Hakan Aydın

Atatürk University

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i-10 index

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Yetmişbeş Yaş Üstü Hastalarda Koroner Baypass Cerrahisi ve Sonuçları

Turk Kardiyoloji Dernegi Arsivi-Archives of the Turkish Society of Cardiology (2002)

Hilmi Tokmakoğlu Özer Kandemir Bora Farsak Serdar Günaydın Hakan Aydın

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Potato wart disease survey in Turkey

EPPO Bulletin (2005)

Emel Çakır Hüseyin Duran Nedim ALTIN H. R. Akba Ö. Yeşilova

Synchytrium endobioticum was first detected in Turkey in 2003, in two areas remote from each other: two potato fields at Ordu and Giresun in the Black Sea region and adjacent potato fields at Nevşehir and Niğde in Central Anatolia. After an extensive survey carried out in the whole potato‐growing areas of Turkey, the disease was found only in these places. The disease was present in areas of 1999.7, 54.2, 9.2 and 1.5 ha in Nevşehir, Niğde, Ordu and Giresun provinces respectively in 2004. This comprises 1.8% of the total potato‐growing area.

Black Sea

10.1111/j.1365-2338.2005.00891.x

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Citations (1)

Anti-HEV Seroprevalence in Blood Donors in Erzurum

Viral Hepatitis Journal (2013)

Hakan Aydın M. Hamidullah Uyanık Ayşe Albayrak Erkan Özmen Osman Aktaş

© Viral Hepatit Dergisi, Ga le nos Ya y› ne vi ta ra f›n dan ba s›l m›fl t›r./ Viral Hepatitis Journal, pub lis hed by Ga le nos Pub lis hing. ABS TRACTObjective: Hepatitis E virus (HEV) is responsible for fecal-oral transmitted human acute hepatitis in endemic regions.Especially in non-endemic region, zoonotic transmission of hepatitis E raises an important public health concern over food safety and zoonotic risk.Previous seroprevalence studies have reported average rates of HEV seroprevalence about 6% in Turkey.This study was performed to determine hepatitis E virus seropositivity in blood donors and relation of seropositivity between age groups and sexes.Materials and Methods: A total of 248 blood donors were randomly selected and included the study.Anti-HEV IgG seropositivities were determined by ELISA.Results: HEV seropositivity was found in 10 (4.0%) of the donors.There were no significant differences among age groups and sexes.Conclusion: According to the results, HEV seroprevalence in Erzurum was found lower than the average seroprevalence of Turkey.The point that should not be ignored that, populations dealing with stockbreeding are at risk for zoonotic transmission.An extended seroepidemiological study on these populations with a detailed questionnaire may contribute to the identification of zoonotic risk factors.(Viral

Seroprevalence

10.4274/vhd.46855

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Citations (2)

Serological evidence of canine influenza virus infection in shelter dogs in Turkey

Medycyna Weterynaryjna (2018)

Hakan Aydın Akın Kirbaş Mehmet Özkan Timurkan Mustafa Sinan Aktaş Gülizar Acar Kırmızı

Influenza virus infection is an important disease which occurs in humans and a variety of animals. Because of the wide host adaptation and segmented genome, there is always the possibility of mutations and interspecies transmission of the influenza virus. Our study is the first to draw attention to canine influenza infection in Turkey. For this purpose, 208 sera and swab samples were collected from dogs with respiratory and nonrespiratory signs in various seasons. Out of the 208 dogs, 94 (45.2%) were male and 114 (54.8%) were female; the average age was 4.7 years. A total of 208 sera samples were tested for the presence of canine influenza virusspecific antibodies by the indirect enzyme-linked immunosorbent assay. The seroprevalence of canine influenza virus infection was 11/208 (5.8%). With regard to seasonal distribution, the highest rate of seropositivity was detected in spring, and the lowest in summer. Molecular detection of the canine influenza virus from nasal swab samples was done by reverse transcriptase polymerase chain reaction using specific universal primers for the hemagglutinin gene. Influenza virus nucleic acid could not be detected by reverse transcriptase polymerase chain reaction. In this study, we revealed for the first time the existence of the canine influenza virus in Turkey. Although the seroprevalence was relatively low, it would be useful to investigate the canine influenza virus on a large scale and among dogs with infectious respiratory disease in the Turkish dog population..

