Raúl Galera

Hospital Universitario La Paz

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Francisco García‐Río

Hospital Universitario La Paz

Raquel Casitas

Hospital Universitario La Paz

Elisabet Martínez-Cerón

Hospital Universitario La Paz

Carolina Cubillos‐Zapata

Centre for Biomedical Network Research on Rare Diseases

Elena Díaz‐García

Centro de Investigación Biomédica en Red de Enfermedades Respiratorias

Ester Zamarrón

Hospital Universitario La Paz

Enrique Alfaro

Hospital Universitario La Paz

Sara García-Tovar

Hospital Universitario La Paz

Isabel Torres

Universidad de Santiago de Chile

Carlos Carpio

Universidad Autónoma de Madrid

Cooperative Institutions

Hospital Universitario La Paz

108

Universidad Autónoma de Madrid

Centro de Investigación Biomédica en Red de Enfermedades Respiratorias

Hospital La Paz Institute for Health Research

Centro de Investigación Biomédica en Red

Instituto de Salud Carlos III

Centre for Biomedical Network Research on Rare Diseases

Universidad Complutense de Madrid

Centro de Investigación en Red en Enfermedades Cardiovasculares

Respiratory Clinical Trials

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Increased Blood Eosinophil Count Is Related to Less Daily Physical Activity in Patients With Chronic Obstructive Pulmonary Disease

Archivos de Bronconeumología (2022)

Raúl Galera Cristina Mergelina Raquel Casitas Elisabet Martínez-Cerón Francisco García‐Río

10.1016/j.arbres.2022.06.005

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Citations (1)

Identification of non-coding genetic variants in samples from hypoxemic respiratory disease patients that affect the transcriptional response to hypoxia

Nucleic Acids Research (2016)

O. Roche María Laura Deguiz María Tiana Clara Galiana-Ribote Daniel Martinez-Alcazar

A wide range of diseases course with an unbalance between the consumption of oxygen by tissues and its supply. This situation triggers a transcriptional response, mediated by the hypoxia inducible factors (HIFs), that aims to restore oxygen homeostasis. Little is known about the inter-individual variation in this response and its role in the progression of disease. Herein, we sought to identify common genetic variants mapping to hypoxia response elements (HREs) and characterize their effect on transcription. To this end, we constructed a list of genome-wide HIF-binding regions from publicly available experimental datasets and studied the genetic variability in these regions by targeted re-sequencing of genomic samples from 96 chronic obstructive pulmonary disease and 144 obstructive sleep apnea patients. This study identified 14 frequent variants disrupting potential HREs. The analysis of the genomic regions containing these variants by means of reporter assays revealed that variants rs1009329, rs6593210 and rs150921338 impaired the transcriptional response to hypoxia. Finally, using genome editing we confirmed the functional role of rs6593210 in the transcriptional regulation of EGFR. In summary, we found that inter-individual variability in non-coding regions affect the response to hypoxia and could potentially impact on the progression of pulmonary diseases.

Hypoxia

Coding region

10.1093/nar/gkw811

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Citations (12)

Cost-Effectiveness Analysis of 3 Methacholine Challenge Tests: Importance of Simplified Protocols

Journal of Investigational Allergology and Clinical Immunology (2016)

Elisabet Martínez-Cerón Ana Muñoz Garcia Raquel Casitas Raúl Galera Francisco García‐Río

Methacholine

10.18176/jiaci.0026

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TGF-β1 Overexpression in Severe COVID-19 Survivors: Implications for Early-Phase Fibrotic Abnormalities and Long-Term Functional Impairment

Enrique Alfaro Garcia Raquel Casitas Elena Díaz‐García Sara García-Tovar Raúl Galera

Functional impairment

10.1183/13993003.congress-2024.pa5300

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Endothelial Dysfunction and Persistent Inflammation in Severe Post-COVID-19 Patients: Implications for Gas Exchange

Enrique Alfaro Garcia Elena Díaz‐García Sara García-Tovar Raúl Galera Raquel Casitas

Endothelial Dysfunction

2019-20 coronavirus outbreak

10.1183/13993003.congress-2024.pa5301

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Dynamic hyperinflation in patients with asthma and exercise-induced bronchoconstriction

