Yu. S. Absatarova

Endocrinology Research Center

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ЕН

Е. Н. Андреева

Ministry of Health of the Russian Federation

O. R. Grigoryan

Ministry of Health of the Russian Federation

E. V. Sheremetyeva

Endocrinology Research Center

РК

Р. К. Михеев

Ministry of Health of the Russian Federation

Yu. S. Evseeva

Endocrinology Research Center

ГА

Г. А. Мельниченко

Endocrinology Research Center

ИИ

И. И. Дедов

Endocrinology Research Center

НГ

Н. Г. Мокрышева

Endocrinology Research Center

L.V. Adamyan

National Medical Research Center for Obstetrics, Gynecology and Perinatology named after Academician V.I.Kulakov of the Ministry of Healthcare of the Russian Federation

A. N. Kurinova

Endocrinology Research Center

Cooperative Institutions

Endocrinology Research Center

Ministry of Health of the Russian Federation

Sechenov University

Russian Academy of Sciences

Moscow State University of Medicine and Dentistry

National Medical Research Center for Obstetrics, Gynecology and Perinatology named after Academician V.I.Kulakov of the Ministry of Healthcare of the Russian Federation

Faculdades Guarulhos

Academy of Medical Sciences

National Medical Research Center of Cardiology

Federal Research Centre of Nutrition and Biotechnology

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Molecular and cellular mechanisms of ageing: modern knowledge (literature review)

Problems of Endocrinology (2023)

Р. К. Михеев Е. Н. Андреева O. R. Grigoryan E. V. Sheremetyeva Yu. S. Absatarova

Ageing (as known as eldering, senescence) is a genetically and epigenetically programmed pathophysiological process. Velocity of biological ageing is defined as balance between alteration and reparation of body structures. According to last World Health Organization (WHO) highlights ageing still stays an extremely actual scientific, social and demographic problem: in 2020 total number of people older than 60 years and older was 1 billion people; in 2030 future number may be 1,4 billion people, in 2050 — 2,1 billion people. Absence of single universal theory of aging nowadays is reason for scientifical and clinical collaboration between biologists and doctors, including endocrinologists. Designing of potentially effective newest anti-ageing strategies (such as natural/synthetic telomerase regulators, mesenchymal stem cells etc.) is of interest to scientific community. The aim of present article is a review of modern omics (genomic, proteomic, metabolomic) ageing mechanisms, potential ways of targeted prevention and treatment of age-related disease according to conception of personalized medicine. Present review is narrative, it does not lead to systematic review, meta-analysis and does not aim to commercial advertisement. Review has been provided via PubMed article that have been published since 1979 until 2022.

Narrative review

Cellular senescence

Ageing society

10.14341/probl13278

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Citations (4)

Analysis of melatonin concentration and its correlation with ovarian disfunction among obese women of reproductive age

Problems of Endocrinology (2021)

Р. К. Михеев Е. Н. Андреева E. V. Sheremetyeva Yu. S. Absatarova Т. А. Пономарева

One of the new directions in the study of reproductive disorders in obese women is the effect and receptor sensitivity of melatonin on the gonadotropic function of the pituitary gland and ovariogenesis, taking into account the chronology of «light pollution». At the present stage, there is very little literature on the influence of the aspects of «light pollution» on the problem of obesity and reproductive disorders in the literature. This review is an attempt to combine the above problem in terms of the impact of «light pollution» and the level of receptor sensitivity of melatonin in women of reproductive age with obesity. The literature search was carried out in Russian (eLibrary, CyberLeninka.ru) and international (PubMed, Cochrane Library) databases in Russian and English. Free access to the full text of the articles was a priority. The selection of sources was prioritized for the period from 2015 to 2019. However, given the insufficient knowledge of the chosen topic, the choice of sources was dated from 1992. The work was carried out as part of the study «Central and peripheral pathophysiological mechanisms of development of adipose tissue diseases, taking into account clinical and hormonal characteristics» 2020–2022.

