Nima Babhadi‐Ashar

Tehran University of Medical Sciences

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Mitra‐Sadat Sadat‐Shirazi

Tehran University of Medical Sciences

Mohammad‐Reza Zarrindast

Tehran University of Medical Sciences

Farin Kamangar

Morgan State University

Kazem Zendehdel

Tehran University of Medical Sciences

Maryam Hadji

Tampere University

Afarin Rahimi‐Movaghar

Tehran University of Medical Sciences

Hossein Khavari-Daneshvar

Tehran University of Medical Sciences

Abdolvahab Moradi

Golestan University

Solmaz Khalifeh

Islamic Azad University Medical Branch of Tehran

Reza Malekzadeh

Tehran University of Medical Sciences

Cooperative Institutions

Tehran University of Medical Sciences

University of Tehran

Shariati Hospital

Bushehr University of Medical Sciences

Islamic Azad University Medical Branch of Tehran

Motamed Cancer Institute

Shahid Beheshti University of Medical Sciences

Shiraz University of Medical Sciences

Stem Cell Technology Research Center

Golestan University of Medical Sciences

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A Report of Transplantation of 224 Patients with Beta Thalassemia Major in Tehran, 1991– 2004.

Blood (2004)

Ardeshir Ghavamzadeh Mohamad Jahani Kamran Alimoghaddam Masoud Iravani Babak Bahar

Beta thalassemia

Regimen

10.1182/blood.v104.11.3772.3772

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Citations (0)

Morphine exposure before conception affects anxiety-like behavior and CRF level (in the CSF and plasma) in the adult male offspring

Brain Research Bulletin (2018)

Saba Sabzevari Kiyana Rohbani Mitra‐Sadat Sadat‐Shirazi Nima Babhadi‐Ashar Atena Shakeri

Elevated plus maze

10.1016/j.brainresbull.2018.11.022

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Citations (27)

Sensitivity of self-reported opioid use in case-control studies: Healthy individuals versus hospitalized patients

PLoS ONE (2017)

Hamideh Rashidian Maryam Hadji Maryam Marzban Mahin Gholipour Afarin Rahimi‐Movaghar

Background Several case-control studies have shown associations between the risk of different cancers and self-reported opium use. Inquiring into relatively sensitive issues, such as the history of drug use, is usually prone to information bias. However, in order to justify the findings of these types of studies, we have to quantify the level of such a negative bias. In current study, we aimed to evaluate sensitivity of self-reported opioid use and suggest suitable types of control groups for case-control studies on opioid use and the risk of cancer. Methods In order to compare the validity of the self-reported opioid use, we cross-validated the response of two groups of subjects 1) 178 hospitalized patients and 2) 186 healthy individuals with the results of their tests using urine rapid drug screen (URDS) and thin layer chromatography (TLC). The questioners were asked by trained interviewers to maximize the validity of responses; healthy individuals were selected from the companions of patients in hospitals. Results Self-reported regular opioid use was 36.5% in hospitalized patients 19.3% in healthy individuals (p-value> 0.001).The reported frequencies of opioid use in the past 72 hours were 21.4% and 11.8% in hospitalized patients and healthy individuals respectively. Comparing their responses with the results of urine tests showed a sensitivity of 77% and 69% among hospitalized patients and healthy individuals for self-reports (p-value = 0.4). Having corrected based on the mentioned sensitivities; the frequency of opioid regular use was 47% and 28% in hospitalized patients and healthy individuals, respectively. Regular opioid use among hospitalized patients was significantly higher than in healthy individuals (p-value> 0.001). Conclusion Our findings showed that the level of opioid use under-reporting in hospitalized patients and healthy individuals was considerable but comparable. In addition, the frequency of regular opioid use among hospitalized patients was significantly higher than that in the general population. Altogether, it seems that, without corrections for these differences and biases, the results of many studies including case-control studies on opioid use might distort findings substantially.

10.1371/journal.pone.0183017

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Citations (48)

Evaluation of dynorphin and kappa-opioid receptor level in the human blood lymphocytes and plasma: Possible role as a biomarker in severe opioid use disorder

Drug and Alcohol Dependence (2019)

Kourosh Shahkarami Nasim Vousooghi Fereshteh Golab Azam Mohsenzadeh Parastoo Baharvand

Dynorphin

κ-opioid receptor

10.1016/j.drugalcdep.2019.107638

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Tramadol induces changes in Δ-FosB, µ-opioid receptor, and p-CREB level in the nucleus accumbens and prefrontal cortex of male Wistar rat

The American Journal of Drug and Alcohol Abuse (2019)

Mitra‐Sadat Sadat‐Shirazi Nima Babhadi‐Ashar Solmaz Khalifeh Sarah Mahboubi Hamid Ahmadian-Moghaddam

Background: Besides the analgesic effect of tramadol, prolonged exposure to tramadol can induce adaptive changes thereby leading to dependence and tolerance. Tramadol induces its effect via µ-opioid receptor (MOR). However, tramadol has other targets such as serotonin and epinephrine transporters.Objective: CREB and ΔFosB are transcriptional factors, which are involved in the behavioral abnormalities underlying drug abuse. In this study, the effects of acute and chronic tramadol treatments on MOR, ΔFosB, and CREB levels were studied.Methods: For this purpose, 36 male Wistar rats were used. The animals were divided into two main groups. A total of 18 animals received tramadol (0, 5, and 10 mg/kg) acutely and 18 animals received the same doses for the following 14 days. One hour after the last injection, the NAC and PFC were dissected and kept at −80°C in liquid nitrogen. Using western blotting technique, the levels of MOR, ΔFosB, and p-CREB were evaluated.Results: In the NAC, acute tramadol exposure increases the levels of MOR and p-CREB. Moreover, chronic tramadol administration in this region results in elevated levels of MOR, ΔFosB and p-CREB compared with saline-treated rats. The levels of MOR and p-CREB in the PFC increased in both acute and chronic tramadol exposure. Also, ΔFosB levels increased only following chronic tramadol administration. The results revealed that adaptive changes occurred during drug exposure.Conclusion: We concluded that both CREB and ΔFosB played a role in tramadol dependence. Additionally, increased MOR levels during tramadol treatments might be due to receptor desensitization.

