Santosh Ghule

Savitribai Phule Pune University

Author Statistics

Papers

Citation

H-Index

i-10 index

Research Trends

Author Order

Document Type

Co-Authors

G. Vidyasagar

Sahyadri Hospital

Praveen Kumar Sharma

Guru Jambheshwar University of Science and Technology

Anil Bhandari

Jai Narain Vyas University

Praveen Kumar Sharma

Devi Ahilya Vishwavidyalaya

Neelam Balekar

IPS Academy

Kiran B Kotade

Shri Jagdishprasad Jhabarmal Tibrewala University

D. Kotresha

Davangere University

Sunder Singh

M.J.P. Rohilkhand University

Pankaj Dixit

J. S. Ayurveda Mahavidyalaya and P.D. Patel Ayurveda Hospital

Divakar Goli

Dr. Reddy's Laboratories (United States)

Cooperative Institutions

IPS Academy

Devi Ahilya Vishwavidyalaya

Hindu College of Pharmacy

Dr. Reddy's Laboratories (United States)

Jodhpur National University

Institute of Organic Chemistry

Prince of Songkla University

Sawai ManSingh Medical College and Hospital

Dr. Syamala Reddy Dental College Hospital & Research Center

Al-Ameen College of Pharmacy

Author Statistics

Papers

Citation

H-Index

i-10 index

Research Field

In vivo anti-inflammatory activity of Tabernaemontana divaricata leaf extract on male albino mice

Chinese Journal of Natural Medicines (2013)

Sachin Jain Praveen Kumar Sharma Santosh Ghule Ankit Jain Nitesh Jain

Croton

Croton oil

Anti-inflammatory

Decoction

Apocynaceae

Aqueous extract

10.1016/s1875-5364(13)60086-2

Cite

Citations (22)

Nanofabrication of Losartan Potassium Sustained Release Floating Microspheres using Different Grades of Ethyl Cellulose and its Insight on Release Profiles

Current Pharmaceutical Design (2024)

Tanavirsing Rajput Popat Mohite Santosh Ghule Kuldeep Vinchurkar Sudarshan Singh

Introduction: A sustained release system for losartan potassium designed to delay its residence time in the stomach through the preparation of solvent evaporation technique-based floating microspheres. The influence of the different grades of Ethocel™ such as 4 cps, 10 cps, and 22 cps as well as the drug: polymer ratio on various properties of microspheres were tested. Methods: Thermal and functional analysis revealed no interaction between the encapsulated drug and polymer. The results indicated that the mean diameter of microspheres increased with a change in grades of ethyl cellulose relating to viscosity. However, the drug incorporation efficiency within ethyl cellulose microspheres decreased with increasing viscosity of ethyl cellulose. Results: The bulk density of the formulations was proportionally dependent on concentration and the viscosity of the polymer, which resulted in a decrease in floating capacity from 90.02% to 73.58%. Moreover, the drug release was indirectly proportional to the viscosity of ethyl cellulose tested. The in vitro release profile exhibited a burst effect with a biphasic release pattern following Fickian diffusion, indicating a diffusioncontrolled release mechanism. Conclusion: The results demonstrated that the viscosity of ethyl cellulose significantly affects the floating capacity and drug release pattern from microspheres.

Losartan Potassium

10.2174/0113816128309675240530060752

Cite

Citations (1)

Pharmacological Activities of Leaves Extract of Calotropis procera (Asclepiadaceae)

Asian Journal of Chemistry (2014)

Santosh Ghule G. Vidyasagar Anil Bhandari Praveen Sharma Sachin Jain

Ethanolic extract of leaves of Calotropis procera (Asclepiadaceae) was tested for CNS activity like anticonvulsant, sedative and skeletal muscle relaxant activity.The extract of leaves of Calotropis procera orally in experimental animals at the dose level of 100, 200 and 500 mg/kg body weight.The anticonvulsant properties were studied on maximal electroshock test (MES) strychnine and PTZ-induced seizures model.Sedative property studied using actophotometer and skeletal muscle relaxant property studied using rotarod.C. procera ethanolic extract protected rats against maximal electroshock (MES) induced seizures.But had no or a moderate effect only against strychnine and PTZ-induced seizures.There was a decrease in the locomotor activity.The fall off time (motor coordination) was also decreased.No mortality was seen upto the dose of 2 g/kg.With these effects, the leaves of C. procera possess anticonvulsant, sedative and muscle relaxant effect that might explain its use as a traditional medicine.

Calotropis procera

Procera

10.14233/ajchem.2014.16365

Cite

Citations (0)

Quercetin Exerts Anti-convulsant Effects in Animal Model of Grand Mal Epilepsy: Modulation of GABA and Glycinergic Pathways

Journal of Drug Delivery and Therapeutics (2017)

Gaurav Parihar Bhubharti Dehariya Santosh Ghule Pankaj Dixit Neelam Balekar

Quercetin is low molecular weight flavonoid having multiple neuropharmacological actions. Recently, its anticonvulsant effect was reported in rats using electrical kindling models. However, earlier cell culture studies have documented antagonistic action of quercetin on GABAA, GABAC and Glycine channels, which is contrary to recent findings. Hence, the present study aimed at characterizing the effects of quercetin administration in various experimental models of epilepsy. Dose-dependent effects of quercetin on maximal-electroshock seizure (MES) were determined. Further, the effective dose was tested in pentylenetetrazol-induced seizures (PTZ), and strychnine-induced seizures to study the involvement of GABA and Glycinergic receptors. The results revealed a potent anticonvulsant effect of quercetin in MES induced seizures at a dose of 5 and 10 mg/kg. This effect was found to be retained in case of PTZ-induced convulsions and strychnine-induced convulsions (quercetin 10 mg/kg). The present finding warrants further substantiation along with their correlation to molecular mechanism of action.

