Sonja Mayer

University of Tübingen

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Benjamin List

Max-Planck-Institut für Kohlenforschung

Friedrich Götz

University of Tübingen

Ralph Bertram

Nuremberg Hospital

Antti Vasala

Tampere University

Melanie Kull

University of Tübingen

Wojtek Steffen

University of Hohenheim

Peter Neubauer

Technische Universität Berlin

Julia Steuber

University of Hohenheim

Kaisa Ukkonen

University of Oulu

Florian Glauche

Technische Universität Berlin

Cooperative Institutions

University of Tübingen

University of Konstanz

Universitätsklinikum Tübingen

Institute of Medical Microbiology and Hygiene

University of Hohenheim

Technische Universität Berlin

Czech Academy of Sciences, Institute of Microbiology

Czech Academy of Sciences, Institute of Biotechnology

Max Planck Institute of Quantum Optics

Ludwig-Maximilians-Universität München

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Both Terminal Oxidases Contribute to Fitness and Virulence during Organ-Specific Staphylococcus aureus Colonization

mBio (2013)

Friedrich Götz Sonja Mayer

In their recent article, Hammer et al. (N. D. Hammer, M. L. Reniere, J. E. Cassat, Y. Zhang, A. O. Hirsch, M. Indriati Hood, and E. P. Skaar, mBio 4:e00241-13, 2013) described the dual functions of the two terminal oxidases encoded by cydBA and qoxABCD in Staphylococcus aureus. The aerobic growth of cydB or qoxB single mutant bacteria was barely affected. However, a cydB qoxB double mutant was completely unable to respire and exhibited the small-colony variant phenotype that is typical of menaquinone and heme biosynthesis mutants. The authors found that the two terminal oxidases play a role in pathogenesis. In a systemic mouse infection model, it turned out that in the cydB mutant the bacterial burden was significantly decreased in the heart, kidneys, and liver, while in the qoxB mutant it was decreased only in the liver. These results illustrate that both terminal oxidases contribute to fitness and virulence, representing promising candidates for the development of antimicrobials.

10.1128/mbio.00976-13

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Citations (34)

The breakdown flash of silicon avalanche photodiodes--back door for eavesdropper attacks?

Journal of Modern Optics (2001)

P. Zarda Sonja Mayer Christian Kurtsiefer Harald Weinfurter

Avalanche breakdown

Single-photon avalanche diode

Avalanche diode

10.1080/09500340110070235

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Citations (17)

Vectors for improved Tet repressor-dependent gradual gene induction or silencing in Staphylococcus aureus

Microbiology (2011)

Leonie Helle Melanie Kull Sonja Mayer Gabriella Marincola Marc-Eric Zelder

A set of vectors for improved tetracycline-dependent gene regulation in Staphylococcus aureus is presented. Plasmid pRAB11 was generated from pRMC2 by adding a second tet operator within the TetR-regulated promoter P xyl/tet . Pronounced repression was observed in the absence of anhydrotetracycline (ATc) combined with high induction in the presence of the drug, as demonstrated for pRAB11 bearing staphylococcal nuclease nuc1 , lacZ or gfp . Also, in plasmid pCG261, the pRAB11 tetR –P xyl/tet regulatory architecture permitted tight repression and a stepwise increase in transcript amounts of the target gene rny (putative RNase) correlated with rising ATc concentrations. Additionally, pRAB11-derived vectors harbouring semi-rationally designed P xyl/tet -like fragments, mutated at up to six defined positions, were constructed. Sixteen mutant sequences with single to quadruple exchanges were analysed for transcriptional strength and ATc-dependent inducibility. A set of promoters with gradually decreased activities and improved repression is presented. Finally, the implementation of reverse TetR revtetR-r2 , which exhibits three amino acid exchanges and binds to tetO in the presence of ATc, yielded an efficiently co-repressible vector within the pRAB11 system. Intriguingly, revtetR was found to contain a fourth mutation only after propagation in S. aureus . We predict that the described vectors constitute valuable tools for staphylococcal genetics.

TetR

10.1099/mic.0.052548-0

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Role of the Na + -translocating NADH:quinone oxidoreductase in voltage generation and Na + extrusion in Vibrio cholerae

Biochimica et Biophysica Acta (BBA) - Bioenergetics (2015)

Thomas Vorburger Ruslan Nedielkov Alexander Brosig Eva Bok Emina Schunke

Antiporters

10.1016/j.bbabio.2015.12.010

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Inhibition of microbial production of the malodorous substance isovaleric acid by 4,4ʹ dichloro 2‐hydroxydiphenyl ether (DCPP)

MicrobiologyOpen (2021)

Sonja Mayer M.F. Hazenkamp Martin Kluttig Dietmar Ochs

Abstract Human body malodour is a complex phenomenon. Several types of sweat glands produce odorless secretions that are metabolized by a consortium of skin‐resident microorganisms to a diverse set of malodorous substances. Isovaleric acid, a sweaty‐smelling compound, is one major malodorous component produced by staphylococci with the skin‐derived amino acid L‐leucine as a substrate. During wearing, fabrics are contaminated with sweat and microorganisms and high humidity propagates growth and microbial malodour production. Incomplete removal of sweat residues and microorganisms from fabrics during laundry with bleach‐free detergents and at low temperatures elevate the problem of textile malodour. This study aimed to analyze the inhibitory effect of the antimicrobial 4,4ʹ dichloro 2‐hydroxydiphenyl ether (DCPP) on the formation of isovaleric acid on fabrics. Therefore, GC‐FID‐ and GC–MS‐based methods for the analysis of isovaleric acid in an artificial human sweat‐mimicking medium and in textile extracts were established. Here, we show that antimicrobials capable to deposit on fabrics during laundry, such as DCPP, are effective in growth inhibition of typical malodour‐generating bacteria and prevent the staphylococcal formation of isovaleric acid on fabrics in a simple experimental setup. This can contribute to increased hygiene for mild laundry care approaches, where bacterial contamination and malodour production represent a considerable consumer problem.

