Philippe Jay

Institut de Génomique Fonctionnelle

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François Gerbe

Institut de Génomique Fonctionnelle

Philippe Blache

Inserm

Dominique Joubert

University Hospital of Geneva

Frédéric Hollande

University of Melbourne

Pauline Bastide

Centre National de la Recherche Scientifique

Julie Pannequin

Institut de Génomique Fonctionnelle

Hassan Zalzali

American University of Beirut

Pierre Cesses

Inserm

Alicia Giordano

Institut de Génomique Fonctionnelle

Marco Bruschi

Institut Gustave Roussy

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Inserm

185

Centre National de la Recherche Scientifique

184

Université de Montpellier

132

Institut de Génomique Fonctionnelle

Institut de Génétique Moléculaire de Montpellier

Centre de Recherche en Biologie cellulaire de Montpellier

Institut de Recherche en Cancérologie de Montpellier

Université Paris Cité

Institut de Génétique Humaine

La Ligue Contre le Cancer

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The intestinal epithelium tuft cells: specification and function

Cellular and Molecular Life Sciences (2012)

François Gerbe Catherine Legraverend Philippe Jay

The intestinal epithelium, composed of at least seven differentiated cell types, represents an extraordinary model to understand the details of multi-lineage differentiation, a question that is highly relevant in developmental biology as well as for clinical applications. This review focuses on intestinal epithelial tuft cells that have been acknowledged as a separate entity for more than 60 years but whose function remains a mystery. We discuss what is currently known about the molecular basis of tuft cell fate and differentiation and why elucidating tuft cell function has been so difficult. Finally, we summarize the current hypotheses on their potential involvement in diseases of the gastro-intestinal tract.

Tuft

Intestinal epithelium

Lineage (genetic)

Cell lineage

10.1007/s00018-012-0984-7

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Citations (241)

Table S1 : RNA-seq data from Lgr5-GFP+ cells from Loss of Apc Rapidly Impairs DNA Methylation Programs and Cell Fate Decisions in Lgr5+ Intestinal Stem Cells

Marco Bruschi Laure Garnier Elouan Cleroux Alicia Giordano Michael Dumas

This file contains all RNAseq results for gene expression comparisons between FACS sorted ApcWT-, ApcHET-, and ApcKO-Lgr5-GFP profiles.

LGR5

10.1158/0008-5472.22423848.v1

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Citations (0)

Table S3 : GSEA on KEGG collection results from Loss of Apc Rapidly Impairs DNA Methylation Programs and Cell Fate Decisions in Lgr5+ Intestinal Stem Cells

Marco Bruschi Laure Garnier Elouan Cleroux Alicia Giordano Michael Dumas

This file contains GSEA results from ApcWT- and ApcKO-Lgr5 cells for collections of signatures related to KEGG functional pathways.

LGR5

Table (database)

KEGG

10.1158/0008-5472.22423842.v1

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Supplementary Figure 2 from Defective Claudin-7 Regulation by Tcf-4 and Sox-9 Disrupts the Polarity and Increases the Tumorigenicity of Colorectal Cancer Cells

Charbel Darido Michael Büchert Julie Pannequin Pauline Bastide Hassan Zalzali

Supplementary Figure 2 from Defective Claudin-7 Regulation by Tcf-4 and Sox-9 Disrupts the Polarity and Increases the Tumorigenicity of Colorectal Cancer Cells

Polarity (international relations)

Claudin

10.1158/0008-5472.22375250

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Supplementary Figure 3 from Defective Claudin-7 Regulation by Tcf-4 and Sox-9 Disrupts the Polarity and Increases the Tumorigenicity of Colorectal Cancer Cells

Charbel Darido Michael Büchert Julie Pannequin Pauline Bastide Hassan Zalzali

Supplementary Figure 3 from Defective Claudin-7 Regulation by Tcf-4 and Sox-9 Disrupts the Polarity and Increases the Tumorigenicity of Colorectal Cancer Cells

Polarity (international relations)

Claudin

10.1158/0008-5472.22375247

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Tuft cell-derived acetylcholine is an effector of type 2 immunity and directly targets helminth parasites in the gut lumen

bioRxiv (Cold Spring Harbor Laboratory) (2023)

Marième Ndjim Fabien Herbert Imène Gasmi Charlène Joséphine Sylvain Henri

SUMMARY Upon parasitic helminth infection, activated intestinal tuft cells secrete IL-25, which initiates a type 2 immune response during which lamina propria ILC2s produce IL-13. This causes epithelial remodelling, including tuft cell hyperplasia with an unknown function. We describe a novel cholinergic effector function of tuft cells, which we show are the only epithelial cells expressing Choline Acetyltransferase (ChAT). During parasite infections, mice with epithelial-specific deletion of ChAT have increased worm burden and faecal egg counts although they are able to mount a comparable type 2 immune response. Mechanistically, IL-13-amplified tuft cells release acetylcholine (ACh) into the gut lumen. We demonstrate a direct effect of ACh on worms, reducing their viability and fecundity via helminth muscarinic ACh receptors, with effects promoted by inhibition of acetylcholinesterase, an helminth-secreted enzyme. Thus, tuft cells are sentinels in naive mice, and their amplification upon helminth infections serves an additional type 2 immune response effector function.

10.1101/2023.12.08.570757

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Expression of the Carcinoembryonic Antigen Gene Is Inhibited by SOX9 in Human Colon Carcinoma Cells

Cancer Research (2005)

Philippe Jay Philippe Berta Philippe Blache

The human carcinoembryonic antigen (CEA) is overexpressed in many types of human cancers and is commonly used as a clinical marker. In colon cancer, this overexpression protects cells against apoptosis and contributes to carcinogenesis. Therefore, CEA-expressing cells as well as CEA expression itself constitute potential therapeutic targets. In this report, we show that the transcription factor SOX9 down-regulates CEA gene expression and, as a probable consequence, induces apoptosis in the human colon carcinoma cell line HT29Cl.16E.

Carcinoembryonic antigen

Colonic Carcinoma

10.1158/0008-5472.can-04-1484

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Citations (58)

Cutaneous Primary Lymphoplasmocytic B-Cell Lymphonw

American Journal of Dermatopathology (1991)

L. Thomas B Ducros C. Hcrmier Philippe Jay M. Dʼlncan

Thomas, L.; Ducros, B.; Hcrmier, C.; Jay, P.; D'lncan, M.; Kanitakis, J.; Bernard, D.; Bignon, J. Y.; Thivolet, J. Author Information

Primary (astronomy)

10.1097/00000372-199104000-00044

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