Loredana G. Marcu

University of South Australia

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Eva Bezak

University of South Australia

Barry Allen

Western Sydney University

Alexandru Daşu

Uppsala University

David Marcu

Information Technology University

Ian Olver

University of Adelaide

Iuliana Toma-Daşu

Stockholm University

Claes Mercke

Karolinska University Hospital

Leyla Moghaddasi

Royal North Shore Hospital

Paul Reid

University of South Australia

Efi Koutsouveli

Hygeia Hospital

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Royal Adelaide Hospital

University of Adelaide

University of South Australia

Inserm

University of Oradea

Institut de Cancérologie de l'Ouest

Institut Génétique Nantes Atlantique

Centre National de la Recherche Scientifique

Centre de Recherche en Cancérologie et Immunologie Intégrée Nantes Angers

Leiden University Medical Center

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Scheduling cisplatin and radiotherapy in the treatment of squamous cell carcinomas of the head and neck: a modelling approach

Physics in Medicine and Biology (2006)

Loredana G. Marcu Eva Bezak Ian Olver

The aim of the present work was to implement the kinetics of cisplatin into a previously developed tumour growth model and to simulate the combined cisplatin-radiotherapy treatment with the emphasis on time sequencing and scheduling of drug and radiation. An investigation into whether the effect of cisplatin-radiation is determined by independent cell kill or by cisplatin-produced radiosensitization was also undertaken. It was shown that cisplatin administered before radiation conferred similar tumour control to the post-radiation sequencing of the drug. The killing effect of the combined modality treatment on tumour increased with the increase in cell recruitment. Furthermore, the individual cell kill produced by the two cytotoxins led to an additive only tumour response when the treatments were given concurrently, suggesting that for a synergistic effect, cisplatin must potentiate the effect of radiation, through the radiosensitizing mechanisms addressed in the literature. It was concluded that the optimal timing of cisplatin should be close to radiation. The model showed that daily administration of cisplatin led to a 35% improvement of tumour control as compared to radiation alone, while weekly cisplatin has improved radiotherapy by only 6%.

10.1088/0031-9155/51/15/002

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Citations (30)

Points of view on artificial intelligence in medical imaging—one good, one bad, one fuzzy

Health and Technology (2021)

Loredana G. Marcu David Marcu

10.1007/s12553-020-00515-5

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Citations (12)

EFOMP policy statement 18: Medical physics education for the non-physics healthcare professions

Physica Medica (2023)

Carmel J. Caruana Richard A. Amos Diego F. B. Sarzosa S. Heukelom Marija Jeremić