Christopher S. Thomas

Medical University of South Carolina

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Co-Authors

W. B. R. Lickorish

New York University Press

D. G. Crighton

Total (France)

P. Wilson

Fermi National Accelerator Laboratory

J Hyland

National Oceanic and Atmospheric Administration

Thomas Ransford

Université Laval

Nicholas Lloyd

King's College London

Gabriel Segal

King's College London

Matt Barlow

University of Glasgow

Christine Kenney

Massey University

Michael Atiyah

University of Edinburgh

Cooperative Institutions

National Drug Addiction Center

168

Institute of Forensic Science

168

123 Certification (Canada)

158

Behavioral Pharma (United States)

150

Child Neurology Associates

146

New York University Press

University of Bristol

University of Cambridge

Royal Edinburgh Hospital

Virginia Commonwealth University

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Where did the patients go? Changes in acute appendicitis presentation and severity of illness during the coronavirus disease 2019 pandemic: A retrospective cohort study

Surgery (2020)

Miriam Y. Neufeld Wayne B. Bauerle Evert A. Eriksson Faris Azar Heather L. Evans

BackgroundThe coronavirus disease 2019 pandemic restricted movement of individuals and altered provision of health care, abruptly transforming health care-use behaviors. It serves as a natural experiment to explore changes in presentations for surgical diseases including acute appendicitis. The objective was to determine if the pandemic was associated with changes in incidence of acute appendicitis compared to a historical control and to determine if there were associated changes in disease severity.MethodsThe study is a retrospective, multicenter cohort study of adults (N = 956) presenting with appendicitis in nonpandemic versus pandemic time periods (December 1, 2019–March 10, 2020 versus March 11, 2020–May 16, 2020). Corresponding time periods in 2018 and 2019 composed the historical control. Primary outcome was mean biweekly counts of all appendicitis presentations, then stratified by complicated (n = 209) and uncomplicated (n = 747) disease. Trends in presentations were compared using difference-in-differences methodology. Changes in odds of presenting with complicated disease were assessed via clustered multivariable logistic regression.ResultsThere was a 29% decrease in mean biweekly appendicitis presentations from 5.4 to 3.8 (rate ratio = 0.71 [0.51, 0.98]) after the pandemic declaration, with a significant difference in differences compared with historical control (P = .003). Stratified by severity, the decrease was significant for uncomplicated appendicitis (rate ratio = 0.65 [95% confidence interval 0.47–0.91]) when compared with historical control (P = .03) but not for complicated appendicitis (rate ratio = 0.89 [95% confidence interval 0.52–1.52]); (P = .49). The odds of presenting with complicated disease did not change (adjusted odds ratio 1.36 [95% confidence interval 0.83–2.25]).ConclusionThe pandemic was associated with decreased incidence of uncomplicated appendicitis without an accompanying increase in complicated disease. Changes in individual health care–use behaviors may underlie these differences, suggesting that some cases of uncomplicated appendicitis may resolve without progression to complicated disease.

Pandemic

Presentation (obstetrics)

Coronavirus

2019-20 coronavirus outbreak

10.1016/j.surg.2020.10.035

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Citations (45)

Suicide among Psychiatric in-Patients in the Wellington Region

Australian & New Zealand Journal of Psychiatry (1993)

Deborah A. Read Christopher S. Thomas Graham Mellsop

To identify risk factors for in-patient suicide, a case-control study of in-patient suicide was conducted in the Wellington Area Health Board region between 1984 and 1989 on 27 cases and 86 controls. The risk of in-patient suicide was increased among individuals who had been compulsorily admitted, suffered from schizophrenia, had a past history of deliberate self harm, had been in hospital for more than a month, or were unmarried. Notably, there was no relationship with physical health, a history of substance abuse, number of psychiatric admissions and time since the last known episode of deliberate self harm. These characteristics can assist clinical assessment of individual suicidal risk. Further evaluation of the relation of compulsory admission to suicide is required.

