Li-hua Ma

82th Hospital of Pla

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i-10 index

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Luning Wang

Chinese PLA General Hospital

Jiping Tan

Chinese PLA General Hospital

Nan Li

Peking University Third Hospital

Tian-Xi Wu

Kunming University

Jie He

Center for Excellence in Brain Science and Intelligence Technology

Cai-cai Bao

Xie Zheng-jun

Zunyi Medical University

Juan Hui

Beijing Hospital

Nan Liu

Qingdao University

Shige Qi

National Center for Chronic and Noncommunicable Disease Control and Prevention

Cooperative Institutions

Chinese Academy of Medical Sciences & Peking Union Medical College

Beijing Hospital

Peking Union Medical College Hospital

Peking University

Chinese People's Liberation Army

Southern Medical University

Chinese Academy of Sciences

Kunming General Hospital of Chengdu Military Command

Beijing Geriatric Hospital

Sun Yat-sen University

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The etiological effect of a new low-frequency ESR1 variant on Mild Cognitive Impairment and Alzheimer’s Disease: a population-based study

Aging (2018)

Xiaoling Li Xiaoquan Zhu Wandong Zhang Fan Yang Juan Hui

Latent genetic variations of cholesterol metabolism-related genes in late-onsetAlzheimer's disease, especially, as well as in mild cognitive impairment pathogenesis are still to be studied extensively.Thus, we performed the targeted-sequencing of 12 nuclear receptor genes plus APOE which were involved in cholesterol content modulation to screen susceptible genetic variants and focused on a new risk variant ESR1 rs9340803 at 6q25.1 for both late-onset Alzheimer's disease (OR=3.30[1.84~4.22],p<0.001) and mild cognitive impairment (OR=3.08[1.75~3.89],p<0.001).This low-frequency variant was validated in three independent cohorts totaling 854 late-onset Alzheimer's disease cases, 1059 mild cognitive impairment cases and 1254 controls from nine provinces of China mainland.Preliminary functional study on it revealed decreased ESR1 expression in vitro.Besides, we detected higher serum Aβ1-40 concentration in participants carrying this variant (p=0.038) and lower plasma total cholesterol level in this variant carriers with late-onset Alzheimer's disease (p=0.009).In summary, we identified a susceptible variant which might contribute to developing mild cognitive impairment at earlier stage and Alzheimer's Disease later.Our study would provide new insight into the disease causation of late-onset Alzheimer's disease and could be exploited therapeutically.

Apolipoprotein E

Cognitive Decline

Etiology

10.18632/aging.101548

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Citations (12)

Advances in the study of the relationship between optic neuromyelitis and clostridium perfringens

Jiefangjun yixue zazhi (2019)

Fei Qi Qinfang Xie Li-hua Ma Cai-cai Bao Yan-xia Niu

Neuromyelitis optica is an autoimmune astrocytopathy of the central nervous system mainly characterized by recurrent episodes of optic neuritis and acute transverse myelitis. Although the exact etiology and pathogenesis of NMO remain to be established, complex interactions between genetic and environmental factors are thought to be involved in its development. Studies have shown that the pathogenesis of NMO is closely related to gut microbiome, and the content of clostridium perfringens in gut microbiome of NMO patients was significantly increased. This article mainly reviews the correlation between the neuromyelitis optica and clostridium perfringens, in order to further clarify the pathogenesis of NMO and provide reference for clinical treatment. DOI: 10.11855/j.issn.0577-7402.2019.05.12

Clostridium perfringens

Neuromyelitis Optica

Pathogenesis

Optic neuritis

Etiology

Gut microbiome

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Using The Simple Of Verhulst Budget The Future Population Of Xun Hua County

Journal of Qinghai Junior Teachers' College (2004)

Li-hua Ma

Using the simple of verhulst budget the development trend of population of Xun Hua county, and analyze the reason which increase quickly of population in Xun Hua after liberation.

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Intraperitoneal Injection of Multiplacentas Pooled Cells Treatment on a Mouse Model with Aplastic Anemia

Stem Cells International (2016)

Jun LiHong Chen Yan-Bo Lv Qiang Wang Xie Zheng-jun

Coinfusion of hematopoietic and mesenchymal stem cells is more effective than hematopoietic stem cell transplantation alone. It is necessary to explore a safe and routine mixed stem cell intraperitoneal transplantation method. Multiplacentas pooled cells were intraperitoneally injected into a radiation- and immunity-induced mouse aplastic anemia model with single time. Then, mouse survival time, peripheral blood hemoglobin count, bone marrow architecture, and donor cell engraftment were assessed. The recipient mouse exhibited donor cell engraftment in both bone marrow and peripheral blood. Survival time and peripheral blood hemoglobin count increased in placenta pooled cells treated mice, compared with model-only controls (P = 0.048 and P = 0.000, resp.). However, placentas pooled cells failed to cause a significant decrease in bone marrow pimelosis area (P = 0.357). Intraperitoneally transplanted multiplacentas pooled cells can survive and engraft into a host body through blood circulation, which can increase the life span of an aplastic anemia model mice, and delay but not abrogate the development of aplastic anemia. Furthermore, they appear to play a role in increasing peripheral blood hemoglobin level response for increasing the life span of aplastic anemia model mice.

Aplastic anemia

Hematopoietic stem cell

10.1155/2016/3279793

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Citations (14)

Characteristics of participants’ and caregivers’ influence on non-response in a cross-sectional study of dementia in an older population

Archives of Gerontology and Geriatrics (2015)

Jiping Tan Nan Li Bo Cui Luning Wang Yiming Zhao

Cross-sectional study

10.1016/j.archger.2015.08.018

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Citations (10)