Sahadevan Seena

University of Coimbra

Author Statistics

Papers

Citation

H-Index

i-10 index

Research Trends

Author Order

Document Type

Co-Authors

Akhilesh Rai

University of Coimbra

Wim Soetaert

Ghent University

Sophie Roelants

Bio Base Europe

Christian V. Stevens

Ghent University

Melike Pala

Ghent University

Lino Ferreira

University of Coimbra

Rafaela Ferrão

University of Coimbra

Cooperative Institutions

Ghent University

Ghent University Hospital

John Wiley & Sons (United States)

Hudson Institute

University of Coimbra

Biocant

Bio Base Europe

Biocat

Bioscience Research

Centro de Neurociências e Biologia Celular

Author Statistics

Papers

Citation

H-Index

i-10 index

Research Field

Acidic sophorolipid and antimicrobial peptide based formulation as antimicrobial and antibiofilm agents

Biomaterials Advances (2023)

Sahadevan Seena Rafaela Ferrão Melike Pala Sophie Roelants Wim Soetaert

Anti-Infective Agents

10.1016/j.bioadv.2023.213299

Cite

Citations (14)

Nanoengineering Approaches to Fight Multidrug-Resistant Bacteria

Sahadevan Seena Akhilesh Rai

In the last few years, a high prevalence of multidrug-resistant (MDR) bacteria, mostly methicillin-resistant Staphylococcus aureus (MRSA), MDR-mycobacterium tuberculosis, and carbapenem-resistant Enterobacteriaceae, has been reported globally. Infections caused by MDR bacteria are difficult to treat and eradicate as they develop resistance by employing novel mechanisms against antibiotics and other antimicrobial agents. Based on the current rate of antibiotic production and approvals by medical regulatory agencies, it is anticipated that approximately ten million people could die annually due to MDR pathogens by year 2050. Therefore, alternative materials, such as the nanoparticles (NPs), antimicrobial peptides (AMPs), and small cationic molecules, have been explored to formulate potent antimicrobial agents to replace antibiotics or reduce the burden of antibiotics from patients. Various compositions of NPs such as metallic, inorganic, organic, and lipid have been synthesized to prepare antimicrobial materials. Antibiotics, AMPs, and small molecules have been conjugated on the surface of NPs to enhance their antimicrobial activities and reduce the systemic cytotoxicity. This book chapter addresses the recent approaches, prospects, and challenges of nanotechnological tools for controlling the transmission and emergence of antibiotic-resistance bacteria.

10.1007/978-981-19-9167-7_9

Cite

Citations (1)