M. Brufani

Abstract UV.‐, IR.‐ and NMR.‐spectra of the antibiotic granaticin and several of its derivatives and degradation products are discussed. The spectroscopic properties agree with the formula XX for the antibiotic, which was fully elucidated by an X‐ray structural analysis (see following communication).

10.1002/hlca.19680510609

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Citations (55)

Stoffwechselprodukte von Mikroorganismen. 67. Mitteilung [1]. Die Struktur des Granaticins und des Granaticins B. 2. Teil: Die Kristallstruktur des Tri‐O‐acetyl‐O‐jodacetyl‐granaticins

Helvetica Chimica Acta (1968)

M. Brufani Markus Dobler

Abstract The crystal structure of tri‐O‐acetyl‐O‐iodoacetyl‐granaticin has been determined by X‐ray analysis of threedimensional diffractometer intensity data. The crystals are orthorhombic, a = 17.85, b = 14.90, c = 11.26 Å, Z = 4, space group P 2 1 2 1 2 1 . The molecular structure was established by the heavy atom method and refined by full‐matrix least‐squares analysis. The molecular constitution and configuration is given by formula II. The chirality was determined by the use of anomalous dispersion effects.

Orthorhombic crystal system

Diffractometer

10.1002/hlca.19680510610

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Citations (30)

New analogs of physostigmine: Alternative drugs for Alzheimer's disease?

Life Sciences (1988)

Maurizio Marta Claudio Castellano A. Oliverio Flaminia Pavone P.G. Pagella

Physostigmine

10.1016/s0024-3205(88)80010-9

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Citations (40)

Rifamycins as inhibitors of retroviral reverse transcriptase from M-MuLV, RAV-2, and HIV-1.

PubMed (1992)

Cecilia Bartolucci Luciano Cellai Patrizia Di Filippo Anna Laura Segre M. Brufani

Reverse-transcriptase inhibitor

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ChemInform Abstract: 4‐Deoxypyrido[1′,2′:1,2]imidazo[5,4‐;c]rifamycin SV Derivatives. A New Series of Semisynthetic Rifamycins with High Antibacterial Activity and Low Gastroenteric Absorption.

Chemischer Informationsdienst (1985)

Egidio Marchi L. Montecchi Arianna Venturini Giuseppe Mascellani M. Brufani

Abstract Die Verbindungen (I), deren Synthese beschrieben wird, sind antibakteriell hochwirksam.

Rifamycin

10.1002/chin.198544331

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A comparison of inhibitory effect of MF-201 and THA on RAT brain cholinesterase

Pharmacological Research Communications (1988)

P.G. Pagella Pierluigi Rugarli Marco Munari Rodolfo Bernardi M. Pomponi

Fisher information

Density matrix

10.1016/s0031-6989(88)80412-0

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Citations (1)

Synthesis and pharmacological evaluation of new compounds with a potential action on the adrenergic system.

PubMed (1982)

Merli William Melloni Tamagnone Gf Giuseppe Mascellani G. Andriuoli

A series of compounds with a potential activity on both alpha and beta-adrenoreceptors were synthesized and evaluated with in vitro and in vivo tests. Aryloxypropanolamino derivatives N-substituted with alpha 2-benzodioxanylmethyl group showed a favourable alpha/beta ratio and a high selectivity towards beta 1 receptors. Substitution with different aralkyl groups afforded compounds with a low alpha-activity, although with a high potency and selectivity towards beta 1 receptors. The results are discussed on the basis of the working hypothesis and compared with those obtained for reference compounds.

BETA (programming language)

Alpha (finance)

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Citations (1)

Papers

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