Eugenio V. Fernández‐Aldasoro

Universidad de Cantabria

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José A. Riancho

Marqués de Valdecilla University Hospital

Maria Augusta Alonso

Universidade de São Paulo

Carmen García‐Ibarbia

Marqués de Valdecilla University Hospital

Jana Arozamena

Universidad de Cantabria

José L. Hernández

Universidad de Cantabria

Manuel Sumillera

Marqués de Valdecilla University Hospital

Carlos Garcés

Universidad de Cantabria

Jesús A. Ortiz‐Gómez

Universidad de Cantabria

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Universidad de Cantabria

Marqués de Valdecilla University Hospital

Instituto de Investigación Marqués de Valdecilla

Centre for Biomedical Network Research on Rare Diseases

Instituto de Salud Carlos III

Centro de Investigación Biomédica en Red

Instituto de Investigación de Enfermedades Raras

University of Toronto

Complejo Hospitalario Universitario de Albacete

Hospital Universitario Infanta Cristina

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Aromatase expression in osteoarthritic and osteoporotic bone

Arthritis & Rheumatism (2008)

José L. Hernández Carlos Garcés Manuel Sumillera Eugenio V. Fernández‐Aldasoro Carmen García‐Ibarbia

Abstract Objective Estrogen deprivation is a central mechanism in the development of osteoporosis with aging. Results from recent studies also suggest the involvement of estrogens in the pathophysiology of osteoarthritis (OA). Aromatization of androgenic precursors in peripheral tissue is the main source of estrogens in postmenopausal women and in men. However, the importance of aromatase expression in bone is a subject of controversy. This study was undertaken to determine aromatase expression in bone samples from patients with hip fracture and patients with OA. Methods We studied 104 patients with hip fracture (n = 60) or primary hip OA (n = 44). Aromatase expression was determined in trabecular bone samples from the femoral neck and in osteoblast cultures grown by the primary explant technique (n = 62), using real‐time reverse transcriptase–polymerase chain reaction. Results Aromatase RNA was detected in bone samples at levels similar to those found in adipose tissue. Transcript levels were significantly lower in bone tissue samples obtained from patients with OA than in those obtained from patients with fracture ( P = 0.00001). Likewise, primary cultures of osteoblast cells from OA patients revealed lower aromatase expression than those of cells from fracture patients ( P = 0.012). Results were independent of age or sex differences. Conclusion Our findings indicate that the aromatase gene is expressed in bone tissue in high amounts, similar to those found in adipose tissue, but transcript levels are lower in tissue samples and osteoblast cultures from patients with OA than in those from patients with hip fracture. Since estrogens may help to prevent local cartilage degradation, it can be speculated that such a reduced expression of aromatase could facilitate the development of OA.

Bone tissue

Bone remodeling

10.1002/art.23500

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