Seroprevalence

H5N1 genetic structure

10.21521/mw.5986

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Citations (3)

Preanalytical quality improvement – in quality we trust

Biochemia Medica (2013)

Giuseppe Lippi Gian Luca Salvagno Gabriel Lima-Oliveira D Funk-Adcock Gian Cesare Guidi

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Sitokinler ve Viral Enfeksiyonlardaki Rolü

Mehmet Özkan Timurkan Ayşe Tana Aslan Hakan Aydın

10.70269/10.70269/2474941887

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Evaluation of Serum Iron and Ferritin Levels as Inflammatory Markers in Calves with Bovine Respiratory Disease Complex

Acta veterinaria (2022)

Şükrü Değirmençay Akın Kirbaş Hakan Aydın Ömer AYDIN Mustafa Sinan Aktaş

Abstract Iron and ferritin have been used in human medicine for years to reveal the presence of inflammation. However, studies evaluating these parameters, especially in respiratory system diseases, are quite rare in veterinary medicine. We aimed to test the usability of serum Fe and Fe-related parameters [total iron-binding capacity (TIBC), unsaturated iron-binding capacity (UIBC) and transferrin saturation (TS) levels] as inflammatory and diagnostic biomarkers in calves with bovine respiratory disease complex (BRDC). To mark inflammation, some selected acute-phase proteins including serum ferritin and transferrin levels were measured because of their close relationship with iron metabolism. The material of this study consisted of 15 calves, aged 1-3 months with BRDC (Group I) and 10 healthy calves aged 1-3 months (Group II) based on the presence of respiratory clinical findings. Serum Fe, TIBC and TS levels were low and ferritin levels were high in Group I (P ≤ 0.001). The BRDC group was separated into two subgroups based on PCR results, namely Virus+ (n=9) and Virus- (n=6). The calves in the Virus+ group had significantly lower levels of Fe (P=0.001) and significantly higher values of ferritin (P=0.002), compared to the healthy group. On the basis of inter-group comparison and ROC analysis, we concluded that Fe (primarily), ferritin, TIBC and TS levels can be used as inflammatory biomarkers and possible diagnostic markers in the BRDC as useful, practical, inexpensive substitutes. As a suggestion, these parameters which are believed to play a role in the pathogenesis of the disease, can be used as potential prognostic biomarkers in studies involving treatment.

Transferrin saturation

Total iron-binding capacity

10.2478/acve-2022-0005

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Citations (3)

Molecular characterization of canine coronaviruses: an enteric and pantropic approach

Archives of Virology (2020)

Mehmet Özkan Timurkan Hakan Aydın Ender Dinçer Nüvit Coşkun

Canine coronavirus (CCoV) generally causes an infection with high morbidity and low mortality in dogs. In recent years, studies on coronaviruses have gained a momentum due to coronavirus outbreaks. Mutations in coronaviruses can result in deadly diseases in new hosts (such as SARS-CoV-2) or cause changes in organ-tissue affinity, as occurred with feline infectious peritonitis virus, exacerbating their pathogenesis. In recent studies on different types of CCoV, the pantropic strains characterized by hypervirulent and multi-systemic infections are believed to be emerging, in contrast to classical enteric coronavirus infections. In this study, we investigated emerging hypervirulent and multi-systemic CCoV strains using molecular and bioinformatic analysis, and examined differences between enteric and pantropic CCoV strains at the phylogenetic level. RT-PCR was performed with specific primers to identify the coronavirus M (membrane) and S (spike) genes, and samples were then subjected to DNA sequencing. In phylogenetic analysis, four out of 26 samples were classified as CCoV-1. The remaining 22 samples were all classified as CCoV-2a. In the CCoV-2a group, six samples were in branches close to enteric strains, and 16 samples were in the branches close to pantropic strains. Enteric and pantropic strains were compared by molecular genotyping of CCoV in dogs. Phylogenetic analysis of hypervirulent pantropic strains was carried out at the amino acid and nucleotide sequence levels. CCoV was found to be divergent from the original strain. This implies that some CCoV strains have become pantropic strains that cause multisystemic infections, and they should not be ruled out as the cause of severe diarrhea and multisystemic infections.

