Zhijiang Ge

Tianjin University of Science and Technology

Author Statistics

Papers

Citation

H-Index

i-10 index

Research Trends

Author Order

Document Type

Co-Authors

Shuhong Mao

Tianjin University of Science and Technology

Fuping Lu

Tianjin University of Science and Technology

Xuerong Wang

Northwest A&F University

Lixia Zhang

Chinese Academy of Medical Sciences & Peking Union Medical College

Xiaoguang Liu

Peking University Third Hospital

Yanqing Li

Tianjin University

Yanqing Li

Qilu Hospital of Shandong University

An Su

Zhejiang University of Technology

Fei Liu

Chinese Academy of Sciences

Xiaoguang Liu

Peking University Third Hospital

Cooperative Institutions

Tianjin University of Science and Technology

Chinese Academy of Sciences

Ministry of Education of the People's Republic of China

East China Normal University

Sun Yat-sen University

Peking University

Ministry of Agriculture and Rural Affairs

Chinese Academy of Medical Sciences & Peking Union Medical College

Northwest A&F University

Peking University Third Hospital

Author Statistics

Papers

Citation

H-Index

i-10 index

Research Field

CCDC 967633: Experimental Crystal Structure Determination

The Cambridge Structural Database (2019)

Shuhong Mao Xuerong Wang Zhijiang Ge An Su Lixia Zhang

10.5517/ccdc.csd.cc11gwzc

Cite

Citations (0)

CCDC 967631: Experimental Crystal Structure Determination

The Cambridge Structural Database (2016)

Shuhong Mao Lixia Zhang Zhijiang Ge Xuerong Wang Yanqing Li

10.5517/ccdc.csd.cc11gwx9

Cite

Citations (0)

[16β-hydroxylation of 4-androstene-3,17-dione by Aspergillus niger].

PubMed (2014)

Zhijiang Ge Shuhong Mao Yanqing Li Xiaoguang Liu Fuping Lu

In order to discover the steroid biotransformation ability of filamentous fungus Aspergillus niger TCCC41650, we studied the fermentation of 4-androstene-3,17-dione with A. niger TCCC41650. The transformation product was purified, crystallized and determined as 16β-hydroxy-androst-4-ene-3,17-dione by X-ray single crystal diffraction method. The best fermentation condition was found to be pH 6.0, ethanol amount 2% with a substrate concentration of 1 per thousand, the transformation rate is 85.81% after 72 h. Based on the best of our knowledge, 16β-hydroxylation rarely occurs in microbial transformations of steroid. This study laid the foundation for the research of 16β-hydroxylation steroids

Aspergillus niger

Hydroxylation

Biotransformation

Source

Cite

Citations (4)

11α hydroxylation of 16α, 17‐epoxyprogesterone in biphasic ionic liquid/water system by Aspergillus ochraceus

Journal of Chemical Technology & Biotechnology (2012)

Shuhong Mao Boyuan Hua Na Wang Xiaojie Hu Zhijiang Ge

Abstract BACKGROUND: The improved efficiency of steroid biotransformation using the biphasic system is generally attributed to the positive effect on the solubility of substrate in aqueous media. A promising alternative for the application of organic solvents in biphasic systems is the use of ionic liquids (ILs). This study aims to investigate the applicability of the biphasic ILs/water system for 11α hydroxylation of 16α, 17‐epoxyprogesterone (HEP) by Aspergillus ochraceus . RESULTS: Of the seven ILs tested, [C 3 mim][PF 6 ] exhibited the best biocompatibility, with markedly improved biotransformation efficiency. In the [C 3 mim][PF 6 ]‐based biphasic system, substrate conversion reached 90% under the condition in which buffer pH, volume ratio of buffer to ILs, cell concentration, and substrate concentration were 4.8, 10/1, 165 g L −1 and 20 g L −1 , respectively. This is more efficient than that of the monophasic aqueous system. The effects of the cations and anions of these ILs on the 11α hydroxylation of 16α, 17‐epoxyprogesterone (HEP) by A. ochraceus is also discussed. CONCLUSION: The above results showed that IL/water biphasic system improved the efficiency of 11α hydroxylation of 16α, 17‐epoxyprogesterone (HEP) by A. ochraceus, thus suggesting the potential industrial application of ILs‐based biphasic systems for steroid biotransformation. © 2012 Society of Chemical Industry

Aspergillus ochraceus

Hydroxylation

Biotransformation

10.1002/jctb.3828

Cite

Citations (20)

CCDC 967634: Experimental Crystal Structure Determination

The Cambridge Structural Database (2019)

Shuhong Mao Xuerong Wang Zhijiang Ge An Su Lixia Zhang

10.5517/ccdc.csd.cc11gx0f

Cite

Citations (0)

Microbial hydroxylation of steroids by Penicillium decumbens

Journal of Molecular Catalysis B Enzymatic (2016)

Shuhong Mao Lixia Zhang Zhijiang Ge Xuerong Wang Yanqing Li

Biotransformation

Hydroxylation

Biocatalysis

10.1016/j.molcatb.2017.02.007

Cite

Citations (10)

CCDC 967632: Experimental Crystal Structure Determination

The Cambridge Structural Database (2016)

Shuhong Mao Lixia Zhang Zhijiang Ge Xuerong Wang Yanqing Li

10.5517/ccdc.csd.cc11gwyb

Cite

Citations (0)

Using Water Miscible Ionic Liquid to Improve the Efficiency of 15α-hydroxylation of 13-ethyl-gon-4-en-3,17-dione by Penicillium raistrickii

Lecture notes in electrical engineering (2013)

Shuhong Mao Na Wang Zhijiang Ge Boyuan Hua Yanqing Li

Hydroxylation

10.1007/978-3-642-37922-2_84

Cite

Citations (0)

Microbial Hydroxylation of 16α, 17α-Epoxyprogesterone by

PubMed (2017)

Shuhong Mao Xuerong Wang Zhijiang Ge An Su Lixia Zhang

Microbial transformation has been successfully applied in the production of steroid intermediates with therapeutic use and commercial value in pharmaceutical industry due to its high regio- and stereo-selectivity. As such, it is still important to screen microbial strains with novel activity or more efficient abilities in the development of the commercial steroid industry. Biotransformation of steroid: 16α, 17α-epoxyprogesterone (1). using

Hydroxylation

Biotransformation

Biocatalysis

Source

Cite

Citations (2)

CCDC 1491778: Experimental Crystal Structure Determination

The Cambridge Structural Database (2016)

Shuhong Mao Lixia Zhang Zhijiang Ge Xuerong Wang Yanqing Li

10.5517/ccdc.csd.cc1m29ww

Cite

Citations (0)