Reproductive system

10.14341/probl12710

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Citations (1)

Melatonin status disorders in gynecological practice: pathogenetic aspects and therapeutic possibilities

Russian Bulletin of Obstetrician-Gynecologist (2022)

Е. Н. Андреева Yu. S. Absatarova

Репродуктивная функция находится под влиянием множества регуляторов, одним из которых является мелатонин. Знания о функциональной активности этого гормона в последние годы были значительно расширены. Так, известно, что он выполняет не только циркадианный контроль, но и обладает мощными антиоксидантными свойствами. Это имеет решающее значение в процессе фолликулогенеза и непосредственно в овуляции. Нарушения мелатонинового обмена рассматривают как одно из звеньев патогенеза таких заболеваний, как синдром поликистозных яичников, эндометриоз, ожирение, преждевременная недостаточность яичников и бесплодие. В статье представлен обзор литературы с разбором патогенетических механизмов и возможностей применения аналогов эндогенного мелатонина в гинекологической практике.

10.17116/rosakush20222206148

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Citations (1)

Melatonin in human reproduction

Russian Journal of Human Reproduction (2016)

Yu. S. Absatarova Andreeva En E. V. Sheremetyeva O. R. Grigoryan

Human reproduction

10.17116/repro20162218-11

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Citations (3)

Neuroendocrine features of the pathogenesis of polycystic ovary syndrome (literature review)

Problems of Endocrinology (2023)

Yu. S. Absatarova Yu. S. Evseeva Е. Н. Андреева

Polycystic ovary syndrome (PCOS) is one of the most pressing problems in endocrine gynecology. The main signs of the disease are hyperandrogenism, menstrual and/or ovulatory dysfunction, and polycystic ovarian structure according to ultrasound. Women with PCOS are at risk for developing metabolic syndrome, type 2 diabetes, cardiovascular disease, and endometrial cancer. In this connection, the pathogenetic mechanisms of the occurrence of this syndrome are continuously studied and new methods of treatment are being sought. PCOS is characterized by a wide range of various disorders of the neuroendocrine regulation of the reproductive system. The main focus of the review is aimed at summarizing information about the etiological role of neuropeptides and neurotransmitters, such as phoenixin, galanins, orexins, GABA, in the pathophysiology of PCOS and about the possibility of their use for diagnostic and therapeutic purposes. In recent decades, the interest of scientists has been focused on the study of KNDy neurons, because it is the kisspeptin synthesized by them that is one of the main regulators of the hypothalamic-pituitary-ovarian axis. This article discusses data on the significance of KNDy neurons in the pathogenesis of the syndrome. Information is provided on the effect of elevated levels of androgens and anti-Müllerian hormone on GnRH neurons. Also analyzed are studies on functional and structural disorders in the hypothalamus in PCOS. Literature search was carried out in national (eLibrary, CyberLeninka.ru) and international (PubMed, Cochrane Library) databases in Russian and English. The priority was free access to the full text of articles. The choice of sources was prioritized for the period from 2018 to 2023.However, taking into account the insufficient knowledge of the chosen topic, the choice of sources dates back to 1998.

Hyperandrogenism

Kisspeptin

Neurokinin B

Etiology

10.14341/probl13350

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Citations (2)

The efficacy of 17b-estradiol and low dosed drospirenone use in postmenopausal women (literature review)

GYNECOLOGY (2015)

