Ibrahim Al‐Jammaz

King Faisal Specialist Hospital & Research Centre

Author Statistics

Papers

Citation

H-Index

i-10 index

Research Trends

Author Order

Document Type

Co-Authors

Subhani M. Okarvi

King Faisal Specialist Hospital & Research Centre

Yousif H. Al-Malki

King Faisal Specialist Hospital & Research Centre

Basem Al‐Otaibi

King Faisal Specialist Hospital & Research Centre

Falah Almohanna

King Faisal Specialist Hospital & Research Centre

J.K. Amartey

King Faisal Specialist Hospital & Research Centre

B. Al-Otaibi

Imam Abdulrahman Bin Faisal University

Brian F. Meyer

Inserm

Futwan Al‐Mohanna

King Faisal Specialist Hospital & Research Centre

Yufei Shi

University of Science and Technology of China

Minjing Zou

King Faisal Specialist Hospital & Research Centre

Cooperative Institutions

King Faisal Specialist Hospital & Research Centre

Baylor College of Medicine

National Institutes of Health

King Saud University

University of Michigan–Ann Arbor

Alfaisal University

Cyclotron (Netherlands)

King Abdulaziz City for Science and Technology

Horizon Therapeutics (United States)

National Institute of Diabetes and Digestive and Kidney Diseases

Author Statistics

Papers

Citation

H-Index

i-10 index

Research Field

Novel synthesis of 2-[18F]-fluoroisonicotinic acid hydrazide and initial biological evaluation

Nuclear Medicine and Biology (2002)

J.K. Amartey Ibrahim Al‐Jammaz B. Al-Otaibi C. Esguerra

Hydrazine (antidepressant)

Biodistribution

10.1016/s0969-8051(02)00340-2

Cite

Citations (16)

Synthesis and in vitro and in vivo evaluation of iodine-124-labelled PSMA peptides: Potential theranostic radiopharmaceuticals for prostate cancer

Ibrahim Al‐Jammaz Abdulrahman Alrabiah Basim Alotaibi F. Alrumayan Subhani M. Okarvi

Glutamate carboxypeptidase II

Source

Cite

Citations (0)

Development of new copper-64 labeled rhodamine: a potential PET myocardial perfusion imaging agent

EJNMMI Radiopharmacy and Chemistry (2022)

Norah Alhokbany Ibrahim Al‐Jammaz Basem Al‐Otaibi Yousif H. Al-Malki Bander AlJammaz

Abstract Background Myocardial perfusion imaging (MPI) is one of the most commonly performed investigations in nuclear medicine procedures. Due to the longer half-life of the emerging positron emitter copper-64 and its availability from low energy cyclotron, together with its well-known coordination chemistry, we have synthesized 64 Cu-labeled NOTA- and 64 Cu-NOTAM-rhodamine conjugates as potential cardiac imaging agents using PET. Results 64 Cu-NOTA- and 64 Cu-NOTAM-rhodamine conjugates were synthesized using a traightforward and one-step simple reaction. Radiochemical yields were greater than 97% (decay corrected), with a total synthesis time of less than 25 min. Radiochemical purities were always greater than 98% as assessed by TLC and HPLC. These synthetic approaches hold considerable promise as a simple method for 64 Cu-rhodamine conjugates synthesis, with high radiochemical yield and purity. Biodistribution studies in normal Fischer rats at 60 min post-injection, demonstrated significant heart uptake and a good biodistribution profile for both the radioconjugates. However, the 64 Cu-NOTAM-rhodamine conjugate has shown more heart uptake (~ 10% ID/g) over the 64 Cu-NOTA-rhodamine conjugate (5.6% ID/g). Conclusions These results demonstrate that these radioconjugates may be useful probes for the PET evaluation of MPI.

Biodistribution

Conjugate

Rhodamine

Rhodamine B

PET Imaging

Rhodamine 123

10.1186/s41181-022-00171-2

Cite

Citations (2)

2-[18F]-fluoroisonicotinic acid hydrazide: biological evaluation in an acute infection model

Applied Radiation and Isotopes (2004)

J.K. Amartey C. Esguerra B. Al-Otaibi Ranjit S. Parhar Ibrahim Al‐Jammaz

Biodistribution

Hydrazine (antidepressant)

10.1016/j.apradiso.2004.01.009

Cite

Citations (6)

Synthesis of novel 18F[FDG] labeled rhodamine: A potential PET myocardial perfusion imaging agent

Journal of Nuclear Medicine (2015)