Annals of Allergy Asthma & Immunology (2017)

Olga Mediano Raquel Casitas Carlos Villasante Elisabet Martínez-Cerón Raúl Galera

Dynamic hyperinflation

Vital capacity

Hyperinflation

Bronchial hyperresponsiveness

10.1016/j.anai.2017.01.005

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Citations (11)

Fibrosis quística

DELETED (2009)

Chiriboga Sánchez Carlos Carpio Raúl Galera E. Martínez C. Llontop Guzmán

10.1016/s1576-9895(09)70052-9

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Prediction of postoperative lung function after major lung resection for lung cancer using volumetric computed tomography

Journal of Thoracic and Cardiovascular Surgery (2018)

Lucía Fernández-Rodríguez Isabel Torres D. Romera Raúl Galera Raquel Casitas

10.1016/j.jtcvs.2018.07.040

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Citations (22)

Influencia del astigmatismo refractivo en la calidad óptica ocular en pacientes con cataratas

Raúl Galera

La primera causa de perdida de vision en el mundo es debido a la catarata, induce una disminucion de la funcion visual debido a una opacificacion del cristalino. En las consultas oftalmologicas se diagnostican las cataratas mediante procesos procesos subjetivos como son la toma de la agudeza visual y la gradacion de la opacidad del cristalino observada con biomicroscopia (proceso subjetivo donde segun el criterio y la experiencia del oftalmologo son fundamentales). La valoracion subjetiva de pacientes con cataratas y astigmatismo realizada en este estudio, ha sido valorada mediante un instrumento basado en la tecnica de doble paso y la gradacion subjetiva mediante la escala internacional estandarizada Lens Opacities Classification System III (LOCS II). La tecnica de doble paso se ha hecho por medio del instrumento Optical Quality Analysis System (OQAS) que nos proporciona el parametro OSI (indice de dispersion optica), el cual mide la dispersion de la luz a traves de la imagen de un punto que es reflejada por la retina. Se han analizado 98 ojos y la toma de muestras se realizo en el Consorci Sanitari de Terrassa. Los resultados de este estudio, muestra que OSI es un buen parametro objetivo para clasificar y gradar cataratas con astigmatismo y en cambio otros parametros de calida optica no obtenemos valores significativos.

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Effect of CPAP on Glycemic Control in Patients with Obstructive Sleep Apnea and Type 2 Diabetes. A Randomized Clinical Trial.

American Journal of Respiratory and Critical Care Medicine (2016)

Elisabet Martínez-Cerón Beatriz Barquiel Bezos Am Raquel Casitas Raúl Galera

Abstract Obstructive sleep apnea (OSA) is a risk factor for type 2 diabetes that adversely impacts glycemic control. However, there is little evidence about the effect of continuous positive airway pressure (CPAP) on glycemic control in diabetic patients. To assess the effect of CPAP on glycated hemoglobin (HbA1c) levels in patients with suboptimally controlled type 2 diabetes and OSA, and to identify its determinants. In a 6-month, open-label, parallel, and randomized clinical trial, 50 patients with OSA and type 2 diabetes and two HbA1c levels ≥ 6.5% were randomized to CPAP (n=26) or no CPAP (control; n=24), while their usual medication for diabetes remained unchanged. HbA1c levels, scores of the Homeostasis Model Assessment (HOMA) and Qualitative Insulin Sensitivity Check Index (QUICKI), systemic biomarkers and health-related quality of life were measured at 3 and 6 months. After 6 months, the CPAP group achieved a greater decrease in HbA1c levels compared with the control group. Insulin resistance and sensitivity measurements (in noninsulin users) and serum levels of IL-1β, IL-6 and adiponectin also improved in the CPAP group compared with the control group after 6 months. In the patients treated with CPAP, mean nocturnal oxygen saturation and baseline IL-1β were independently related with 6-month change in HbA1c levels (r2=0.510, P=0.002). Among patients with suboptimally controlled type 2 diabetes and OSA, CPAP treatment for 6 months, when compared to a control group, resulted in improved glycemic control and insulin resistance. Clinical trial registration available at www.clinicaltrials.gov, ID NCT01801150.

Glycated hemoglobin

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Citations (12)