Teruchika Sahashi

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Effects of Ca++-antagonists on systemic capacitance vessels and venous return curves of dogs. A study with mean circulatory pressure.

Japanese Circulation Journal (1988)

Yasunori Kotoo Hiroyasu Ito Teruchika Sahashi Hisayasu Wada Kuniyuki Takai

We measured mean circulatory pressure (MCP) in anesthetized, open-chest dogs before and after intravenous administration of Ca++-antagonists to estimate the effects on systemic capacitance vessels and on venous return (VR) curves both with and without continuous intravenous infusion of norepinephrine (NE). Diltiazem (300 micrograms/kg) decreased total peripheral resistance (TPR) and MCP significantly. Nifedipine (5 micrograms/kg), nicardipine (30 micrograms/kg) and verapamil (200 micrograms/kg) decreased TPR significantly without any change in MCP in the absence of NE, but with the exception of verapamil, they decreased MCP in the presence of NE. This indicates that diltiazem relaxed the systemic capacitance vessels, and nifedipine and nicardipine significantly decreased the tone of the systemic capacitance vessels that had been previously elevated by NE, but this action was very slight with verapamil. These Ca++-antagonists rotated VR curves clockwise, decreased resistance to VR (RVR) and increased VR both in the presence and absence of NE. It was suggested that the decrease in the RVR would be at least partially responsible for the increase in the VR.

Nicardipine

10.1253/jcj.52.1395

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Citations (5)

Effects of milrinone (Mil.) on systemic capacitance vessels, a study on the modifying effect of baroreceptor reflex on the measured mean Circulatory pressure (MCP) in dogs.

The Japanese Journal of Pharmacology (1989)

Hisayasu Wada Hiroyasu Ito Kijun Nagata Isao Hirose Teruchika Sahashi

Milrinone

10.1016/s0021-5198(19)56021-8

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Role of the ∝-adrenoceptor subtypes in constriction of the systemic capacitance vessels, a study with the measurement of mean circulatory pressure (MCP)

The Japanese Journal of Pharmacology (1986)

Isao Hirose Teruchika Sahashi Kijun Nagata Nobuyuki Takada Hiroyasu Ito

Constriction

10.1016/s0021-5198(19)59150-8

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Effects of captopril(CAP) on the systemic capacitance and resistance vessels

The Japanese Journal of Pharmacology (1988)

Teruchika Sahashi Hiroyasu Ito Kijun Nagata Isao Hirose Hisayasu Wada

Captopril

10.1016/s0021-5198(19)57225-0

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Differing actions of endothelin-1 on canine systemic resistance and capacitance vessels.

Japanese Circulation Journal (1992)

Kuniyuki Takai Hiroyasu Ito Teruchika Sahashi Hisayasu Wada Tomonori Segawa

In anesthetized open-chest dogs, an intravenous bolus injection of endothelin-1 (ET-1, 400 pmol/kg) caused transient hypotension (initial hypotensive phase; phase 1), followed by a continuous elevation of blood pressure (late hypertensive phase; phase 2). The constriction and dilation of the systemic capacitance and resistance vessels were evaluated from the change in mean circulatory pressure (MCP) and in total peripheral resistance (TPR) in phases 1 and 2. To examine the modification of the action of ET-1 on the blood vessels by the baroceptor reflex or by the endothelium-derived relaxing factor (EDRF) released by ET-1 in phase 1, we performed experiments in dogs under total spinal anesthesia (TSA group), methylene blue-treated dogs (MB group) as well as in the untreated dogs (control group). ET-1 decreased the TPR significantly, and increased the MCP significantly in phase 1 in the control (n=8) and TSA (n=8) groups; there was no difference between the groups. ET-1 had no significant effect on TPR but increased the MCP significantly in MB group (n = 8) during phase 1. The percentage increase of MCP in the MB group significantly ex-ceeded that of the control group. ET-1 increased both the TPR and MCP significantly in phase 2 in the control group (n=8). This study indicated that the vasocostrictor action of ET-1 on the systemic capacitance vessels in phase I did not result from a baroceptor reflex, and that the vasodilator action of ET-1 on the systemic resistance vessels may be at least in part mediated via EDRF released by ET-1. We suggest that the vasoconstrictor action of ET-1 on the systemic capacitance vessels is strong, but the vasodilator action of EDRF on the systemic capacitance vessels is weak.

Systemic circulation

10.1253/jcj.56.847

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Citations (5)

INHIBITORY EFFECTS OF NICARDIPINE (NIC) ON THE VASCULAR ACTION OF ENDOTHELIN (ET) IN PERFUSED CANINE FEMORAL ARTERY.

The Japanese Journal of Pharmacology (1991)

Kuniyuki Takai Hiroyasu Ito Kijun Nagata Isao Hirose Teruchika Sahashi

Nicardipine

10.1016/s0021-5198(19)39190-5

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Effects of ace inhibitor (captopril) on canine systemic capacitance vessels: A study with the measurement of mean circulatory pressure

Teruchika Sahashi Ito H Kijun Nagata Isao Hirose Hisayasu Wada

Captopril

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Citations (1)

Effects of Milrinone on Systemic Capacitance Vessels in Relation to Venous Return and Right Ventricular Pump Function

Journal of Cardiovascular Pharmacology (1992)

Senri Hirakawa Hiroyasu Ito Teruchika Sahashi Kuniyuki Takai Hisayasu Wada

Hirakawa, Senri; Ito, Hiroyasu; Sahashi, Teruchika; Takai, Kuniyuki; Wada, Hisayasu Author Information

Milrinone

Venous return curve

Ventricular Function

10.1097/00005344-199201000-00013

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Citations (6)

-126-ESTIMATION OF THE PRESENCE OF α-ADRENOCEPTOR SUBTYPES IN THE SYSTEMIC CAPACITANCE VESSELS IN DOGS : A STUDY WITH THE MEASUREMENT OF MEAN CIRCULATORY PRESSURE(MCP)

Japanese Circulation Journal (1986)

Isao Hirose Hiroyasu Ito Nobuyuki Takada Kijun Nagata Teruchika Sahashi

The purpose of thi$ elinical study is to investigate changes in left ventricular{LV) function and reflex sympathetic respose after d[ip infusion of nitroglyeerine{DIVTNC).In IS patients without abnormal LV wall motion, LV pressure, LV volume, right ventricular(RV) pressu[e, eorona[y sinus flow(CSF) and norepinephrine(NE) concentration in aorta and coronary sinus were measured in constant heart rate by atrtal pacing before and after DIVTNG.After DIVTNG",Smg during 20 minutes), positive dp/dt, dp/dtlP40 and Vrnax significantly tncreased by +9,IZ, +8.]Z and

10.1253/jcj.50.495_3

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Vasoconstrictor mechanism of endothelin-1 probably differs between canine systemic resistance and capacitance vessels

The Japanese Journal of Pharmacology (1992)

Hisayasu Wada Hiroyasu Ito Teruchika Sahashi Kuniyuki Takai Tomonori Segawa

Vasoconstrictor Agents

10.1016/s0021-5198(19)59943-7

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Citations (0)