Laundry

10.1002/mbo3.1174

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Citations (4)

Asymmetrische Gegenanion‐vermittelte Katalyse

Angewandte Chemie (2006)

Sonja Mayer Benjamin List

Außerordentlich hohe Enantioselektivitäten können auch dann erzielt werden, wenn nur das Anion eines Katalysatorsalzes chiral ist. Ein aus einem achiralen Ammonium-Kation und einem chiralen Phosphat-Anion zusammengesetztes Salz (1) katalysiert die asymmetrische Transferhydrierung von aromatischen und aliphatischen α,β-ungesättigten Aldehyden in Gegenwart eines Hantzsch-Esters mit ausgezeichneten Enantioselektivitäten (siehe Schema).

10.1002/ange.200600512

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Citations (204)

Lactose autoinduction with enzymatic glucose release: Characterization of the cultivation system in bioreactor

Protein Expression and Purification (2013)

Sonja Mayer Stefan Junne Kaisa Ukkonen Julia Glazyrina Florian Glauche

10.1016/j.pep.2013.10.024

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Citations (17)

Asymmetric Counteranion‐Directed Catalysis

Angewandte Chemie International Edition (2006)

Sonja Mayer Benjamin List

Exceedingly high enantioselectivity in a catalytic reaction can be realized even when the chirality resides only in the counteranion of the catalyst. A salt (1) composed of an achiral ammonium cation and a chiral phosphate counteranion catalyzes asymmetric transfer hydrogenations of aromatic and aliphatic α,β-unsaturated aldehydes with a Hantzsch ester in excellent enantioselectivities (see scheme).

Chirality

10.1002/anie.200600512

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Citations (532)

Bewerberseitige Akzeptanz von Personalauswahlverfahren

Der Betriebswirt (2017)

Stefan Huf Sonja Mayer

Im Rahmen der Personalauswahl erfolgt nicht nur eine arbeitgeberseitige Eignungsprüfung der Bewerber, sondern auch eine bewerberseitige Entscheidung für den Arbeitgeber. Diese Entscheidung wird maßgeblich davon beeinflusst, wie Bewerber den Recruitingprozess erleben. Der Beitrag bilanziert daher den Stand der Forschung hinsichtlich der bewerberseitigen Akzeptanz von Personalauswahlverfahren und zeigt Implikationen für die betriebliche Praxis auf. Within staffing not only employer select applicants, employers are chosen by applicants as well. How applicants experience the recruiting process affects their decision to accept an offered job. Therefore the paper recaps theory and research on applicants perceptions of selection procedures and identifies managerial implications. Keywords: soziale validität, fairness, eignung, auswahlprozess

Staffing

10.3790/dbw.58.3.16

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Citations (1)

The Staphylococcus aureus NuoL-Like Protein MpsA Contributes to the Generation of Membrane Potential

Journal of Bacteriology (2014)

Sonja Mayer Wojtek Steffen Julia Steuber Friedrich Götz

In aerobic microorganisms, the entry point of respiratory electron transfer is represented by the NADH:quinone oxidoreductase. The enzyme couples the oxidation of NADH with the reduction of quinone. In the type 1 NADH:quinone oxidoreductase (Ndh1), this reaction is accompanied by the translocation of cations, such as H(+) or Na(+). In Escherichia coli, cation translocation is accomplished by the subunit NuoL, thus generating membrane potential (Δψ). Some microorganisms achieve NADH oxidation by the alternative, nonelectrogenic type 2 NADH:quinone oxidoreductase (Ndh2), which is not cation translocating. Since these enzymes had not been described in Staphylococcus aureus, the goal of this study was to identify proteins operating in the NADH:quinone segment of its respiratory chain. We demonstrated that Ndh2 represents a NADH:quinone oxidoreductase in S. aureus. Additionally, we identified a hypothetical protein in S. aureus showing sequence similarity to the proton-translocating subunit NuoL of complex I in E. coli: the NuoL-like protein MpsA. Mutants with deletion of the nuoL-like gene mpsA and its corresponding operon, mpsABC (mps for membrane potential-generating system), exhibited a small-colony-variant-like phenotype and were severely affected in Δψ and oxygen consumption rates. The MpsABC proteins did not confer NADH oxidation activity. Using an Na(+)/H(+) antiporter-deficient E. coli strain, we could show that MpsABC constitute a cation-translocating system capable of Na(+) transport. Our study demonstrates that MpsABC represent an important functional system of the respiratory chain of S. aureus that acts as an electrogenic unit responsible for the generation of Δψ.

10.1128/jb.02127-14

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Citations (39)