Denis Baranenko

ITMO University

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ВГ

В. Г. Беспалов

Ministry of Health of the Russian Federation

Weihong Lu

Harbin Institute of Technology

ЛН

Людмила Надточий

Saint - Petersburg State Chemical Pharmaceutical Academy

АЛ

А. Л. Семенов

Institute of Oncology NN Petrov

A.M. Abd El‐Aty

Cairo University

Tamer M. El‐Messery

ITMO University

A.I. Lepeshkin

ITMO University

Mohamed Said Boulkrane

ITMO University

Julia Fedotova

Pavlov Institute of Physiology of the Russian Academy of Sciences

Wenchen Yu

Harbin Institute of Technology

Cooperative Institutions

ITMO University

Harbin Institute of Technology

Ministry of Health of the Russian Federation

Comenius University Bratislava

Institute of Oncology NN Petrov

Martin University Hospital

Chinese Academy of Sciences

Russian Academy of Sciences

University of Pretoria

Shanghai Jiao Tong University

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Rheological and physical–chemical properties of yogurt with oat–chia seeds composites

Agronomy Research (2020)

Людмила Надточий Denis Baranenko Wen Hua Lu Anna Safronova A.I. Lepeshkin

10.15159/ar.20.142

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Citations (4)

HARMONIZED STATISTICAL ANALYSIS OF THE EFFICACY OF INTRAPERITONEAL CHEMOTHERAPY REGIMENS WITH DIOXADET ON ASCITIC OVARIAN CANCER MODEL

Voprosy Onkologii (2017)

В. Г. Беспалов Aleksey Belyaev Denis Baranenko Н. Н. Хромов-Борисов Valeriy Aleksandrov

A comparative statistical study of the results of eight independent experiments on the efficacy of intraperitoneal chemotherapy has been performed. The regiments of cathether intraperitoneal chemotherapy (CIPC), normothermic and hyperthermic chemoperfusion (NIPEC and HIPEC) with antitumor drug dioxadet were investigated in 288 female Wistar rats with ascitic ovarian cancer. Ovarian cancer was transplanted intra-peritoneally (i.p.) 48 hours prior to a single chemotherapy at a number of 1*107 tumor cells. Dioxadet was administered at the maximum tolerated doses: CIPC - via syringe - 1.5 mg/kg body weight; NIPEC (36,5-37,5°С) and HIPEC (40,5-41,5°С) - infused for a continuous circulation using an experimental setting - at respective doses 30 and 15 mg/kg body weight. The rats in the control groups were administered in the same manner with physiological saline solution. The antitumor effects of the treatment were estimated as an increase in survival time. The statistical analysis was based on the principles of harmonization of statistical evidence and predictions. The mean survival time in the control group without treatment (i.p. saline injection) was 15 days with 95% confidence interval (CI) from 12 to 19 days. IPC, NIPEC and HIPEC increased mean survival time by 85, 97 and 202% (p

Intraperitoneal Chemotherapy

Hyperthermic Intraperitoneal Chemotherapy

10.37469/0507-3758-2017-63-2-329-335

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Mutation analysis of POLE gene in patients with early-onset colorectal cancer revealed a rare silent variant within the endonuclease domain with potential effect on splicing

Clinical and Experimental Medicine (2019)

Zora Lasabová Michal Kalman Veronika Holubeková Marián Grendár Ivana Kašubová

MUTYH

Sanger sequencing

Microsatellite Instability

10.1007/s10238-019-00558-7

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Citations (9)

Rapid and sensitive detection of nucleoprotein SARS-CoV-2 virus: SERS vs ELISA

Photonics and Nanostructures - Fundamentals and Applications (2023)

Landysh I. Fatkhutdinova Ekaterina Babich К. Н. Болдырев Sergei A. Shipilovskikh Ivan Terterev

Nucleoprotein

Point of care

10.1016/j.photonics.2023.101172

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Citations (2)

Probiotics viability in frozen food products

Food Bioscience (2022)