Pentylenetetrazol

GABA receptor antagonist

10.22270/jddt.v7i7.1633

Cite

Citations (1)

International Journal of Pharmaceutical Sciences and Research (2023)

Santosh Ghule Praveen Kumar Sharma Kiran B Kotade T. A. Rajput Pande Samidha S.

Rheumatoid arthritis (RA) is a common chronic and systemic autoimmune disorder.It is characterized by inflammation of the synovial joints and concomitant destruction of cartilage and bone.However, rheumatoid arthritis is typically a progressive illness that has potential to cause joint destruction and functional disability.In the present research, GSH content were significantly decreased in arthritic control group when compared to normal control group.Treatment with TGF polysaccharides and TGF polysaccharides + glycyrrhizin, causes increase in GSH content, which was comparable with standard drug Dexamethasone.Change in body weight is in response to the incidence and severity of arthritis and used to assess disease onset.Weight loss is associated with increased production of proinflammatory cytokines such as tumor necrosis factor-alpha and interleukin-1.Adjuvant arthritis is characterized by reduced body weight.The body weight of arthritic control rats decreased compared to the normal control group due to FCA administration.Treatment with TGF polysaccharides and TGF polysaccharides + glycyrrhizin, recovered the body weights, significantly which was comparable with standard drug Dexamethasone. INTRODUCTION:Rheumatoid arthritis (RA) is a chronic, autoimmune disease that is considered a foremost health setback worldwide because approximately about 0.75% in India and 1% adult population in the world are exaggerated with this disease 1 .RA is most commonly seen in male population as compared to females, while the disease onset can occur between the ages of 30 and 55.

10.13040/ijpsr.0975-8232.14(2).816-26

Cite

Citations (0)

Antiulcer Activity of Leaves Extract of Murraya Koenigii In Experimentally Induced Ulcer In Rats.

Praveen Kumar Sharma G. Vidyasagar Anil Bhandari Sunder Singh Santosh Ghule

Summary The anti-ulcer activity of Aqueous extract of the leaves of Murraya koenigii was evaluated by using models of acute gastric lesions induced by ethanol induced, asprin induced, cold restrain stress and pylorus ligation in rats. Animals pretreated with doses of 200 mg/kg and 400 mg/kg of Aqueous extract showed significant reduction in lesion index, total affected area and percentage of lesion in comparison with control group in the ethanol induced, asprin induced, cold restraint stress-induced ulcer and pylorus ligation models. These findings indicate that aqueous extract of the leaves of Murraya koenigii displays good antiulcer activity, corroborating the folk use of Murraya koenigii preparations, and contributing for its pharmacological validation.

Murraya

Antidiarrhoeal

Ulcer index

Aqueous extract

Source

Cite

Citations (13)

Formulation and Evaluation of Clarithromycin Bioadhesive Tablets

Asian Journal of Chemistry (2016)

Atul Gunjal G. Vidyasagar Santosh Ghule

10.14233/ajchem.2016.19842

Cite

Citations (0)

Antidiarrhoeal activity of leaf extract of Celosia Argentea in experimentally induced diarrhoea in rats

Journal of Advanced Pharmaceutical Technology amp Research (2010)

Praveen Kumar Sharma G. Vidyasagar Sunder Singh Santosh Ghule Bimlesh Kumar

In order to scientifically apprise some of the anecdotal, folkloric, ethno medical uses of celosia argentea, the present study was undertaken to examine the antidiarrhoeal properties of alcoholic extract of leaves of Celosia argentea on diarrhoea by using different experimental models. Anti-diarrhoeal effect was evaluated by castor oil induced diarrhoea, charcoal meal test and PGE(2) induced diarrhoea. Loperamide (2 mg/kg) and atropine (0.1mg/kg) were used as standard drugs. Extract was used in 100 and 200 mg/kg dose. It produced dose related anti-diarrhoeal effect. Results suggest that it may act centrally and may inhibit the PGE(2) to give anti-diarrhoeal effects. Result of charcoal meal test also suggests its anti-muscarinic activity.

Antidiarrhoeal

Loperamide

Activated Charcoal

Dose dependence

10.4103/2231-4040.70521

Cite

Citations (32)

A pharmacological evaluation of antidiarrhoeal activity of leaves extract of Murraya koenigii in experimentally induced diarrhoea in rats

Asian Pacific Journal of Tropical Disease (2012)

Praveen Kumar Sharma G. Vidyasagar Anil Bhandari Sunder Singh Upendra Bhadoriya

To evaluate anti-diarrhoeal activity of aqueous and alcoholic extract of the leaves of Murraya koenigii (M. koenigii)by using models of castor oil induced diarrhoea, charcoal meal test and PGE2 induced diarrhoea. Alcoholic extract (400 mg/kg) and aqueous extract (200 mg/kg) of leaves of Murraya koenigii were used with loperamide as standard. Albino Wistar rats of both sexes weighing between 150–250 g were used for the anti-diarrhoeal activity. The result suggested that it could act centrally and inhibit the PGE2 to give anti-diarrhoeal effects. Result of charcoal meal test also suggested its anti-muscarnic activity. These findings indicate that aqueous extract of the leaves of M. koenigii displays good anti-diarrhoeal activity, corroborating the folk use of M. koenigii preparations and contributing for its pharmacological validation.

Antidiarrhoeal

Murraya

Loperamide

Aqueous extract

10.1016/s2222-1808(12)60052-8

Cite

Citations (20)

Anti-diabetic activity of Celosia argentea root in streptozotocin-induced diabetic rats

International Journal of Green Pharmacy (2010)

T Prakash D. Kotresha Roopa Karki V Surendra Divakar Goli

10.4103/0973-8258.69183

Cite

Citations (13)