characterized by their proton, carbon nuclear magnetic resonance, infrared, mass spectral data, and elemental analysis. The final compounds 9a–m were evaluated in vitro antimicrobial activity against Gram–negative microorganism E. coli, Gram–positive microorganisms B. subtilis, S. pneumoniae, S. aureus and antifungal strains A. fumigates, C. albicans. From biological screening, we were surprised to find that most of the compounds have significant inhibitory activity and in particular dual heterocycles 9b, 9c, 9h, 9i, and 9j showed outstanding antibacterial activity against Gram–positive bacteria S. pneumoniae with MICs 5.4 ± 0.02, 5.8 ± 0.03, 8.0 ± 0.04, 4.0 ± 0.03, and 7.8 ± 0.01 µg/mL respectively, when compared to ampicillin [MIC = 9.1 ± 0.01 µg/mL]. Final prepared scaffolds 9b, 9h acquiring highest potential drug scores ΔG = –7.78, –8.34 Kcal/mol with their amino acids residues Arg171 (O…H: 1.934), Lys20 (N…H: 1.951), Arg265 (N…H: 2.080), ArgA:171 (2.740), ArgA:265 (1.874), TyrA:248 (1.973), and Ser19 (H…O: 2.048), Tyr248 (O…H: 1.570), Arg265 (N…H: 1.976), Arg46 (N…H: 1.059) ArgA:45 (O…H, 2.94 Å) respectively.

Indazole

Thiazole

Triazole

10.1016/j.rechem.2022.100605

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Citations (14)

Synthesis and biological activity evaluation of cytidine-5′-deoxy-5-fluoro-N-[(alkoxy/aryloxy)] carbonyl-cyclic 2′,3′-carbonates

European Journal of Medicinal Chemistry (2012)

V. Jhansi Rani Raghavendra Aminedi Pilli V.V.N. Kishore Nanda Kumar Yellapu Kamlesh Kumar

HeLa

Cytidine

MTT assay