Coronavirus

Feline infectious peritonitis

Coronaviridae

Bovine coronavirus

10.1007/s00705-020-04826-w

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Citations (20)

The Immunostimulatory Effect of Lactic Acid Bacteria in a Rat Model.

PubMed (2016)

Murat Karameşe Hakan Aydın Emin Şengül Volkan Gelen Çiğdem Sevim

Probiotics are "live", beneficial microbes that provide important health benefits in their hosts. There is significant interest in the modulation and regulation of the immune function by probiotics.To investigate the immunomodulatory effects of a probiotic mixture, including Lactobacillus and Bifidobacterium species, by detecting serum cytokine and immunoglobulin levels.The rats were randomly divided into 4 groups. The first group was "Control group" and other 3 groups were probiotic application groups who received different doses of probiotics. The probiotic mixture included 12 probiotic bacteria, mostly Lactobacillus and Bifidobacterium strains. Probiotic mixture was administered to rats for 12 consecutive days. TNF-α, TGF-β, IL-1-β, IL-6, and IL-10 levels as well as serum IgG and IgA concentrations were detected in the sera after 12 days.Probiotics led to a decrease in the levels of TNF-α, IL-6 and TGF-β; however, they led to increase in the serum levels of IL-10, IgG and IgA. There were significant differences between control group and probiotic application groups (p<0.05).These data suggest that the commensal microbiota are important for stimulating both proinflammatory and regulatory responses in order to rapidly clear infections and minimize inflammation-associated tissue damage.

Proinflammatory cytokine

Immunoglobulin A

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Serological Investigation of Occupational Exposure to Zoonotic Crimean-Congo Hemorrhagic Fever Infection

Eurasian Journal of Medicine (2020)

Hakan Aydın M. Hamidullah Uyanık Murat Karameşe İbrahim Sözdutmaz Mehmet Özkan Timurkan

Crimean-Congo hemorrhagic fever (CCHF) is an acute and highly fatal disease. In this study, our aim was to compare and evaluate the prevalence of CCHF virus (CCHFV) antibody among occupational high-risk groups by using the enzyme-linked immunosorbent assay and draw attention to the occupational groups that are at high risk for CCHF infection in an endemic region for this zoonotic infection in Erzurum, Turkey.The antibody levels against CCHFV were surveyed among slaughterhouse workers, animal breeders, and veterinarians. The study population was composed of 72 participants having direct contact with animals and 19 blood donors who were not in direct contact with animals.The overall rate of CCHF immunoglobulin G positivity in risk groups was found to be 6.94% (5/72). CCHFV antibodies were found in 4 (12.5%) individuals of the animal breeder group. This ratio was considered significantly higher compared with the healthy control group. CCHFV antibodies were found in only one person (4.0%) who was an abattoir worker. In the veterinarian group, all people were found negative.In our study, the variables showing important associations with the prevalence of anti-CCHFV antibodies were livestock breeding, rural areas, and age. It was concluded that our region is endemic with regard to CCHF infection and persons who had direct contact with animals are at high risk. Thus, these participants must take necessary measures to protect themselves from CCHF and should be trained by health authorities.

Crimean–Congo hemorrhagic fever

Seroprevalence

10.5152/eurasianjmed.2020.19176

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Citations (5)