Psychiatric hospital

Deliberate self-harm

10.3109/00048679309075794

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Citations (25)

BJP volume 180 issue 5 Cover and Front matter

The British Journal of Psychiatry (2002)

Vivette Glover Thomas P. O’Connor Christopher S. Thomas Tony Kendrick Nicholas Glanville

An abstract is not available for this content so a preview has been provided. As you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

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Content (measure theory)

10.1192/s0007125000160994

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Interleukin-1 Blockade in Acute Decompensated Heart Failure

Journal of Cardiovascular Pharmacology (2016)

Benjamín W. Van Tassell Nayef Abouzaki Claudia Oddi Erdle Salvatore Carbone Cory R. Trankle

Background: Heart failure is an inflammatory disease. Patients with acute decompensated heart failure (ADHF) exhibit significant inflammatory activity on admission. We hypothesized that Interleukin-1 blockade, with anakinra (Kineret, Swedish Orphan Biovitrum), would quench the acute inflammatory response in patients with ADHF. Methods: We randomized 30 patients with ADHF, reduced left ventricular ejection fraction (<40%), and elevated C reactive protein (CRP) levels (≥5 mg/L) to either anakinra 100 mg twice daily for 3 days followed by once daily for 11 days or matching placebo, in a 1:1 double blinded fashion. We measured daily CRP plasma levels using a high-sensitivity assay during hospitalization and then again at 14 days and evaluated the area-under-the-curve and interval changes (delta). Results: Treatment with anakinra was well tolerated. At 72 hours, anakinra reduced CRP by 61% versus baseline, compared with a 6% reduction among patients receiving placebo (P = 0.004 anakinra vs. placebo). Conclusions: Interleukin-1 blockade with anakinra reduces the systemic inflammatory response in patients with ADHF. Further studies are warranted to determine whether this anti-inflammatory effect translates into improved clinical outcomes.

10.1097/fjc.0000000000000378

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Citations (117)

HIV and Informed Consent

The British Journal of Psychiatry (1987)

Christopher S. Thomas

An abstract is not available for this content so a preview has been provided. As you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

Content (measure theory)

10.1192/bjp.151.3.410b

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Citations (2)

[No Title]

The British Journal of Psychiatry (1988)

Christopher S. Thomas E. Szabadi

An abstract is not available for this content so a preview has been provided. As you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

Content (measure theory)

10.1192/s0007125000219041

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Contributors

Elsevier eBooks (2022)

Andrew Y. Abashkin Samar Abdelhady Reem Abedi Darya I. Agarkova Hasan B. Alam

10.1016/b978-0-12-823347-4.09992-9

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Psychological consequences of traumatic injury

The British Journal of Psychiatry (2002)

Christopher S. Thomas

Whiplash injuries commonly occur in road traffic accidents, although early descriptions of railway spine following rail accidents would appear to be similar (Trimble, 1981). Initial acute symptoms include neck pain, restricted mobility in the cervical spine, headache, pain in the thoracic spine, radiating pain, paraesthesiae and/or weakness in the arms or legs (Spitzer et al , 1995). These somatic symptoms often are accompanied by psychological symptoms such as initial ‘shock’, a ‘dazed’ feeling, anxiety, anger, depression, difficulty concentrating, insomnia, lassitude, loss of libido, altered appetite and weight and, in some cases, feelings of helplessness, horror, despair and reliving experiences (Mayou & Radanov, 1996).

Depression

Learned helplessness

Photophobia

10.1192/bjp.180.5.392

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Citations (7)

Severity of Withdrawal in Subjects Exposed to a Combination of Alcohol and Minor Tranquillisers

The British Journal of Psychiatry (1989)

Christopher S. Thomas Mark Spurrell Richard D. Hackett B. D. Hore

Fifty patients suffering from the alcohol dependence syndrome were detoxified over a 10-day period using a reducing regime of chlordiazepoxide. Twenty-four had been consuming minor tranquillisers together with alcohol prior to admission. The severity of the withdrawal syndrome was assessed daily but no differences were found between the 26 who had taken alcohol alone and the 24 who had taken a combination of alcohol and drugs. Four from each group had a transient hallucinosis and none had fits.

Alcohol withdrawal syndrome

Chlordiazepoxide

10.1192/bjp.154.1.83

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Citations (3)

BJZ volume 83 issue 342 Cover and Front matter

Journal of Mental Science (1937)

Douglas Mcrae Lionel Dabbadie Stephen D. Penrose Mary London Abdy Â€"michael

An abstract is not available for this content so a preview has been provided. As you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

Front cover

Content (measure theory)

10.1192/s0368315x00037191

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Citations (0)