Poster: ECR 2018 / C-3274 / Imaging of acute pancreatitis: update of the revised Atlanta classificaton by: F. Mutlu , A. S. Koksal, E. Parlak, A. Tocoglu, B. Toka; Sakarya/TR
Polycystic ovary syndrome (PCOS) is related to metabolic syndrome, insulin resistance, and cardiovascular metabolic syndromes. This is particularly true for individuals with central and abdominal obesity because visceral abdominal adipose tissue (VAAT) and epicardial adipose tissue (EAT) produce a large number of proinflammatory and proatherogenic cytokines. The present study aimed to determine whether there are changes in VAAT and EAT levels which were considered as indirect predictors for subclinical atherosclerosis in lean patients with PCOS. The clinical and demographic characteristics of 35 patients with PCOS and 38 healthy control subjects were recorded for the present study. Additionally, the serum levels of various biochemical parameters were measured and EAT levels were assessed using 2D-transthoracic echocardiography. There were no significant differences in mean age (p = 0.056) or mean body mass index (BMI) (p = 0.446) between the patient and control groups. However, the body fat percentage, waist-to-hip ratio, amount of abdominal subcutaneous adipose tissue, and VAAT thickness were higher in the PCOS patient group than in the control group. The amounts of EAT in the patient and control groups were similar (p = 0.384). EAT was correlated with BMI, fat mass, waist circumference, and hip circumference but not with any biochemical metabolic parameters including the homeostasis model assessment of insulin resistance index or the levels of triglycerides, low-density lipoprotein cholesterol, and high-density lipoprotein (HDL) cholesterol. However, there was a small positive correlation between the amounts of VAAT and EAT. VAAT was directly correlated with body fat parameters such as BMI, fat mass, and abdominal subcutaneous adipose thickness and inversely correlated with the HDL cholesterol level. The present study found that increased abdominal adipose tissue in patients with PCOS was associated with atherosclerosis. Additionally, EAT may aid in the determination of the risk of atherosclerosis in patients with PCOS because it is easily measured.
Amaç: Ailevi Akdeniz Ateşi (FMF) kronik inflamasyon ile karakterize bir hastalıktır. Bu hastalarında artmış sitokin maruziyeti ile birlikte kardiyovasküler hastalık (KVH) riskinde artış olması beklenir. Çalışmamızda FMF hastalarında KVH riskini belirlemek için serum lipid parametrelerini ile aterojenik indeksleri değerlendirmeyi amaçladık.
Yöntem: Çalışmada ataksız dönemdeki 102 FMF hastası ile 94 sağlıklı kontrol retrospektif olarak değerlendirildi. Katılımcıların verileri poliklinik verileri incelenerek hastane bilgi sistemi üzerinden kayıt edildi. Aterojenik indeksler lipid değerleri kullanılarak hesaplandı. FMF hastaları subklinik inflamasyonun varlığına göre iki gruba ayrıldı.
Bulgular: Total kolesterol (TK), düşük yoğunluklu lipoprotein kolesterol (LDL), aterojenik katsayı (AK), Castelli risk indeksi I ve II (CRI-I ve II) düzeylerinin FMF grubunda sağlıklı kontrollere göre istatistiksel olarak anlamlı oranda daha düşük olduğu tespit edildi (p
The novel coronavirus disease 2019 ) is an infectious disease that has been discovered recently.1 The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection initially manifests as an acute respiratory tract disease with interstitial and alveolar pneumonia; however, it may affect multiple organs such as kidney, heart, digestive system, blood and nervous system. 2The infection which began in Wuhan, the Hubei Province of China, in December 2019 and has rapidly spread, has raised concerns since it has become a global pandemic.COVID-19 progresses with increased morbidity and mortality in patients with chronic illnesses.
Abstract This study aimed to evaluate the relationship between -klotho levels and 25(OH)-vitamin D, calcium, phosphorus, and parathyroid hormone (PTH) in ankylosing spondylitis (AS) patients. Eighty-five patients aged 18-65, admitted to outpatient clinics between August 1 and September 1, 2019, were included. Patients with AS for at least 5 years (32, 37.6%) were assigned to the AS group, while those without known diseases (53, 62.4%) were placed in the healthy group. The -klotho level was 0.60 [0.33] ng/mL in the AS group and 0.68 [1.59] ng/mL in the healthy group (p=0.209). In the AS group, those with vitamin D deficiency had a klotho level of 0.599 [1.751] ng/mL, compared to 0.605 [0.499] ng/mL in those without (p=0.952). In the healthy group, levels were 1.309 [10.110] ng/mL and 0.641 [0.879] ng/mL, respectively (p=0.195). No significant relationships were found between -klotho levels and vitamin D, PTH, calcium, phosphorus, or ALP in either group. Although some studies suggest a link between vitamin D and -klotho, further research is needed.
Magnesium (Mg) deficiency is a common problem in diabetic patients. Deficiency of Mg may increase the incidence of diabetes mellitus (DM) and occurrence of diabetic complications. In this study, our aim was to evaluate an association between serum Mg level, glycemic regulation, and diabetic complications.In this retrospective study 673 diabetic patients were evaluated. According to Mg levels, the patients were divided into two groups; as normomagnesemic patients and hypomagnesemic patients.Among the patients, 57.8% were men and 42.2% were women. Mean age was 55.6 years and the mean duration of diabetes was 81 ± 86.9 months. The mean glycosylated hemoglobin (HbA1c) was 9.0 ±2.4 % (4.5-18); mean magnesium level was 1.97 ± 0.25 (1.13 to 3.0) mg / dl. There were 55 patients (8.2%) with diabetic retinopathy and 95 patients (14.1%) with diabetic neuropathy. Five hundred patients (74.3%) had normoalbuminuria; 133 patients (19. 8%) had microalbuminuria (MA) and 40 patients (5.9%) had overt proteinuria. One hundred and seventy one patients (25.4%) had HbA1c levels equal or below 7%; and 502 patients (74.6%) had HbA1c levels above 7%. There was no statistical difference in age or duration of diabetes between the groups formed according to Mg levels. Although there were no differences between the groups for retinopathy and neuropathy, MA was more common in hypomagnesemic patients (p =0.004). HbA1c levels did not differ between the groups (p =0.243). However there was a weak negative correlation between serum Mg and HbA1c levels (r =-0.110, p =0.004) and also between serum Mg and urine protein level (r =-0.127, p =0.018).Mg depletion is a common problem in patients with DM. It affects both glycemic regulation and the occurence of complications. Also, poor glycemic regulation affects serum Mg levels. Hippokratia 2015; 19 (2):153-157.
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