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Olga E. Andreeva

Ministry of Health of the Russian Federation

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Alexander M. Scherbakov

N. I. Lobachevsky State University of Nizhny Novgorod

Danila V. Sorokin

Ministry of Health of the Russian Federation

И. В. Заварзин

N.D. Zelinsky Institute of Organic Chemistry

Krasil'nikov Ma

Ministry of Health of the Russian Federation

Валерий З. Ширинян

N.D. Zelinsky Institute of Organic Chemistry

Diana I. Salnikova

Ministry of Health of the Russian Federation

Svetlana K. Vorontsova

N.D. Zelinsky Institute of Organic Chemistry

Yuri Y. Shchegolev

Ministry of Health of the Russian Federation

Eugene I. Bozhenko

N.D. Zelinsky Institute of Organic Chemistry

Mikhail E. Minyaev

N.D. Zelinsky Institute of Organic Chemistry

Cooperative Institutions

Russian Academy of Sciences

Ministry of Health of the Russian Federation

Russian Cancer Research Center NN Blokhin

N.D. Zelinsky Institute of Organic Chemistry

Lomonosov Moscow State University

Academy of Medical Sciences

National Academy of Sciences of Belarus

National Medical Research Center of Cardiology

Ministry of Health

Sechenov University

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191 The sensitivity of hormone-resistant breast cancer cells to doxorubicin: the role of NF-kappa B signaling

European Journal of Cancer Supplements (2010)

Alexander M. Scherbakov Yulia S. Lobanova Olga E. Andreeva V. A. Shatskaya Krasil'nikov Ma

Insulin aspart

Insulin detemir

Insulin lispro

Tolerability

Insulin analog

10.1016/s1359-6349(10)70221-4

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CHANGES IN DNA METHYLATION PROFILE IN TAMOXIFEN-RESISTANT MCF-7 SUBLINES

Siberian Journal of Oncology (2019)

Olga E. Andreeva В.О. Сигин V. V. Strelnikov А. С. Танас Alexander M. Scherbakov

Abstract Introduction. We have previously shown the feasibility of hormonal resistance horizontal distribution from cell to cell, with the joint cultivation of sensitive and resistant cells and/or through exosomes secreted by resistant cells. What is the mechanism of such resistance distribution, and how do cells with secondary resistance reproduce the characteristics of donor resistant cells? To answer these questions, we analyzed the overall level of DNA methylation in MCF-7 estrogen-dependent breast cancer cells and estrogen-independent sublinia. The purpose of the study was to analyze DNA methylation profiles for the development of hormonal resistance by breast cancer cells and for resistant phenotype further accession. Methods. DNA methylation was evaluated by the RRBS (Reduced Representation Bisulfite Sequencing) method in MCF-7 breast cancer cells and their resistant sublines. Results. 19 CpG dinucleotides, differentially and generally unidirectionally methylated in cells with primary and secondary resistance to tamoxifen, were detected. Differential changes in methylation were found for DNA regions that regulated the expression of six protein-coding genes: PRKCZ, TRAPPC9, AS IC2, C2CD4A, ZNF787, CRTAC 1. Bioinformatics analysis showed that two of these six genes, PRKCZ (protein kinase C Zeta) and TRAPPC9 (Trafficking Protein Particle Complex Subunit 9) were directly involved in the regulation of NF-κB activity. Conclusion. The data obtained indicate the existence of common DNA patterns, the methylation of which varies in the same direction in cells with primary and secondary resistance. The involvement of two of the identified genes in the regulation of NF-κB may indicate the inclusion of the latter in the formation of a resistant phenotype of tumor cells, even under conditions of horizontal transfer of resistance.

