Lung cancer, one of the most malignant tumors, has extremely high morbidity and mortality, posing a serious threat to global health. It is an urgent need to fully understand the pathogenesis of lung cancer and provide new ideas for its treatment. Interestingly, accumulating evidence has identified that transfer RNAs (tRNAs) and tRNA metabolism-associated enzymes not only participate in the protein translation but also play an important role in the occurrence and development of lung cancer. In this review, we summarize the different aspects of tRNA metabolism in lung cancer, such as tRNA transcription and mutation, tRNA molecules and derivatives, tRNA-modifying enzymes, and aminoacyl-tRNA synthetases (ARSs), aiming at a better understanding of the pathogenesis of lung cancer and providing new therapeutic strategies for it.
Objective To study the clinical effect of gluteus maximus muscle-adipofascial turnover flap in the treatment of sacrococcygeal decubitus ulcers.Methods From August 2007 to January 2010,18 cases of sacrococcygeal decubitus ulcers were repaired by gluteus maximus muscle-adipofascial turnover flap.The area of flaps ranged from 5cm×6cm to 7cm×8cm.The wound is then closed with direct polymerizing suture.Results Overall,88% of the flaps (16 of 18) healed primarily.Two patients had early postoperative complications,including wound infection and hematoma.All of these wounds healed with dressing change.Recurrence rate of the study is 5.6 percent.Conclusion Gluteus maximus muscle-adipofascial turnover flap with rich blood supply and high survival percent was a high efficiency approach for filling dead space in repairing sacrococcygeal decubitus ulcers.This method has effect on preventing recurrence of decubitus ulcers after operation.
Herein, a kind of low-κ epoxy composites with excellent comprehensive properties were prepared by introducing chloride salt of octa (aminopropylsilsesquioxane). The dielectric constant (106 Hz) of the composite was decreased by 0.94 when the fillers loading was only 3 wt%. The thermal stability and shore hardness were both improved, and the water adsorption was reduced. The improved properties of the composites were mainly attributed to the intrinsic cage-like structure of the filler and its good dispersion in the matrix. Moreover, the strong interface interaction between the filler and matrix also played an important role.
Background: The clustering of cardiovascular disease (CVD) risk factors has become a major public health challenge worldwide. Although many studies have investigated CVD risk factor clusters, little is known about their prevalence and clustering among medical staff in Northeast China. This study aimed to estimate the prevalence and clustering of CVD risk factors and to investigate the association between relevant characteristics and the clustering of CVD risk factors among medical staff in Northeast China. Methods: A cross-sectional survey of 3720 medical staff from 93 public hospitals in Jilin Province was used in this study. Categorical variables were presented as percentages and were compared using the χ2 test. Multiple logistic regression analysis was used to evaluate the association between relevant characteristics and the clustering of CVD risk factors. Results: The prevalence of hypertension, diabetes, dyslipidemia, being overweight, smoking, and drinking were 10.54%, 3.79%, 17.15%, 39.84%, 9.87%, and 21.75%, respectively. Working in a general hospital, male, and age group 18–44 years were more likely to have 1, 2, and ≥3 CVD risk factors, compared with their counterparts. In particular, compared with being a doctor, being a nurse or medical technician was less likely to have 1, 2, and ≥3 CVD risk factors only in general hospitals. Conclusions: The findings suggest that medical staff of general hospitals, males, and older individuals have a high chance associated with CVD risk factor clustering and that more effective interventions should be undertaken to reduce the prevalence and clustering of CVD risk factors, especially among older male doctors who work in general hospitals.
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