Junren Zhang

Nanjing University of Science and Technology

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Zuliang Liu

Nanjing University of Science and Technology

Jiang Shan-xiang

Bio-Medical Science (South Korea)

Qizheng Yao

China Pharmaceutical University

Yi Wu

Shandong University of Traditional Chinese Medicine

Shengli Chen

Shandong Provincial Institute of Dermatology and Venereology

Zhao Tianen

Shandong Provincial Institute of Dermatology and Venereology

Jun Yan

Fujian Medical University

Lingtong Quan

Nanjing Agricultural University

Changsheng Li

Beijing Institute of Technology

Cooperative Institutions

Nanjing Agricultural University

Nanjing University of Science and Technology

Shandong Provincial Institute of Dermatology and Venereology

Chongqing University

China Pharmaceutical University

Nanjing Library

Bio-Medical Science (South Korea)

Shandong University of Traditional Chinese Medicine

Yunnan Agricultural University

Civil Aviation Flight University of China

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A Novel Synthesis of the Efficient Anti-Coccidial Drug Halofuginone Hydrobromide

Molecules (2017)

Junren Zhang Qizheng Yao Zuliang Liu

Background: Halofuginone hydrobromide (1) is recognized as an effective drug against several species of Eimeria (E.) in poultry. In this paper, we describe a convenient and low cost preparation method for the compound, as well as primary validation of its activity. Methods: First, 7-bromo-6-chloroquinazolin-4(3H)-one (2) was prepared from m-chlorotoluene by a conventional process, and then chloroacetone was creatively introduced in two steps. Finally, halofuginone hydrobromide (1) was obtained from 7-bromo-6-chloro-3-(3-cholroacetonyl) quinazolin-4(3H)-one (4) by a four-step reaction sequence including condensation, cyclization, deprotection and isomerization. The structures of the relative intermediates and target compound were characterized by melting point, IR, MS and ¹H-NMR. Besides, the protective effect of compound 1-supplemented chicken diet at doses of 6, 3 and 1.5 mg per 1 kg were evaluated on chickens infected with E. tenella, by reduction in mortality, weight loss, fecal oocyst excretion and gut pathology, respectively. Results: Halofuginone hydrobromide (1) was prepared successfully by and improved and innovative method based on traditional research. Moreover, the synthesized halofuginone hydrobromide significantly exhibited an anti-coccidial property. Conclusions: The fruitful work described in this Communication has resulted in halofuginone hydrobromide, which has a good pharmaceutical development prospects, becoming more available for large-scale production.

Hydrobromide

10.3390/molecules22071086

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One Novel 2-(2-Phenylethyl)Chromone Glycoside from Aquilaria sinensis

Chemistry of Natural Compounds (2017)

Lingtong Quan Junren Zhang Yi Wu

Chromone

10.1007/s10600-017-2078-0

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Preparation of solid hydrogen peroxide and research of germicidal test

Nanjing Nongye Daxue xuebao (2013)

Junren Zhang

Solid H2O2 was prepared by anhydrous sodium sulfate,30% H2O2 solution and sodium chloride.Using the single-factor experimental design method,the impact of the material ratio,reaction temperature,reaction time,drying temperature on product yield and H2O2 content was studied to determine the optimum preparation technology.In addition,suspension quantitative germicidal test was carried out to know the germicidal efficacy.The results showed that the product was of a higher H2O2 content and good quality in the following condition,25 mL 30% H2O2,adding 32 g NaSO4,4 g NaCl,with the reaction time of 30 minutes,reaction temperature of 40 ℃,and the drying temperature of 60 ℃.10.8 g·L-1 H2O2 thimerosal killed 99.9% in average of Escherichia coli,Staphylococcus aureus with a 10 min contact and 100% in average of Bacillus cereus with a 1 h contact.Conclusion:solid H2O2 prepared in this test has a good bactericidal effect,and the preparation process is simple.