MCF-7

CpG site

Bisulfite sequencing

10.21294/1814-4861-2019-18-5-45-53

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АПИГЕНИН ИНГИБИРУЕТ РОСТ КЛЕТОК РАКА МОЛОЧНОЙ ЖЕЛЕЗЫ: РОЛЬ ERα И HER2/NEU

Acta Naturae (2015)

A. M. Shcherbakov Olga E. Andreeva

HER2/neu

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270 The NF-kappa B Signalling Pathway and the Response to Doxorubicin in Hormone-resistant Breast Cancer Cells

European Journal of Cancer (2012)

Alexander M. Scherbakov Yulia S. Lobanova Olga E. Andreeva V. A. Shatskaya Krasil'nikov Ma

Signalling

Kappa

Signalling pathways

10.1016/s0959-8049(12)70337-4

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Effect of the exosome-mediated suppression of the estrogen signaling: the role in the progression of the hormonal resistance of breast cancer cells

Advances in molecular oncology (2020)

Danila V. Sorokin Olga E. Andreeva Ekaterina I. Mikhaevich Yuri Y. Shchegolev Alexander M. Scherbakov

The most effective treatment of the hormone-dependent breast cancer is based on the antiestrogens SERM and aromatase inhibitor treatment, however its efficiency is limited by the acquired resistance to the drugs. Previously we have revealed the effect of the transferring of the hormonal resistance from the resistant to the sensitive cells under in vitro cell co-cultivation, and demonstrated exosomes involvement in this process. Here we have shown that the exosomes of the resistant cells caused the marked inhibition of the estrogen signaling in the recipient cells, and identified microRNAs – ERα suppressors that overexpressed in the resistant exosomes. Taken together, the results obtained demonstrate the important role of the estrogen signaling suppression in the exosome-induced transferring of the hormonal resistance, and revealed the involvement of the exosomal microRNA in the ERα down-regulation.

Exosome

Cell Signaling

10.17650/2313-805x-2020-7-3-58-62

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CCDC 1495042: Experimental Crystal Structure Determination

The Cambridge Structural Database (2017)

Yu. V. Kuznetsov И. С. Левина Alexander M. Scherbakov Olga E. Andreeva Irina V. Fedyushkina

An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.

Crystal (programming language)

10.5517/ccdc.csd.cc1m5q5p

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Steroidal N-Sulfonylimidates: Synthesis and biological evaluation in breast cancer cells

European Journal of Medicinal Chemistry (2019)

Yulia A. Volkova Andrey S. Kozlov Marya K. Kolokolova Denis Y. Uvarov Sergey A. Gorbatov

10.1016/j.ejmech.2019.06.048

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72P Targeting androgen receptor splice variant 7 in 22Rv1 prostate cancer cells

Annals of Oncology (2021)

Alexander M. Scherbakov M. Barysevich M. Laktsevich-Iskryk Olga E. Andreeva Danila V. Sorokin

splice

10.1016/j.annonc.2021.08.2068

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New estrogen receptor antagonists. 3,20-Dihydroxy-19-norpregna-1,3,5(10)-trienes: Synthesis, molecular modeling, and biological evaluation

European Journal of Medicinal Chemistry (2017)

Yu. V. Kuznetsov И. С. Левина Alexander M. Scherbakov Olga E. Andreeva Irina V. Fedyushkina

Methylene

Molecular model

Demethylation

10.1016/j.ejmech.2017.11.042

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Citations (18)

Antiestrogenic and antiproliferative potency of secoisolariciresinol diglucoside derivatives on MCF-7 breast cancer cells

Natural Product Research (2020)

Alexander M. Scherbakov О. В. Стасевич Diana I. Salnikova Olga E. Andreeva Ekaterina I. Mikhaevich

Secoisolariciresinol diglucoside (SDG) is isolated from Linum usitatissimum seeds. The antiproliferative effects of SDG (1) and its derivatives secoisolariciresinol (2) and secoisolariciresinol-4', 4″-diacetate (3) have been evaluated on MCF-7 breast cancer cells and normal breast epithelial line MCF-10A. Lignan 1 has not shown cytotoxic effects on MCF-7 cells, while derivatives 2 and 3 have inhibited cell growth with IC50 values of 25 and 11 µM, respectively. Estrogen receptor alpha is a key growth driver in MCF-7 cells. Compound 1 did not affect the activity of ERα, while derivatives 2 and 3 showed significant antiestrogenic effects. Compounds 2 and 3 caused apoptosis in the MCF-7 line, determined by the cleavage of PARP. SDG derivative 3 enhanced the effect of doxorubicin. SDG derivatives can be considered as promising agents that exhibit a combined antiestrogen and proapoptotic effect in hormone-dependent breast cancer cells.

MCF-7

Antiestrogen

10.1080/14786419.2020.1826479

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Citations (22)

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