Tilahun Ayane Debele

University of Cincinnati

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Hsieh‐Chih Tsai

National Taiwan University of Science and Technology

Shewaye Lakew Mekuria

Donghua University

Wen‐Pin Su

National Cheng Kung University Hospital

Chun-Liang Lo

National Yang Ming Chiao Tung University

Lu-Yi Yu

National Yang Ming Chiao Tung University

Yoonjee C. Park

University of Cincinnati

Yao Shen

Taipei Medical University

Jian‐Ying Chuang

Taipei Medical University

Yoonjee Park

University of Cincinnati

Mohd Murtaza

Indian Institute of Integrative Medicine

Cooperative Institutions

National Tsing Hua University

National Cheng Kung University

National Yang Ming Chiao Tung University

National Taiwan University of Science and Technology

University of Cincinnati

Taipei Medical University

University of Cincinnati Medical Center

National Cheng Kung University Hospital

National Yang Ming University Hospital

National Health Research Institutes

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POLYSACCHARIDE BASED NANOCARRIERS FOR ANTICANCER DRUG AND PHOTOSENSITIZER DELIVERY TO ENHANCE CHEMOTHERAPEUTIC EFFICIENCY AND PHOTODYNAMIC THERAPY OF CANCERS

Tilahun Ayane Debele

Nanocarriers

Anticancer drug

Chemotherapeutic drugs

Targeted drug delivery

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Synergistic Action of Immunotherapy and Nanotherapy against Cancer Patients Infected with SARS-CoV-2 and the Use of Artificial Intelligence

Cancers (2022)

Tanvi Gupta Tilahun Ayane Debele Yufeng Wei Anish Gupta Mohd Murtaza

Since 2019, the SARS-CoV-2 pandemic has caused a huge chaos throughout the world and the major threat has been possessed by the immune-compromised individuals involving the cancer patients; their weakened immune response makes them vulnerable and susceptible to the virus. The oncologists as well as their patients are facing many problems for their treatment sessions as they need to postpone their surgery, chemotherapy, or radiotherapy. The approach that could be adopted especially for the cancer patients is the amalgamation of immunotherapy and nanotherapy which can reduce the burden on the healthcare at this peak time of the infection. There is also a need to predict or analyze the data of cancer patients who are at a severe risk of being exposed to an infection in order to reduce the mortality rate. The use of artificial intelligence (AI) could be incorporated where the real time data will be available to the physicians according to the different patient's clinical characteristics and their past treatments. With this data, it will become easier for them to modify or replace the treatment to increase the efficacy against the infection. The combination of an immunotherapy and nanotherapy will be targeted to treat the cancer patients diagnosed with SARS-CoV-2 and the AI will act as icing on the cake to monitor, predict and analyze the data of the patients to improve the treatment regime for the most vulnerable patients.

Pandemic

Cancer Treatment

10.3390/cancers14010213

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Citations (2)

Drug delivery systems for wound healing treatment of upper airway injury

Expert Opinion on Drug Delivery (2024)

D. Cruz Avery Zheng Tilahun Ayane Debele Peter J. Larson Gregory R. Dion

Endotracheal intubation is a common procedure to maintain an open airway with risks for traumatic injury. Pathological changes resulting from intubation can cause upper airway complications, including vocal fold scarring, laryngotracheal stenosis, and granulomas and present with symptoms such as dysphonia, dysphagia, and dyspnea. Current intubation-related laryngotracheal injury treatment approaches lack standardized guidelines, relying on individual clinician experience, and surgical and medical interventions have limitations and carry risks.