Е. Н. Андреева O. R. Grigoryan Yu. S. Absatarova

Vasomotor symptoms, including hot flushes (HF), are the most common symptoms of menopause, requiring treatment with estrogen and/or progestogen. Recent international guidelines recognize the need to use the lowest effective dose of hormone replacement therapy. Drospirenone (DR) in combination with 17-estradiol (E) is used as hormone therapy (HT) for relief the symptoms and prevention of postmenopausal osteoporosis.The aim of this review is a meta-analysis of studies examining the efficacy and safety of low-dose DR and E for the treatment of vasomotor symptoms inpostmenopausal women.The review presents data of 2 large randomized controlled studies that evaluated the lowest effective dose combination DR/E, the safety of this dose for endometrium, identified features of its pharmacodynamics and pharmacokinetics, depending on various factors.In the first, a study of the lowest effective doses of DR/E for the treatment of HF in postmenopausal women was made. It led to the conclusion that the com-bination of DR 0,25 mg/E of 0,5 mg is the minimum effective dose. Efficacy of low doses of DR/E correlated with exposure DR and E in serum, while smoking had a negative impact on the Efficacy of treatment.Another study assessed the risk of endometrial hyperplasia and bleeding pattern in patients receiving 0,25 mg DR/E of 0,5 mg for 12 months. At the end of the study no evaluable women in the DR/E2 group had an endometrial biopsy result of hyperplasia or worse, which endometrial confirmed the safety of receiving DR 0,25 mg/E of 0,5 mg.Thus, the minimum effective dose for the relief of HF without causing any significant impact on the endometrium is DR of 0,25 mg/E of 0,5 mg. According to the results of the pharmacokinetic study a correlation between effectiveness of low dose DR/E with DR and E exposure levels was showed, and smoking reduces the effectiveness of hormonal therapy. This drug not only copes with moderate to severe hot flashes, but also reduces the incidence of symptoms of vulvovaginal atrophy, improving quality of life.

Drospirenone

Progestogen

Endometrial hyperplasia

Vasomotor

Hormone Therapy

Tibolone

10.26442/2079-5831_17.1.34-40

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Citations (2)

Therapeutic possibilities in the correction of vegetative disorders and anovulation in case of premature ovarian insufficiency

Russian Bulletin of Obstetrician-Gynecologist (2019)

Е. Н. Андреева Yu. S. Absatarova

Premature ovarian insufficiency

Anovulation

Premature ovarian failure

10.17116/rosakush20191905161

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Citations (2)

The dual role of the menopausal hormonal therapy as the enhancer of pleiotropic telomere rejuvenation and the silencer of cellular aging (literature review)

Problems of Endocrinology (2022)

O. R. Grigoryan T. M. Frolova Р. К. Михеев E. V. Sheremetyeva Yu. S. Absatarova

Present worldwide healthcare researches prove that female patients are more sensitive to the population aging. Menopause or climacteria (climax) — is not as ageing itself, but a physiological unstoppable process. The main task for a physician is to improve life quality for female despite of ageing problems. Menopausal hormone therapy (MHT) due to the estrogen component has an anti-inflammatory, antioxidant effect and promotes the expression of telomerase, which together changes the homeostasis and integrity of telomeres. The use of MHT for five years or more can not only significantly change the quality of life, but also increase its duration. Literature search was carried out in national (eLibrary, CyberLeninka.ru) and international (PubMed, Cochrane Library) databases in Russian and English. The priority was free access to the full text of articles. The choice of sources was prioritized for the period from 2019 to 2021. However, taking into account the insufficient knowledge of the chosen topic, the choice of sources dates back to 1989.

Rejuvenation

Silencer

10.14341/probl12895

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Citations (1)

Modern aspects of polycystic ovary syndrome in patients with type 1 diabetes (a review)

Russian Journal of Human Reproduction (2015)

O. R. Grigoryan Yu. S. Absatarova Е. Н. Андреева Г. А. Мельниченко И. И. Дедов

10.17116/repro201521227-30

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Citations (1)

Differential specificities of placental pathologies and uteroplacental malperfusion in types 1 and 2 diabetes mellitus and gestational diabetes

Voprosy ginekologii akušerstva i perinatologii (2020)

O. R. Grigoryan Л. И. Ибрагимова E. I. Degtyareva Yu. S. Absatarova Р. К. Михеев

10.20953/1726-1678-2020-1-77-82

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Citations (1)