Nikita Tyutkov Anastasia Zhernyakova A. A. Birchenko Elmira R. Eminova Людмила Надточий

Cryoprotectant

Food Preservation

Food Products

10.1016/j.fbio.2022.101996

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Citations (23)

Increasing of Food and Bioenergy Potato Resources by Microbial Influence on Tubers Phytohormonal Status

Environmental and Climate Technologies (2014)

Elena I. Kiprushkina Denis Baranenko

Abstract Potato and its by-products became a promising both food and bioenergy resource. The determination of the bacteriaantagonists influence on phytohormone status and productivity of potato tubers was studied. The indole-3-acetic acid content during the dormancy end and germinating in the tubers treated with Bacillus subtilis Ch-13 was fewer than in the control samples. L-tryptophan significant quantity compared to the control was found in the treated tubers in a state of physiological dormancy (more than 2-fold) and especially during active germination (43 times greater). Average potato yield increase at treated fields was of 18.8 %.

10.1515/rtuect-2014-0012

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Citations (8)

The inhibitory effect of meadowsweet (Filipendula ulmaria) on radiation-induced carcinogenesis in rats

International Journal of Radiation Biology (2016)

В. Г. Беспалов Valery A. Alexandrov А. Л. Семенов Kovan'ko Eg Sergey D. Ivanov

To examine the ability of the meadowsweet preparation to inhibit carcinogenesis induced by ionizing radiation in female rats.The chemical composition of meadowsweet (Filipendula ulmaria) raw material (ethanol and aqueous extracts of meadowsweet flowers) has been studied for the presence of flavonoids, tannins and catechins. Adult female LIO strain rats were subjected to a single whole body γ-irradiation at a dose of 4 Gy in animal experiments. One group of irradiated rats served as control while the other group, starting from the 10th day after irradiation and until the end of the experiment, was given meadowsweet as a decoction of the flowers instead of drinking water. The average daily intake of meadowsweet (dry raw material) was 1 g/kg body weight. Rats were observed for 16 months.The analyzed meadowsweet extracts showed a sufficiently high content of flavonoids and tannins. In irradiated rats after 16 months the overall incidence of tumors was 79.6% (in 82 of 103 rats), the incidence of malignant tumors was 43.7% and the overall tumor multiplicity was 1.48. Most tumors were localized in the mammary gland - 57.3%. In rats that received meadowsweet, the incidence of all malignant tumors and overall multiplicity of tumors were significantly decreased by 1.5 and 1.3 times, respectively. The greatest reduction of many parameters has been identified for breast tumors: the overall incidence was decreased by 1.5 (p = 0.0174) and the overall multiplicity and multiplicity of malignant tumors - by 1.6 (p = 0.0002) and 2.2 (p = 0.0383) times, respectively.Meadowsweet preparation showed inhibiting activity on radiation carcinogenesis.

10.1080/09553002.2016.1257834

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Citations (8)

Using soy protein in the three-component phantom for breast cancer mimicking

Journal of Physics Conference Series (2020)

Quentin Cassar Anastasiya A. Lykina A.I. Lepeshkin Denis Baranenko Olga V. Kravtsenyuk

Abstract Creation of the biological tissue phantoms especially breast tissue cancer in the terahertz frequency range is an actual problem of medical physics. This paper suggests using soy protein as one of the main component of breast tissue phantom instead of gelatin, as it’s water-and fat-holding substance, “quasi-bioidentical” to animal proteins and their chemical characteristics are stable in time. Implemented phantoms were analyzed experimentally by using terahertz pulsed spectroscopy, obtained results were compared with spectra of adipose, fibrous and cancer tissue (human female breast tissue).

Breast tissue

Biological tissue

Component (thermodynamics)

Gelatin

10.1088/1742-6596/1537/1/012019

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The role of dietary phytochemicals in the carcinogenesis via the modulation of miRNA expression

Journal of Cancer Research and Clinical Oncology (2019)

Marek Samec Alena Líšková Peter Kubatka Sona Uramova Pavol Žúbor

10.1007/s00432-019-02940-0

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