José Carlos Cogo

Universidade Brasil

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Yoko Oshima‐Franco

Universidade de Sorocaba

Stephen Hyslop

Universidade Estadual de Campinas (UNICAMP)

Stella Regina Zamunér

Universidade Nove de Julho

Léa Rodrigues‐Simioni

Universidade Estadual de Campinas (UNICAMP)

Edson Hideaki Yoshida

Universidade de Sorocaba

J. Prado-Franceschi

Universidade Estadual de Campinas (UNICAMP)

Ana Maria Barbosa

Universidade do Vale do Paraíba

Maria Alice da Cruz‐Höfling

Universidade Estadual de Campinas (UNICAMP)

Márcio Galdino dos Santos

Universidade Federal do Tocantins

Gilberto De Nucci

Universidade Estadual de Campinas (UNICAMP)

Cooperative Institutions

Universidade Estadual de Campinas (UNICAMP)

Universidade de São Paulo

Universidade de Sorocaba

Universidade do Vale do Paraíba

Universidade Brasil

Universidade Nove de Julho

Universidade Federal de São Paulo

Universidade Estadual Paulista (Unesp)

Instituto Butantan

Universidade Federal de São Carlos

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New pharmacological insights of Galactia glaucescens

Natural Product Research (2018)

Márcio Galdino dos Santos Felipe Silveira Moreno Akila L. Oliveira Isadora Caruso Fontana Oliveira Natália Tribuiani

Galactia glaucescens leaves are popularly used against snakebites in Brazil. The hydroethanolic extract from aerial parts of G. glaucescens (HEGg) was assayed against the neurotoxicity and myotoxicity induced by Bothrops jararacussu venom. A traditional myographic technique was applied for neurotoxicity and the resulting muscles were treated routinely by light microscopy analysis for myotoxicity. Additionally, the antimicrobial potential of HEGg was evaluated against Staphylococcus aureus, Escherichia coli and Pseudomonas aeruginosa strains, as well as Rutin was isolated for the first time in this specie using chromatographic and spectroscopic methods and its antiophidian property was assessed. HEGg totally prevents the neurotoxicity and myotoxicity effects caused by B. jararacussu, but did not show any antimicrobial effect. Concluding, HEGg and Rutin were able to counteract the toxic effects of the venom and confirmed the antiophidian potential, but not antimicrobial, of G. glaucescens as an alternative for neutralization of B. jararacussu venom.

Bothrops

Neurotoxicity

Myotoxin

10.1080/14786419.2018.1443086

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Citations (1)

The Evolutionary Implications of Hemipenial Morphology of Rattlesnake Crotalus durissus terrificus (Laurent, 1768) (Serpentes: Viperidae: Crotalinae)

PLoS ONE (2013)

Marcovan Porto Marco Antônio de Oliveira Lorenzo Pissinatti Renata Lopes Rodrigues Julio Alejandro Rojas-Moscoso

Most amniotes vertebrates have an intromittent organ to deliver semen. The reptile Sphenodon and most birds lost the ancestral penis and developed a cloaca-cloaca mating. Known as hemipenises, the copulatory organ of Squamata shows unique features between the amniotes intromittent organ. They are the only paired intromittent organs across amniotes and are fully inverted and encapsulated in the tail when not in use. The histology and ultrastructure of the hemipenes of Crotalus durissus rattlesnake is described as the evolutionary implications of the main features discussed. The organization of hemipenis of Crotalus durissus terrificus in two concentric corpora cavernosa is similar to other Squamata but differ markedly from the organization of the penis found in crocodilians, testudinata, birds and mammals. Based on the available data, the penis of the ancestral amniotes was made of connective tissue and the incorporation of smooth muscle in the framework of the sinusoids occurred independently in mammals and Crotalus durissus. The propulsor action of the muscle retractor penis basalis was confirmed and therefore the named should be changed to musculus hemipenis propulsor.The retractor penis magnus found in Squamata has no homology to the retractor penis of mammals, although both are responsible for the retraction of the copulatory organ.

Viperidae

Cloaca

Crotalus

10.1371/journal.pone.0066903

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Citations (23)

Prospective study of a Bothrops jararacussu venom batch (Bj2015) – phospholipase A₂ activity, immunogenicity, neurotoxicity, and myotoxicity parameters

Natural Product Research (2018)

Isadora Caruso Fontana Oliveira Adriana Dalla Mora Jairo Braga Neto Akila L. Oliveira Carolina Harder

Bothrops jararacussu venom’s (Bj2015) batch was biomonitored quarterly for one year to assess phospholipase A2 (PLA2) activity, immunogenicity, neurotoxicity, and myotoxicity. In silico models were applied to evaluate losses using decay model and recoveries by predictive trend analysis. Mice were immunized with Bj2015. Antibodies were detected by double-immunodiffusion and total protein and albumin were measured. Neuromuscular blockade-induced by 40 μg mL−1 venom solution was carried out using mouse nerve phrenic-diaphragm preparation. Resulting muscles were submitted to light microscopy to evaluate the myotoxicity. PLA2 activity of 0.1 mg mL−1 Bj2015 was measured using 4-nitro-3-(octanoyloxy)benzoic acid as substrate. Over time, greater losses occurred in neurotoxicity than PLA2, but not in myotoxicity and immunogenicity. Concluding, the neurotoxicity decrease can be related to enzymatic losses, including PLA2. Depending on the purpose of use, the collected venom responds on a long time, avoiding unnecessary new collections, improving life quality of animals in captivity and increasing their longevity.