Anhydrous

Sodium sulfate

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Study on preparation and interferon inducing activity of tilorone dihydrochloride

Nanjing Nongye Daxue xuebao (2016)

Junren Zhang Jiang Shan-xiang Zuliang Liu

[Objectives]The aim of this paper was to make preparation and quality investigation of tilorone dihydrochloride. On the other hand,drug effect on induction of interferon was also primarily proved. [Methods]Tilorone was synthesized by the substitution reaction of 2,7-dihydroxy-9H-fluoren-9-one with 2-diethylaminoethyl chloride hydrochloride,which was then acidified to give tilorone dihydrochloride. The structure of target compound was characterized by Infrared Spectroscopy（ IR）, 1 H Nuclear Magnetic Resonance（ 1 H MNR） and mass spectrum（ MS）. By the method of pharmacopeia,physiochemical properties and content determination were identified in sequence for primary specification establishment. Tilorone dihydrochloride was dissolved at suitable concentration permitting an inoculum of 250 mg·kg -1 （ mice） orally. After tilorone challenged,mice were bled for IFN-α1assay via ELISA method.[Results]Tilorone dihydrochloride was synthesized in good yield of 93% and stable for quality control. In addition,tilorone could characteristically induce an unusually delayed and prolonged interferon response with peak level of 2 000 pg·m L -1 observed from12 h to 24 h. [Conclusions]The compound was efficient to prepare,and was stable and effective to induce obvious interferon responses,which will have broader prospects of development.

Hydrochloride

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塩酸替洛隆の調製とインターフェロン誘導能の検討【JST・京大機械翻訳】

Nanjing Nongye Daxue Xuebao (2016)

Junren Zhang Jiang Shan-xiang Zuliang Liu

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An Effective Synthesis Method for Tilorone Dihydrochloride with Obvious IFN-α Inducing Activity

Molecules (2015)

Junren Zhang Qizheng Yao Zuliang Liu

Tilorone dihydrochloride (1) has great potential for inducing interferon against pathogenic infection. In this paper, we describe a convenient preparation method for 2,7-dihydroxyfluoren-9-one (2), which is a usual pharmaceutical intermediate for preparing tilorone dihydrochloride (1). In the novel method, methyl esterification of 4,4′-dihydroxy-[1,1′-biphenyl]-2-carboxylic acid (4) was carried out under milder conditions with higher yield and played an important role in the preparation of compound 2. The structures of the relative intermediates and target compound were characterized by melting point, IR, MS, and 1H-NMR. Furthermore, the synthesized tilorone dihydrochloride exhibited an obvious effect on induction of interferon-α (IFN-α) in mice within 12 h, and the peak level was observed until 24 h. This fruitful work has resulted in tilorone dihydrochloride becoming available in large-scale and wide application in clinics, which has a good pharmaceutical development prospects.

Biphenyl

10.3390/molecules201219781

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Estimate of value of single pile ultimate bearing capacity with the CPT data

Jilin Geology (2011)

Junren Zhang

Taking an example,estimated the single pile ultimate bearing capacity with the CPT data,the estimate results were compared with the result of the traditional experience parameter estimate,meanwhile,the single pile static loading test data were verified,which indicates that the method is possible in this region.

Value (mathematics)

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Preparation of Management Planning for Highway Maintenance in Gansu

Junren Zhang

For there is rare systematic analysis and evaluation on highway maintenance and scientific decisions are rarely made by highway management departments,the necessity of highway maintenance is analyzed.Based on this,the content of highway maintenance planning and the technical route for preparation of maintenance planning are put forward.Thus,Highway Maintenance Management Planning of Gansu Province and the program to be implemented are prepared to ensure highways bringing transportation function into full play within design life.

Highway maintenance

Highway Engineering

Planned maintenance

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Cold-end Design Optimization of the 1000MW Ultra Supercritical Turbine Unit

Power Equipment (2012)

Junren Zhang

A study has been carried out to analyze the effects of steam turbine cold-end parameters on the thermal efficiency and operation economy of the power plant's thermodynamic system.Combined with the practical project,the cold-end design optimization for 2×1 000 MW ultra supercritical steam turbines has been described.The ways of reducing condenser pressure,temperature difference and terminal difference have been analyzed based on relevant principles.The design optimization and resulting effects for the condenser pressure and circulating water pump's configuration have been introduced with examples.

Condenser (optics)

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[The effects of twenty-one traditional Chinese medicines on tyrosinase].

PubMed (2002)

Jun Yan Changsheng Li Shengli Chen Junren Zhang Zhao Tianen

To study the effects of 21 kinds of traditional Chinese medicines on tyrosinase.The catalytic reactive velocity of tyrosinase was determined by vision spectrophotometry so as to evaluate the upregulation of traditional Chinese medicines extracts.21 time-curves of catalytic reaction of tyrosinase were obtained.13 kinds of traditional Chinese medicines extracts in vitro showed a upregulation to tyrosinase activity (P < 0.01). Scutellaria baicalensis and Cremastra appendiculata showed a better upregulation to tyrosinase activity.

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