10.1080/17425247.2024.2340653

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IL-6 Antibody and RGD Peptide Conjugated Poly(amidoamine) Dendrimer for Targeted Drug Delivery of HeLa Cells

The Journal of Physical Chemistry B (2015)

Shewaye Lakew Mekuria Tilahun Ayane Debele Hsiao-Ying Chou Hsieh‐Chih Tsai

In this study, PAMAM dendrimer (G4.5) was conjugated with two targeting moieties, IL-6 antibody and RGD peptide (G4.5-IL6 and G4.5-RGD conjugates). Doxorubicin anticancer drug was physically loaded onto G4.5-IL6 and G4.5-RGD with the encapsulation efficiency of 51.3 and 30.1% respectively. The cellular internalization and uptake efficiency of G4.5-IL6/DOX and G4.5-RGD/DOX complexes was observed and compared by confocal microscopy and flow cytometry using HeLa cells, respectively. The lower IC50 value of G4.5-IL6/DOX in comparison to G4.5-RGD/DOX is indication that higher drug loading and faster drug release rate corresponded with greater cytotoxicity. The cytotoxic effect was further verified by increment in late apoptotic/necrotic cells due to delivery of drug through receptor-mediated endocytosis. On the basis of these results, G4.5-IL6 is a better suited carrier for targeted drug delivery of DOX to cervical cancer cells.

HeLa

Internalization

Targeted drug delivery

10.1021/acs.jpcb.5b11125

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Drug Carrier for Photodynamic Cancer Therapy

International Journal of Molecular Sciences (2015)

Tilahun Ayane Debele Sydney Peng Hsieh‐Chih Tsai

Photodynamic therapy (PDT) is a non-invasive combinatorial therapeutic modality using light, photosensitizer (PS), and oxygen used for the treatment of cancer and other diseases. When PSs in cells are exposed to specific wavelengths of light, they are transformed from the singlet ground state (S₀) to an excited singlet state (S₁-Sn), followed by intersystem crossing to an excited triplet state (T₁). The energy transferred from T₁ to biological substrates and molecular oxygen, via type I and II reactions, generates reactive oxygen species, (¹O₂, H₂O₂, O₂*, HO*), which causes cellular damage that leads to tumor cell death through necrosis or apoptosis. The solubility, selectivity, and targeting of photosensitizers are important factors that must be considered in PDT. Nano-formulating PSs with organic and inorganic nanoparticles poses as potential strategy to satisfy the requirements of an ideal PDT system. In this review, we summarize several organic and inorganic PS carriers that have been studied to enhance the efficacy of photodynamic therapy against cancer.

Cancer Therapy

Cancer drugs

10.3390/ijms160922094

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Citations (222)

Encapsulation of Gadolinium Oxide Nanoparticle (Gd₂O₃) Contrasting Agents in PAMAM Dendrimer Templates for Enhanced Magnetic Resonance Imaging in Vivo

ACS Applied Materials & Interfaces (2017)

Shewaye Lakew Mekuria Tilahun Ayane Debele Hsieh‐Chih Tsai

There has been growing interest in the research of nanomaterials for biomedical applications in recent decades. Herein, a simple approach to synthesize the G4.5-Gd2O3-poly(ethylene glycol) (G4.5-Gd2O3-PEG) nanoparticles (NPs) that demonstrate potential as dual (T1 and T2) contrasting agents in magnetic resonance imaging (MRI) has been reported in this study. Compared to the clinically popular Gd-DTPA contrasting agents, G4.5-Gd2O3-PEG NPs exhibited a longer longitudinal relaxation time (T1) and better biocompatibility when incubated with macrophage cell line RAW264.7 in vitro. Furthermore, the longitudinal relaxivity (r1) of G4.5-Gd2O3-PEG NPs was 53.9 s-1 mM-1 at 7T, which is equivalent to 4.8 times greater than to the Gd-DTPA contrasting agents. An in vivo T1-weighted MRI results revealed that G4.5-Gd2O3-PEG NPs significantly enhanced signals in the intestines, kidney, liver, bladder, and spleen. In addition, the T2-weighted MRI results revealed darker contrast in the kidney, which proves that G4.5-Gd2O3-PEG NPs can be exploited as T1 and T2 contrasting agents. In summary, these findings suggest that the G4.5-Gd2O3-PEG NPs synthesized by an alternative approach can be used as dual MRI contrasting agents.

