John P. Giesy

Research Field

Polybrominated diphenyl ethers (PBDEs) have been widely used as flame retardants. The structurally related hydroxylated PBDEs (OH-PBDEs) and methoxylated PBDEs (MeO-PBDEs) occur in precipitation, surface water, wildlife, and humans. The formation of OH-PBDEs in wildlife and humans is of considerable concern due to their greater toxicities relative to PBDEs and MeO-PBDEs. Research to date suggests that OH-PBDEs are formed by hydroxylation of PBDEs, and MeO-PBDEs are then formed by methylation of the OH-PBDEs. Here we show significant metabolic production of OH-PBDEs from MeO-PBDEs while hydroxylation of synthetic PBDEs to OH-PBDEs was negligible. Concentrations of PBDEs, OH-PBDEs, and MeO-PBDEs were analyzed in tuna, albatross, and polar bears collected from marine environments worldwide, and we found a closer relationship between OH-PBDEs and MeO-PBDEs than had been previously reported. Furthermore, for the first time the metabolic relationships between PBDEs, OH-PBDEs, and MeO-PBDEs were elucidated in vitro using rainbow trout, chicken, and rat microsomes. We propose the production of OH-PBDEs from naturally occurring MeO-PBDEs as a previously unidentified mechanism that could be an important contributor for the occurrence of OH-PBDEs found in wildlife from remote areas. Our results suggest that risk assessment paradigms for PBDEs and their metabolites need reevaluation and that human exposure to MeO-PBDEs that occur naturally in marine organisms should be considered.

10.1021/es901357u

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Citations (226)

Perfluoroalkyl and polyfluoroalkyl substances in sediments from South Bohai coastal watersheds, China

Marine Pollution Bulletin (2014)

Zhaoyun Zhu Tieyu Wang Pei Wang Yonglong Lü John P. Giesy

10.1016/j.marpolbul.2013.12.042

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Citations (55)

In situ effects of urban river pollution on the mudsnail Potamopyrgus antipodarum as part of an integrated assessment

Aquatic Toxicology (2014)

Radka Zounková Veronika Jálová Martina Janisova Tomáš Ocelka Jana Jurčíková

10.1016/j.aquatox.2014.02.021

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Citations (17)

Temporal and spatial differences in deposition of organic matter and black carbon in Lake Michigan sediments over the period 1850–2010

Journal of Great Lakes Research (2018)

Solidea Bonina Garry Codling Margaret B. Corcoran Jiehong Guo John P. Giesy

Deposition

Sedimentation

10.1016/j.jglr.2018.03.001

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Citations (17)

Identification and response to metals of metallothionein in two ancient fishes: White sturgeon (Acipenser transmontanus) and lake sturgeon (Acipenser fulvescens)

Comparative Biochemistry and Physiology Part C Toxicology & Pharmacology (2015)

Jon A. Doering Shawn C. Beitel Bryanna K. Eisner Timon Heide Henner Hollert

Lake sturgeon

Metallothionein

10.1016/j.cbpc.2015.03.002

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Citations (29)

Toxicity of untreated and ozone-treated oil sands process-affected water (OSPW) to early life stages of the fathead minnow (Pimephales promelas)

Water Research (2012)

Yuhe He Sarah Patterson Nan Wang Markus Hecker Jonathan W. Martin

Pimephales promelas

10.1016/j.watres.2012.09.004

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Citations (156)

Ball milling synthesis of covalent organic framework as a highly active photocatalyst for degradation of organic contaminants

Journal of Hazardous Materials (2019)

Hongzhou Lv Xiaoli Zhao Hongyun Niu Sijing He Zhi Tang

Photodegradation

10.1016/j.jhazmat.2019.02.046

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Citations (154)

Organochlorine pesticides (HCHs and DDTs) in soils along the north coastal areas of the Bohai Sea, China

Chemistry and Ecology (2010)

Wenyou Hu Tieyu Wang Jong Seong Khim Wei Luo Wentao Jiao

A systematic survey of organochlorine pesticides (OCPs) including hexachlorocyclohexane isomers (α-HCH, β-HCH, γ-HCH, δ-HCH and ΣHCH) and dichlorodiphenyltrichloroethane metabolites (p,p′-DDT, p,p′-DDE, o,p′-DDT, p,p′-DDD and ∑DDT) in soils along the north coastal areas of the Bohai Sea, China, has been lacking. In this study, 31 representative surface soil samples were collected along the north coastal and riverine areas of the Bohai Sea to characterise the potential for adverse effects of ∑HCH, ∑DDT and their individual isomers and transformation products. Concentrations of ΣHCH and ΣDDT in soils ranged from less than the limit of detection (

Hexachlorocyclohexane

Lindane

10.1080/02757540.2010.504664

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Citations (16)

Metals associated with organic carbon extracted from Okefenokee Swamp water

Chemical Geology (1977)

John P. Giesy Linda A. Briese

Swamp

Ultrafiltration (renal)

Fraction (chemistry)

Carbon fibers