Roy J. Duhé

University of Mississippi Medical Center

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William L. Farrar

National Cancer Institute

Bruce R. Selman

University of Wisconsin–Madison

John Kelly Smith

East Tennessee State University

George W. Booz

University of Mississippi Medical Center

Naila M. Mamoon

University of Mississippi Medical Center

Elizabeth Tarsi

University of Tennessee Health Science Center

Robert A. Kirken

The University of Texas at El Paso

Kiranam Chatti

University of Hyderabad

Christopher J. Lahr

University of Mississippi Medical Center

Christian R. Gómez

National Heart Lung and Blood Institute

Cooperative Institutions

University of Mississippi Medical Center

Jackson Memorial Hospital

University of Mississippi

State Street (United States)

National Cancer Institute

National Institutes of Health

Science Applications International Corporation (United States)

Frederick National Laboratory for Cancer Research

Medical College of Wisconsin

University of Washington

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Identification of a redox-sensitive switch within the JAK2 catalytic domain

Free Radical Biology and Medicine (2012)

John Kelly Smith Chetan N. Patil Srikant Patlolla Barak W. Gunter George W. Booz

Dithiothreitol

Alanine

10.1016/j.freeradbiomed.2011.12.025

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Citations (36)

The impact of preventive screening resource distribution on geographic and population-based disparities in colorectal cancer in Mississippi

BMC Research Notes (2015)

Fazlay Faruque Xu Zhang Elizabeth N. Nichols Denae L. Bradley Royce Reeves-Darby

The state of Mississippi has the highest colorectal cancer (CRC) mortality rate in the USA. The geographic distribution of CRC screening resources and geographic- and population-based CRC characteristics in Mississippi are investigated to reveal the geographic disparity in CRC screening. The primary practice sites of licensed gastroenterologists and the addresses of licensed medical facilities offering on-site colonoscopies were verified via telephone surveys, then these CRC screening resource data were geocoded and analyzed using Geographic Information Systems. Correlation analyses were performed to detect the strength of associations between CRC screening resources, CRC screening behavior and CRC outcome data. Age-adjusted colorectal cancer incidence rates, mortality rates, mortality-to-incidence ratios, and self-reported endoscopic screening rates from the years 2006 through 2010 were significantly different for Black and White Mississippians; Blacks fared worse than Whites in all categories throughout all nine Public Health Districts. CRC screening rates were negatively correlated with CRC incidence rates and CRC mortality rates. The availability of gastroenterologists varied tremendously throughout the state; regions with the poorest CRC outcomes tended to be underserved by gastroenterologists. Significant population-based and geographic disparities in CRC screening behaviors and CRC outcomes exist in Mississippi. The effects of CRC screening resources are related to CRC screening behaviors and outcomes at a regional level, whereas at the county level, socioeconomic factors are more strongly associated with CRC outcomes. Thus, effective control of CRC in rural states with high poverty levels requires both adequate preventive CRC screening capacity and a strategy to address fundamental causes of health care disparities.

Sigmoidoscopy

Cancer screening

10.1186/s13104-015-1352-0

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Citations (15)

Tyrosine Kinase Inhibitors

Springer eBooks (2011)

Roy J. Duhé

10.1007/978-3-642-16483-5_6080

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Citations (1)

Koch’s Postulates

Springer eBooks (2011)

Roy J. Duhé

10.1007/978-3-642-16483-5_3242

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Citations (3)

Regulation of the mammalian adenylyl cyclases

Biomembranes (1997)

Roy J. Duhé Andrew H. Dittman Zhiliang Wu Daniel R. Storm

10.1016/s1874-5342(96)80033-x

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Citations (1)

Drug Design

Springer eBooks (2008)

Roy J. Duhé

10.1007/978-3-540-47648-1_1735

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Citations (0)

Barriers and facilitators to cancer clinical trial enrollment and participation among rural populations: a scoping review protocol

JBI Evidence Synthesis (2022)

Michelle Palokas Robin Christian Elizabeth Hinton Roy J. Duhé Toms Vengaloor Thomas

The objective of this scoping review is to identify barriers and facilitators related to cancer clinical trial enrollment and participation among rural populations.Advancing the effectiveness of cancer treatment and increasing early detection of cancer relies on enrollment and participation of individuals in cancer clinical trials. Lack of enrollment and participation in trials is a concern, and there is evidence that individuals living in rural areas are unlikely to participate in such trials. Information on barriers to, and facilitators of, enrollment and participation in cancer clinical trials is needed for the development of evidence-based interventions to increase the enrollment and participation of rural populations.The review will consider studies on adults aged 18 years or older living in rural areas. Studies that report on barriers and facilitators to enrollment and participation in cancer clinical trials, including both cancer therapeutic and cancer early detection trials, will be included in the review. The review will consider quantitative, qualitative, and text and opinion papers for inclusion.The search strategy will aim to locate published primary studies, reviews, and opinion papers, the latter including those by professional oncology organizations. The databases to be searched include MEDLINE, CINAHL, Embase, Web of Science, and Cochrane Library. Gray literature databases will also be searched. Two independent reviewers will retrieve full-text studies and extract data. The results will be presented in diagrammatic format with a narrative summary.

CINAHL

10.11124/jbies-21-00256

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Nitric oxide and thiol redox regulation of Janus kinase activity

Proceedings of the National Academy of Sciences (1998)

Roy J. Duhé Gerald A. Evans Rebecca A. Erwin Robert A. Kirken George W. Cox

The activation of Janus kinases (JAKs) is crucial for propagation of the proliferative response initiated by many cytokines. The proliferation of various cell lines, particularly those of hematopoietic origin, is also modulated by mediators of oxidative stress such as nitric oxide and thiol redox reagents. Herein we demonstrate that nitric oxide and other thiol oxidants can inhibit the autokinase activity of rat JAK2 in vitro , presumably through oxidation of crucial dithiols to disulfides within JAK2. The reduced form of JAK2 is the most active form, and the oxidized JAK2 form is inactive. Nitric oxide pretreatment of quiescent Ba/F3 cells also inhibits the interleukin 3-triggered in vivo activation of JAK2, a phenomenon that correlates with inhibited proliferation. Furthermore, we observed that the autokinase activity of JAK3 responds in a similar fashion to thiol redox reagents in vitro and to nitric oxide donors in vivo . We suggest that the thiol redox regulation of JAKs may partially explain the generally immunosuppressive effects of nitric oxide and of other thiol oxidants.

Thiol

10.1073/pnas.95.1.126

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Citations (150)

The dithiothreitol-stimulated dissociation of the chloroplast coupling factor 1 ϵ-subunit is reversible

Biochimica et Biophysica Acta (BBA) - Bioenergetics (1990)

Roy J. Duhé Bruce R. Selman

Dithiothreitol

10.1016/0005-2728(90)90180-c

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Citations (27)

Thioredoxin-enhanced Janus kinase activity A target for redox-based chemotherapy?

S. Lee Naila M. Mamoon John Kelly Smith Kiranam Chatti Kanakadurga Kundrapu

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