Vivek Ranjan Sinha

Panjab University

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Rachna Kumria

Maharishi Markandeshwar University, Mullana

Amita Sarwal

Panjab University

Karan Razdan

Panjab University

Sumit Sharma

Indian Agricultural Research Institute

Rakesh Kumar

Indian Institute of Technology Kanpur

Rajiv Kumar

Army Hospital Research and Referral

J. R. Bhinge

Panjab University

Honey Goel

AstraZeneca (Japan)

Lalita Dahiya

Panjab University

Mahendra Singh

Yeungnam University

Cooperative Institutions

Panjab University

Post Graduate Institute of Medical Education and Research

Chandigarh University

University of the Punjab

Institute of Post Graduate Medical Education and Research

Banaras Hindu University

Institute of Medical Sciences

National Defence University of Malaysia

All India Institute of Medical Sciences

Karnavati University

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Permeation Enhancers for Transdermal Drug Delivery

Drug Development and Industrial Pharmacy (2000)

Vivek Ranjan Sinha Maninder Kaur

The transdermal route has been recognized as one of the highly potential routes of systemic drug delivery and provides the advantage of avoidance of the first-pass effect, ease of use and withdrawal (in case of side effects), and better patient compliance. However, the major limitation of this route is the difficulty of permeation of drug through the skin. Studies have been carried out to find safe and suitable permeation enhancers to promote the percutaneous absorption of a number of drugs. The present review includes the classification of permeation enhancers and their mechanism of action; thus, it will help in the selection of a suitable enhancer(s) for improving the transdermal permeation of poorly absorbed drugs.

10.1081/ddc-100100984

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Citations (232)

In Situ Forming Depot as Sustained-Release Drug Delivery Systems

Critical Reviews in Therapeutic Drug Carrier Systems (2018)

Navjot Kanwar Vivek Ranjan Sinha

In situ forming systems can serve as promising alternative to existing long acting injectables like disperse systems and microspheres, owing to their biocompatibility, stability, ease of administration and scale up. Microspheres based on long-acting parenteral systems pose challenges in scaling up and process changes with the drug and polymer selected. In situ gelling systems are having low viscosity which is very conducive during various manufacturing unit operations and passing the formulation through hypodermic needle with lower applied pressure. Different mechanisms such as physical or physiological stimuli and cross linking reactions are involved in the gelling of in situ forming systems at the site of injection. Drug release from in situ forming systems can be altered according to the need by using different polymers, lipids and fatty acids. In situ forming systems can be evaluated by sol-gel transition time, temperature and pH, rheology, gel strength, texture analysis, syringeability and injectability. The present paper is an overview of the various in situ gelling polymers and their application in the preparation of depot formulations. Numerous products based on in situ forming systems such as Eligard®, Atridox® are available in market.

Depot

Biocompatibility

10.1615/critrevtherdrugcarriersyst.2018025013

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Citations (49)

Contributors

Elsevier eBooks (2020)

Salvana Priscylla Manso Costa J. Dias-Ferreira A.R. Fernandes Rohit C. Ghan Randeep Kaur

10.1016/b978-0-12-817870-6.01002-6

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List of contributors

Elsevier eBooks (2022)

Hafsat Abdulkarim Adamu Abdullahi Lawrence Boluwatife Afolabi Basiru Olaitan Ajiboye Bushra Akhtar

10.1016/b978-0-12-824408-1.00008-9

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Binders for colon specific drug delivery: an in vitro evaluation

International Journal of Pharmaceutics (2002)

Vivek Ranjan Sinha Rachna Kumria

Guar gum

Enteric coating

10.1016/s0378-5173(02)00398-8

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Citations (112)

Development of Pulsatile Systems for Targeted Drug Delivery of Celecoxib for Prophylaxis of Colorectal Cancer

Drug Delivery (2006)

Vivek Ranjan Sinha J. R. Bhinge Rachna Kumria Manoj Kumar

The aim of the present study was to formulate fast release enteric-coated tablets for drug delivery to the colon. Two different approaches were used for the preparation of these tablets. The first included making use of superdisintegrant (SD) in the tablet. The amount of super disintegrant (cross-linked PVP) in the tablet and the coat weight were varied to formulate a suitable time-controlled release system, that would provide colon-specific drug delivery. The second approach consisted of development of osmogen-based tablets for drug delivery into the tracts of the colon. Two different osmogens, sodium chloride and potassium chloride, were used. These also were coated at different coat levels. Celecoxib was used as a model drug. In vitro drug release studies showed that superdisintegrants were more effective in showing burst effect in the tablets and therefore showed a rapid drug release as compared with osmogens, which would show a sustained drug release all through the colon. Osmotic tablets were formulated making use of a high concentration of osmogen sodium chloride (OM-SC) and potassium chloride (OM-KC) were further enteric-coated. These also were found to be useful in providing a sustained delivery of nearly 80–90% of the drug into the colonic region. The coat weight required in these tablets for protection in the upper gastrointestinal conditions varied from 9.69% in OM-KC tablets to 4.65% in OM-SC tablets.

Celecoxib

Pulsatile flow

Targeted drug delivery

10.1080/10717540500309180

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Influence of operational variables on properties of piroxicam pellets prepared by extrusion-spheronization: A technical note

AAPS PharmSciTech (2007)

Vivek Ranjan Sinha Manoj K. Agrawal Rachna Kumria Jayant R. Bhinge

Friability

Pellet

10.1208/pt0801020

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Evaluation of mucoadhesive properties of chitosan microspheres prepared by different methods

AAPS PharmSciTech (2004)

Sanju Dhawan Anil Kumar Singla Vivek Ranjan Sinha

Zeta potential

Glutaraldehyde

Mucoadhesion

10.1208/pt050467

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Citations (201)

Chitosan-Based Nanocarriers

CRC Press eBooks (2018)

Sumit Sharma Vivek Ranjan Sinha Amita Sarwal Rahul Shukla

Chitin is one of the most widely present polysaccharidesacross the world.Mainly obtained from crabs and crustaceans, chitosan is obtained on subsequent deacetylation of chitin. Herein, we are reviewing the potential of chitosan as a nanocarrier for delivery of bioactives, for example, anticancer and gene molecules. Utility of chitosan at local sites with reference to its mucoadhesion, plausible chemical modifications, and its processing for selected applications are also discussed. This chapter also endeavors to touch upon the applications of chitosan in colon, nasal, dental and ocular drug delivery, with special emphasis on nanotechnology-based delivery of bioactives.Various studies have also been elaborated on value-added chemical modifications to alter the properties of chitosan, for example, solubility. Nevertheless, the highly recognized characteristics of chitosan (biocompatibility and biodegradability) broaden its realm in wide-ranging biomedical applications of this polysaccharide, particularly using nanotechnology.

Nanocarriers

10.1201/9781351139281-13

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Volume 22 Indices

Critical Reviews in Therapeutic Drug Carrier Systems (2005)

Jeff Rey Thomas L. Ellis Deborah Kilpatrick Paul Consigny Santosh Prabhu

10.1615/critrevtherdrugcarriersyst.v22.i6.30

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