Ruan Cheko

University Hospital Heidelberg

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Ζoltan Κender

Heidelberg University

Dimitrios Oikonomou

National and Kapodistrian University of Athens

Stefan Kopf

Heidelberg University

Peter P. Nawroth

Heidelberg University

Lars Kihm

Heidelberg University

Thomas Fleming

German Center for Diabetes Research

Jan B. Groener

Schön Klinik Neustadt

Thomas Fleming

Heidelberg University

PP Nawroth

Heidelberg University

Rohini Kuner

Heidelberg University

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Heidelberg University

University Hospital Heidelberg

German Center for Diabetes Research

Deutsches Diabetes-Zentrum e.V.

Heinrich Heine University Düsseldorf

Chirurgische Universitätsklinik Heidelberg

Heidelberg University

Helmholtz Zentrum München

German Cancer Research Center

Diabetes Australia

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Methylglyoxal and Advanced Glycation End Products in Patients with Diabetes – What We Know so Far and the Missing Links

Experimental and Clinical Endocrinology & Diabetes (2017)

Jan B. Groener Dimitrios Oikonomou Ruan Cheko Ζoltan Κender Johanna Zemva

Abstract Hyperglycemia explains the development of late diabetic complications in patients with diabetes type 1 and type 2 only partially. Most therapeutic efforts relying on intensive glucose control failed to decrease the absolute risk for complications by more than 10%, especially in patients with diabetes type 2. Therefore, alternative pathophysiological pathways have to be examined, in order to develop more individualized treatment options for patients with diabetes in the future. One such pathway might be the metabolism of dicarbonyls, among them methylglyoxal and the accumulation of advanced glycation end products. Here we review currently available epidemiological data on dicarbonyls and AGEs in association with human diabetes type 1 and type 2.

Advanced glycation end-product

10.1055/s-0043-106443

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Genetic Polymorphisms of Antioxidant and Antiglycation Enzymes and Diabetic Complications. How Much Can we Learn from the Genes?

Experimental and Clinical Endocrinology & Diabetes (2017)

Dimitrios Oikonomou Jan B. Groener Ruan Cheko Ζoltan Κender Lars Kihm

Abstract There is growing evidence that reactive metabolites, such as reactive oxygen species and dicarbonyls contribute to diabetic complications. Formation, accumulation, and detoxification of these metabolites are controlled by several enzymes, some of which have genetically determined levels of expression or function. This review not only gives an overview of the different SNPs studied in patients with diabetes mellitus type 1 and type 2, but in addition attempts to bridge the gap between a genetic study and clinical use. Therefore, not only the results of the studies are reviewed, but also their use in identification of subgroups where an increased or decreased risk for a diabetic complication is described, as well as their use in developing novel therapeutic options based on understanding the contribution of an enzyme to a given complication.

Detoxification

10.1055/s-0043-106442

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Genetic polymorphisms of antioxidant and antiglycation enzymes and diabetic complications

Dimitrios Oikonomou Jan Gröner Ruan Cheko Ζoltan Κender Lars Kihm

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Skin auto-fluorescence and impairment in thermal sensory testing in diabetes mellitus type 2

Diabetologie und Stoffwechsel (2017)

JB Groener Ruan Cheko Ζoltan Κender Dimitrios Oikonomou Rohini Kuner

HbA1c and glucose control are only in part predicting diabetic polyneuropathy (DPN). In addition, the term "diabetic neuropathy" stands for very different disease entities, affecting the different types of nerve fibers, comprising the sensory-motor- or autonomic nervous system. Therefore we used skin auto-fluorescence, which partially reflects advanced glycation end products (AGE) accumulated in the skin, and quantitative sensory testing (QST), as well as heart rate variability as a surrogate parameter for autonomic neuropathy, to study whether all symptoms of DPN correlate in a similar manner with skin auto-fluorescence in 81 type 2 diabetic patients in a cross-sectional study. All statistical analyses were performed using non-parametric tests, correlations were calculated by Spearman and Kendall tau correlation coefficients.

Diabetic Neuropathy

Quantitative sensory testing

Autonomic nerve

10.1055/s-0037-1601793

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