Myotoxin

Bothrops

Neurotoxicity

10.1080/14786419.2018.1446010

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Citations (1)

An unusual presynaptic action of Bothrops insularis snake venom mediated by phospholipase A2 fraction

Toxicon (1998)

José Carlos Cogo J. Prado-Franceschi J.R. Giglio A.P. Corrado Maria Alice da Cruz‐Höfling

Sephadex

Bothrops

Neuromuscular transmission

Neurotoxin

10.1016/s0041-0101(97)00174-8

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Citations (33)

Effects of high-dose creatine supplementation on kidney and liver responses in sedentary and exercised rats.

PubMed (2009)

Renato Aparecido de Souza Humberto Miranda Murilo Xavier Rodrigo Alexis Lazo-Osório Hélio Andrade Gouvêa

This study evaluated the effects of high-dose of short-term creatine supplementation (5g.kg(-1).day(-1) to 1 week) and long-term creatine supplementation (1g.kg(-1). day(-1) to 4-8 weeks) on kidney and liver structure and function of sedentary and exercised Wistar rats (Exercise sessions consisted of swimming at 80% of maximal work load supported during 5 days per week with daily sessions of 60 minutes throughout the duration of the supplementation). Seventy- two animals (245 ± 5g) were divided into four groups (n = 18): control diet Sedentary (SED), Creatine diet Sedentary (CRE), control diet Exercised (EXE), and Creatine diet Exercised (EXECRE). Histological and blood biochemical studies were performed after one, four, and eight weeks of creatine supplementation and exercise (n = 6). No differences were found when comparing SED, EXE and EXECRE groups for kidney and liver structure and function at one, four and eight weeks. However, the CRE group showed higher levels of creatinine (1.1 ± 0.2 vs. 0.4 ± 0.1 mg.dl(-1); p < 0.05), and urea (37 ± 3 vs. 19 ± 1 mg.dl(-1); p < 0.05) when compared with all others groups at four and eight weeks. At eight weeks, the CRE group presented increased levels of ALT (41 ± 7 vs. 23 ± 7 U.L(-1); p < 0.05), AST (89 ± 6 vs. 62 ± 5 U.L(-1); p < 0.05), GGT (8.0 ± 0.9 vs. 3.9 ± 1.0 U.L(-1); p < 0.05), and AP (125 ± 10 vs. 69 ± 9 U.L(-1); p < 0.05) also when compared with all others groups. Moreover, the CRE group demonstrated some structural alterations indicating renal and hepatic damage at four and eight weeks, respectively. These results suggest that long-term creatine supplementation (up to 4-8 weeks) may adversely affect kidney and liver structure and function of sedentary but not of exercised rats. Key pointsCreatine supplementation is an established ergogenic aid in sports and is now claimed to have therapeutical applications in a variety of diseases.Although acknowledged, this nutritional supplement is rarely monitored precisely about their possible side effects.Previous studies indicated that short-term creatine supplementation associate with the physical exercise may be safe, but the effect of long-term creatine supplementation is still unknown.There is a need for further research to elucidate the controversial points refers to renal and hepatic function after creatine supplementation.The results of the current study indicate that supraphysiological long-term creatine supplementation (up to 4-8 weeks) may adversely affect kidney and liver structure and function of sedentary but not of exercised rats.

Creatine

Creatine Monohydrate

sed

Creatine kinase

Source

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Citations (18)

Ability of tannic acid administered intraperitoneally against the lethality of Bothrops jararaca venom

Toxicon (2020)

Isadora Caruso Fontana Oliveira Edson Hideaki Yoshida Marcos Antônio de Queiroz José Carlos Cogo Denise Grotto

Bothrops jararaca

Tannic acid

Lethality

Bothrops

10.1016/j.toxicon.2019.12.068

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Citations (0)

TLR4 signaling protects from excessive muscular damage induced by Bothrops jararacussu snake venom

Toxicon (2012)

Eustáquio Luiz Paiva-Oliveira Rafael Ferreira da Silva Paulo Emílio Côrrea Leite José Carlos Cogo Thereza Quírico‐Santos

Immune cells and skeletal muscle express Toll-like receptors (TLRs) that participate as sensors of tissue injury triggering signals for activation of innate and adaptive immune responses. This study aimed to investigate the involvement of TLR4 in the process of skeletal muscle repair. Muscular injury was induced by injection of 0.6 mg/kg of Bothrops jararacussu snake venom in the gastrocnemius muscle of C3H/HeJ mice that express a non-functional TLR-4 receptor and C3H/HeN mice with functional receptor. TLR4-deficient mice had persistent muscular inflammation with few F4/80 macrophages at onset but increased MMP9 activity and collagen deposition during resolution of injury. Since such effect was not observed in the mouse strain with functional receptor it is concluded that TLR4 signaling exerts a protective role preventing from excessive muscular damage induced by B. jararacussu venom.

Bothrops

10.1016/j.toxicon.2012.10.003

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Citations (15)

fMRI of the sensorimotor cortex in patients with traumatic brain injury after intensive rehabilitation

Neurological Sciences (2011)

Fernanda Púpio Silva Lima Mário Oliveira Lima Daniel León Paulo Roberto Garcia Lucareli Carles Falcón

Supplementary motor area

Neuroradiology

10.1007/s10072-011-0604-6

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Citations (12)