FOSB

μ-opioid receptor

10.1080/00952990.2018.1529182

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Citations (7)

Executive functions are related to serum testosterone and basal metabolism rate fluctuation but not lymphocyte dopamine receptor expression in the young healthy participants

Physiology and Pharmacology (2018)

Mitra‐Sadat Sadat‐Shirazi Ghorbangol Ashabi Nima Babhadi‐Ashar Mohammadreza Bahrami Hessari Nasim Vousooghi

Introduction Herein, we evaluated linkages between EFs performances and dopamine receptor (DR) mRNA and testosterone level in the young Iranian male people.Methods All 140 participants were normalized using depression, anxiety and stress scale questionnaire. Remained 108 volunteers were tested against drug abuse and then volunteers were distinguished by Wisconsin Card Sorting Test (WSCT). According to WCST, participants were divided into two low and high EFs performance. Afterward, anthropometric factors, body mass index (BMI) and serum testosterone level were measured in low and high EFs groups. Blood samples were collected, and biochemical and anthropometric data were evaluated; serum testosterone and DR mRNA expression were assessed in participants.Results Data showed there are no differences between two groups in Na, K, glucose, urea, creatinine, SGPT, SGOT and other biochemical serum agents (P>0.05) but BMI was increased in low EFs compared with high EFs (P=0.000). Interestingly, there is no difference in DR expression between two groups (P>0.05).Conclusion Our data presented that fluctuation of EFs performances in healthy adult male cases might depend on BMI and serum testosterone; while dopamine receptors in the blood lymphocytes had no substantial role in the EFs. High serum testosterone reduced EFs in the young adults.

Basal (medicine)

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Correction: Sensitivity of self-reported opioid use in case-control studies: Healthy individuals versus hospitalized patients

PLoS ONE (2018)

Hamideh Rashidian Maryam Hadji Maryam Marzban Mahin Gholipour Afarin Rahimi‐Movaghar

[This corrects the article DOI: 10.1371/journal.pone.0183017.].

Correct name

10.1371/journal.pone.0192814

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Citations (2)

Correction: Sensitivity of self-reported opioid use in case-control studies: Healthy individuals versus hospitalized patients

PLoS ONE (2021)

Hamideh Rashidian Maryam Hadji Maryam Marzban Mahin Gholipour Afarin Rahimi‐Movaghar

Correct name

10.1371/journal.pone.0257180

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Effervescent tablet‐assisted demulsified dispersive liquid–liquid microextraction based on solidification of floating organic droplet for determination of methadone in water and biological samples prior to GC‐flame ionization and GC‐MS

Journal of Separation Science (2020)

Masoomeh Jafarinejad Maryam Ezoddin Navid Lamei Khosrou Abdi Nima Babhadi‐Ashar

Abstract A novel effervescent tablet‐assisted demulsified dispersive liquid–liquid microextraction based on the solidification of floating organic droplet was developed to determine methadone prior to gas chromatography with flame ionization detection and gas chromatography with mass spectrometry. In this method, a tablet composed of citric acid, sodium carbonate, and 1‐undecanol was utilized. The resulting effervescent tablet generated carbon dioxide in situ to disperse 1‐undecanol in the sample. Thus, the dispersive and extraction processes were performed in one synchronous step. An aliquot of acetonitrile as the demulsifier solvent was used for the separation of two phases instead of centrifugation. Under optimal conditions, the developed method was linear up to 50 000 µg/L with correlation coefficients higher than 0.99. Moreover, limits of detection and limits of the quantification were in the range of 3‐10 and 7‐30 µg/L in water and biological samples, respectively. Intra‐ and interday precisions (n = 6) of the spiked methadone at a concentration level of 50 µg/L were over ranges of 5.1‐6.8% and 5.7‐7.1%, respectively. The preconcentration factors and recovery values were obtained in the range of 140‐145 and 98.1 to 101.6% in real samples, respectively.

Flame ionization detector

Sample Preparation

10.1002/jssc.202000078

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Citations (24)

Correlation between Cigarette Smoking and Urine Cotinine Level in Gastric Cancer Patients.

PubMed (2014)

Nima Babhadi‐Ashar Masoud Sotoudeh Ebrahim Azizi Jafar Bashiri Reza Didevar

Various substances in cigarette smoke including nicotine have been shown to promote/induce cancer cell proliferation. Since cotinine has a longer half life and stability in the blood, it has become the preferred biomarker for cigarette smoking exposure. Seventy-three gastric cancer patients were included in this study. The tumor tissues were stained with H & E for pathological evaluation. The cotinine levels were measured in urine using a competitive ELISA. Tumors were 90% adenocarcinoma with 63% intestinal and 37% diffuse subtypes. Tumors were poorly (45.2%) or moderately differentiated (41.1%) and localized mainly (77%) in the upper part of stomach. The levels of cotinine were significantly different between smoker (283.83 ± 178.10 ng/mL) and non-smoker (39.28 ± 113.34 ng/mL) groups (p < 0.001). However, there is no-significant correlation between tumor characteristics and cotinine level in smoker patients. Cotinine level correlates with smoking in gastric patients, however, correlation with the tumor features has not been observed.

Cotinine

Stomach cancer

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