Ibrahim Al‐Jammaz Subhani M. Okarvi Basim Alotaibi

1047 Objectives Myocardial perfusion imaging (MPI) is usually performed using single-photon radiopharmaceuticals like 99mTc-MIBI, 99mTc-tetrofosmin and 201Tl-chloride. Unlike SPECT, PET imaging offers several advantages in MPI. The currently used PET tracers for MPI studies (13NH3, 82Rb and 15O-water) have limitations. Rhodamine dyes are known to accumulate in the heart; thus several 18F-labeled rhodamine B were reported recently as potential MPI agents. Due to the clinical importance of [18F]-FDG and its availability we here report the synthesis and preclinical evaluation of new [18F]-FDG-rhodamine Methods [18F]-FDG (300 MBq) was reacted with oxime-rhodamine conjugate in 1%HoAc/EtOH at 60oC for 10 min. Work up of this reaction gave [18F]-FDG-rhodamine conjugate in quantitative radiochemical yield and purity as assessed by TLC/HPLC in less than 20 min. [18F]-FDG-rhodamine conjugate was incubated with human plasma in duplicate at 37oC for 2 h and supernatant layers were analyzed by HPLC. Rats were injected via the lateral tail vein with the radiotracer. Animals were sacrificed after 60 min and tissues of interest were dissected, weighed and assayed for radioactivity Results The synthetic approaches hold considerable promise as rapid and simple method for radiolabeling of rhodamine with [18F]-FDG in high radiochemical yield and in short time. The stability studies of [18F]-FDG-rhodamine plasma revealed that this radioconjugate remained stable. In vivo biological studies in rats at 60 min p.i., demonstrated fast and efficient clearance of [18F]-FDG-rhodamine from the blood and most of the organs and tissues. The target organ heart showed highest uptake (11.24±1.97%) of the %ID/g. This result demonstrates that [18F]-FDG-rhodamine may be useful PET for MPI. Conclusions [18F]-FDG-rhodamine was prepared in quantitative radiochemical yields and purities in less than 20 min. Biodistribution in rats showed high myocardial uptake and favorable pharmacokinetics. These results demonstrate that this radioconjugate may be useful for MPI studies using PET.

Rhodamine

Conjugate

Rhodamine 123

Rhodamine B

Source

Cite

Citations (0)

An efficient batch preparation of high specific activity [123I] and [124I] mIBG

Applied Radiation and Isotopes (2001)

J.K. Amartey Ibrahim Al‐Jammaz Richard M. Lambrecht

Ammonium sulfate

Specific activity

10.1016/s0969-8043(00)00340-7

Cite

Citations (11)

Synthesis, characterization and density functional theory of 64Cu based complex for hypoxia imaging

Journal of King Saud University - Science (2024)

Norah Alhokbany Ibrahim Al‐Jammaz B.M. Alotaibi Yousif H. Al-Malki S. Almasaari

Characterization

Hypoxia

10.1016/j.jksus.2024.103398

Cite

Citations (0)

Synthesis, radiolabelling and biological characteristics of a bombesin peptide analog as a tumor imaging agent.

PubMed (2003)

Subhani M. Okarvi Ibrahim Al‐Jammaz

Several human cancers, including small cell lung, prostate, breast, gastric, colon and pancreatic cancers, express receptors for bombesin-like peptides. Bombesin (BN) peptides that bind specifically to these receptors are useful for detection of bombesin receptor-expressing cancers in vivo. A new 99mTc-labelled-BN peptide for targeting bombesin receptor-expressing cancers was prepared and characterized.MAG3-coupled BN peptide (MAG3-BN) was prepared by solid-phase synthesis and radiolabelled with 99mTc by an exchange method. In vitro cell binding assays were conducted on human breast cancer cell lines, MDA-MB-231 and MCF-7. In vivo biodistribution studies were performed in normal and nude mice bearing bombesin receptor-positive tumors.Radiolabelling of MAG3-BN with 99mTc produces a single radioactive species (> 95%). In vitro cell-binding indicated the affinity and specificity of 99mTc-MAG3-BN towards bombesin receptors. In vivo biodistribution in mice demonstrated that 99mTc-MAG3-BN cleared rapidly from the blood and most non-targeted tissues and was excreted mainly via the kidneys. Uptake in bombesin receptor-positive tissues and in the tumor was low to moderate.99mTc-MAG3-BN displays good radiolabelling together with certain favorable biological characteristics and might be a useful peptide radiopharmaceutical in the detection of bombesin receptor-expressing cancers in vivo.

Biodistribution

Source

Cite

Citations (23)

The curcumin analogue PAC has potent anti-anaplastic thyroid cancer effects

Research Square (Research Square) (2022)

Mai Almohanna Samiah Alhabardi Noura N. Alraouji Falah Almohanna Baseem Al-Otaibi

Abstract Anaplastic thyroid carcinoma (ATC) is the rarest type of thyroid cancer but is the common cause of death from these tumors. The aggressive behavior of ATC makes it resistant to the conventional therapeutic approaches. Thus, the present study was designed to evaluate the anti-ATC efficacy of the curcumin analogue PAC. We have shown that PAC induces apoptosis in thyroid cancer cells in a time-dependent fashion through the mitochondrial pathway. Immunoblotting analysis revealed that PAC suppressed the epithelial-to-mesenchymal transition (EMT) process in ATC cells by increasing the epithelial marker E-cadherin and reducing the level of the mesenchymal markers N-cadherin, Snail, Slug and Twist1. This anti-EMT effect was confirmed by showing PAC-dependent inhibition of the proliferation and migration abilities of ATC cells. In addition, PAC downregulated ALDH1 and suppressed the formation of thyroid tumorespheres in vitro . Interestingly, PAC inhibited the AKT/mTOR pathway in ATC cells. Indeed, PAC downregulated mTOR and its downstream effectors p70S6K and 4E-BP1 more efficiently than the well-known mTOR inhibitor rapamycin. In addition to the promising in vitro anticancer efficacy, PAC significantly suppressed the growth of humanized thyroid tumor xenografts in mice. Together, these findings indicate that PAC could be considered as promising therapeutic agent for anaplastic thyroid carcinomas.

Anaplastic thyroid cancer

10.21203/rs.3.rs-2160938/v1

Cite

Citations (0)

A novel route to radioiodinated [123I]-N-succinimidyl-3-iodobenzoate, a reagent for radioiodination of bioactive peptides

Applied Radiation and Isotopes (2002)

Ibrahim Al‐Jammaz B. Al-Otaibi J.K. Amartey

Moiety

Biodistribution

10.1016/s0969-8043(02)00191-4

Cite

Citations (8)