Synovial sarcoma (SS), a malignant and uncommon soft tissue sarcoma, typically manifests in the extremities and trunk. However, its occurrence in the infratemporal fossa (ITF) of the head and neck is exceedingly rare. Patients afflicted with SS in this anatomical region pose considerable challenges, as radical surgery is often difficult to undertake, leading to a high rate of postoperative recurrence. Moreover, it is often difficult to effectively control the tumor when the cancer relapses. Much of our understanding regarding SS of ITF stems from limited case reports, with a lack of established clinical guidelines for its management. There exists a significant clinical need for effective therapeutic approaches.
Vulvar carcinoma exhibits a robust correlation alongside HPV infection; however, the impact of HPV rank on the prognostic outcomes of radiation therapy within vulvar malignancies stays ambiguous. In the present study, we performed a comprehensive examination as well as meta-analysis to assess the influence of infection with HPV upon the long-term outlook as well as sensitivity of individuals with vulvar cancer undergoing radiation therapy.
// Chao Li 1, 2, * , Yinju Zhu 3, * , Tong Tong 2, 4 , Ye Xu 2, 5 , Yun Guan 1, 2 , Jingwen Wang 1, 2 , Huankun Wang 3 and Ji Zhu 1, 2 1 Department of Radiation Oncology, Fudan University Shanghai Cancer Center, Shanghai, China 2 Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China 3 Department of Radiation Oncology, Dalian Third People’s Hospital Affiliated to Dalian Medical University (Dalian Cancer Hospital), Dalian, China 4 Department of Radiology, Fudan University Shanghai Cancer Center, Shanghai, China 5 Department of Colorectal Surgery, Fudan University Shanghai Cancer Center, Shanghai, China * These authors have contributed equally to this work Correspondence to: Ji Zhu, email: leoon.zhu@gmail.com Huankun Wang, email: 0411whk@163.com Keywords: pelvic recurrence; advanced rectal cancer; radiotherapy; total mesorectal excision; radiation toxicity Abbreviations: Multi-disciplinary treatment (MDT); Radiotherapy (RT); Total mesorectal excision (TME); Clinical target volume (CTV); Lateral lymph node (LLN) Received: June 24, 2017 Accepted: August 17, 2017 Published: October 07, 2017 ABSTRACT Background: To analyze the local distribution of pelvic recurrence after total mesorectal excision, with a view to simplifying the formulation of optimal individualized radiotherapy plans. Methods: We retrospectively investigated the data of 168 patients diagnosed with recurrent pelvic cancer treated at Fudan University Shanghai Cancer Center between January 2008 and December 2012. The following were collected depending on availability: operative report, histological report, specimen photographs, initial preoperative images, images confirming local recurrence, and clinical history. Results: A total of 203 lesions of local recurrence were identified. The most common sites of pelvic recurrence were the mesorectum, including the anastomotic stoma in 53.0% of cases; presacral space in 27.4%, and pelvic floor and perineum in 21.4% the cases. Recurrence was most common in the lower pelvic region (i.e., below the upper border of the acetabulum), accounting for approximately 76.2% (128 cases) of cases. In patients with mid-rectal and distal rectal carcinoma, <5% had relapse in the upper pelvis, and in those with distal rectal cancer, no recurrence occurred in the external iliac and inguinal area. Conclusions: Patients with pelvic cancer may benefit by individualized treatment plans aimed at achieving a balance between tumor control and minimal risk of irradiation-induced toxicity.
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