Irina Kalashnikova

Kurchatov Institute

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i-10 index

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Co-Authors

Jonghyuck Park

University of Kentucky

Erik Rytting

The University of Texas Medical Branch at Galveston

Bernard Cathala

Biopolymères Interactions Assemblages

ЛМ

Л. М. Горностаев

Krasnoyarsk State Pedagogical University

Tatiana Tennikova

St Petersburg University

Meghan Hill

Michigan State University

Hervé Bizot

Biopolymères Interactions Assemblages

N. D. Ivanova

Institute of Biomedical Chemistry

Daniel Kolpek

University of Kentucky

Taeho Kim

Michigan State University

Cooperative Institutions

Russian Academy of Sciences

The University of Texas Medical Branch at Galveston

Stanford University

University of Miami

University of Michigan–Ann Arbor

Michigan State University

Lomonosov Moscow State University

Neurological Surgery

Stanford Medicine

The University of Texas Health Science Center at Houston

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Papers

Citation

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Preparation, characterization, and transport of dexamethasone-loaded polymeric nanoparticles across a human placental in vitro model

International Journal of Pharmaceutics (2013)

Hazem Ali Irina Kalashnikova Mark A. White Michael B. Sherman Erik Rytting

Zeta potential

Dispersity

PLGA

10.1016/j.ijpharm.2013.07.010

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Citations (97)

Encapsulation of Oil Phases with Different Compositions into a Shell Composed of Nanoparticles of Natural Hydrothermal Silica and Polyelectrolyte Layers

Colloid Journal (2021)

К. В. Паламарчук Т. В. Букреева Irina Kalashnikova Valery N. Zelenkov В. В. Потапов

Nanocapsules

Dodecane

Cationic polymerization

Zeta potential

Pickering emulsion

10.1134/s1061933x21020083

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Citations (8)

Адаптация белых берез (Betula pendula Roth и B. pubescens Ehrh.) к условиям нарушенных земель (золоотвалов)

Аграрная Россия (2009)

Irina Kalashnikova

Betula pendula

Betula pubescens

10.30906/1999-5636-2009-0-90-91

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Citations (0)

Synthesis of 1-aryl-6-nitro-1H-benzotriazoles by intramolecular cyclization of 1-aryl-3-(2-fluoro-4-nitrophenyl)- and 1-aryl-3-(2,4-dinitrophenyl)triazenes

Chemistry of Heterocyclic Compounds (2018)

Л. М. Горностаев Irina Kalashnikova

Dinitrophenyl

Nitro compound

10.1007/s10593-018-2356-1

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Citations (1)

Correction: Optimization and characterization of miRNA-129-5p-encapsulated poly (lactic-co-glycolic acid) nanoparticles to reprogram activated microglia

Nanoscale Advances (2023)

Irina Kalashnikova Heather R. Campbell Daniel Kolpek Jonghyuck Park

Correction for ‘Optimization and characterization of miRNA-129-5p-encapsulated poly (lactic- co -glycolic acid) nanoparticles to reprogram activated microglia’ by Irina Kalashnikova, et al. , Nanoscale Adv. , 2023, https://doi.org/10.1039/D3NA00149K.

Glycolic acid

Characterization

10.1039/d3na90065g

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Citations (0)

ChemInform Abstract: Synthesis of 1‐Aryl‐5‐nitrobenzotriazoles

ChemInform (2014)

Л. М. Горностаев Н. А. Булгакова Irina Kalashnikova

Abstract via cyclization reaction of readily available triazenes (III)

10.1002/chin.201421149

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Citations (0)

Adsorption of cationic polymers on the surfaces of anionic glass microspheres

Polymer Science Series A (2012)

A. S. Malinin Irina Kalashnikova A. A. Rakhnyanskaya A. A. Yaroslavov

Cationic polymerization

Polymer Adsorption

10.1134/s0965545x1201004x

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Citations (7)

Nanoparticles decorated with granulocyte-colony stimulating factor for targeting myeloid cells

Nanoscale (2020)

Katherine Margulis Alexander Honkala Irina Kalashnikova Sarah E. Noll Meghan Hill

Dysregulated myeloid cell activity underlies a variety of pathologies, including immunosuppression in malignant cancers. Current treatments to alter myeloid cell behavior also alter other immune cell subpopulations and nonimmune cell types with deleterious side effects. Therefore, improved selectivity of myeloid treatment is an urgent need. To meet this need, we demonstrate a novel, targeted nanoparticle system that achieves superior myeloid selectivity both in vitro and in vivo. This system comprises: (1) granulocyte-colony stimulating factor (G-CSF) as a targeting ligand to promote accumulation in myeloid cells, including immunosuppressive myeloid-derived suppressor cells (MDSCs); (2) albumin nanoparticles 100-120 nm in diameter that maintain morphology and drug payload in simulated physiological conditions; and (3) a fluorophore that enables nanoparticle tracking and models a therapeutic molecule. Here, we show that this strategy achieves high myeloid uptake in mixed primary immune cells and that nanoparticles successfully infiltrate the 4T1 triple-negative breast tumor murine microenvironment, where they preferentially accumulate in myeloid cells in a mouse model. Further development will realize diagnostic myeloid cell tracking applications and therapeutic delivery of myeloid-reprogramming drugs.

Myelopoiesis

Myeloid-derived Suppressor Cell

10.1039/c9nr06494j

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Citations (6)

Extracellular vesicle coated prussian blue nanoparticles for effective cancer phototheranostics

Meghan Hill Irina Kalashnikova Md Nafiujjaman Victoria Toomajian Taeho Kim

Prussian blue

Extracellular Vesicles

10.1021/scimeetings.0c07038

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Citations (0)

Biodegradable nanoparticles targeting circulating immune cells reduce central and peripheral sensitization to alleviate neuropathic pain following spinal cord injury

Pain (2023)

Michael N. Saunders Kate Griffin Irina Kalashnikova Daniel Kolpek Dominique R. Smith

Abstract Neuropathic pain is a critical source of comorbidity following spinal cord injury (SCI) that can be exacerbated by immune-mediated pathologies in the central and peripheral nervous systems. In this article, we investigate whether drug-free, biodegradable, poly(lactide- co -glycolide) (PLG) nanoparticle treatment mitigates the development of post-SCI neuropathic pain in female mice. Our results show that acute treatment with PLG nanoparticles following thoracic SCI significantly reduces tactile and cold hypersensitivity scores in a durable fashion. Nanoparticles primarily reduce peripheral immune-mediated mechanisms of neuropathic pain, including neuropathic pain-associated gene transcript frequency, transient receptor potential ankyrin 1 nociceptor expression, and MCP-1 (CCL2) chemokine production in the subacute period after injury. Altered central neuropathic pain mechanisms during this period are limited to reduced innate immune cell cytokine expression. However, in the chronic phase of SCI, nanoparticle treatment induces changes in both central and peripheral neuropathic pain signaling, driving reductions in cytokine production and other immune-relevant markers. This research suggests that drug-free PLG nanoparticles reprogram peripheral proalgesic pathways subacutely after SCI to reduce neuropathic pain outcomes and improve chronic central pain signaling.

Nociceptor

Nerve Injury

10.1097/j.pain.0000000000002989

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Citations (3)