Template

Encapsulation

10.1021/acsami.6b14075

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Citations (81)

Lipopolyplex-Mediated Co-Delivery of Doxorubicin and FAK siRNA to Enhance Therapeutic Efficiency of Treating Colorectal Cancer

Pharmaceutics (2023)

Tilahun Ayane Debele Chi-Kang Chen Lu-Yi Yu Chun-Liang Lo

Tumor metastasis is a major concern in cancer therapy. In this context, focal adhesion kinase (FAK) gene overexpression, which mediates cancer cell migration and invasion, has been reported in several human tumors and is considered a potential therapeutic target. However, gene-based treatment has certain limitations, including a lack of stability and low transfection ability. In this study, a biocompatible lipopolyplex was synthesized to overcome the aforementioned limitations. First, polyplexes were prepared using poly(2-Hydroxypropyl methacrylamide-co-methylacrylate-hydrazone-pyridoxal) (P(HPMA-co-MA-hyd-VB6)) copolymers, which bore positive charges at low pH value owing to protonation of pyridoxal groups and facilitated electrostatic interactions with negatively charged FAK siRNA. These polyplexes were then encapsulated into methoxy polyethylene glycol (mPEG)-modified liposomes to form lipopolyplexes. Doxorubicin (DOX) was also loaded into lipopolyplexes for combination therapy with siRNA. Experimental results revealed that lipopolyplexes successfully released DOX at low pH to kill cancer cells and induced siRNA out of endosomes to inhibit the translation of FAK proteins. Furthermore, the efficient accumulation of lipopolyplexes in the tumors led to excellent cancer therapeutic efficacy. Overall, the synthesized lipopolyplex is a suitable nanocarrier for the co-delivery of chemotherapeutic agents and genes to treat cancers.

Nanocarriers

Asialoglycoprotein receptor

Methacrylamide

10.3390/pharmaceutics15020596

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Citations (7)

A pH-sensitive micelle composed of heparin, phospholipids, and histidine as the carrier of photosensitizers: Application to enhance photodynamic therapy of cancer

International Journal of Biological Macromolecules (2017)

Tilahun Ayane Debele Shewaye Lakew Mekuria Hsieh‐Chih Tsai

Zeta potential

Phototoxicity

10.1016/j.ijbiomac.2017.01.103

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Citations (33)

Polysaccharide based nanogels in the drug delivery system: Application as the carrier of pharmaceutical agents

Materials Science and Engineering C (2016)

Tilahun Ayane Debele Shewaye Lakew Mekuria Hsieh‐Chih Tsai

Biocompatibility

Bioconjugation

Nanogel

10.1016/j.msec.2016.05.121

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Citations (276)

Application of Nanoparticles: Diagnosis, Therapeutics, and Delivery of Insulin/Anti-Diabetic Drugs to Enhance the Therapeutic Efficacy of Diabetes Mellitus

Life (2022)

Tilahun Ayane Debele Yoonjee Park

Diabetes mellitus (DM) is a chronic metabolic disorder of carbohydrates, lipids, and proteins due to a deficiency of insulin secretion or failure to respond to insulin secreted from pancreatic cells, which leads to high blood glucose levels. DM is one of the top four noncommunicable diseases and causes of death worldwide. Even though great achievements were made in the management and treatment of DM, there are still certain limitations, mainly related to the early diagnosis, and lack of appropriate delivery of insulin and other anti-diabetic agents. Nanotechnology is an emerging field in the area of nanomedicine and NP based anti-diabetic agent delivery is reported to enhance efficacy by increasing bioavailability and target site accumulation. Moreover, theranostic NPs can be used as diagnostic tools for the early detection and prevention of diseases owing to their unique biological, physiochemical, and magnetic properties. NPs have been synthesized from a variety of organic and inorganic materials including polysaccharides, dendrimers, proteins, lipids, DNA, carbon nanotubes, quantum dots, and mesoporous materials within the nanoscale size. This review focuses on the role of NPs, derived from organic and inorganic materials, in the diagnosis and treatment of DM.

10.3390/life12122078

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Citations (11)