Peter Abdou

University of California, Los Angeles

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Zhen Gu

Zhejiang University

Gianpietro Dotti

University of North Carolina at Chapel Hill

Zejun Wang

Yunnan Agricultural University

Guojun Chen

McGill University

Jinqiang Wang

Zhejiang University

Hongjun Li

Zhejiang University

Di Wen

Hebei Medical University

Quanyin Hu

University of Wisconsin–Madison

George A. Van Den Driessche

Biogen (United States)

Denis Fourches

North Carolina State University

Cooperative Institutions

University of California, Los Angeles

California NanoSystems Institute

North Carolina State University

Zhejiang University

Chinese Academy of Sciences

University of North Carolina at Chapel Hill

Sichuan University

Chinese Academy of Medical Sciences & Peking Union Medical College

Nanjing University

Nanjing Medical University

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Cryo-shocked cancer cells for targeted drug delivery and vaccination

Science Advances (2020)

Tianyuan Ci Hongjun Li Guojun Chen Zejun Wang Jinqiang Wang

Liquid nitrogen–treated tumor cells serve as a drug carrier and cancer vaccine to facilitate chemo-immunotherapy.

Cancer Immunotherapy

Targeted drug delivery

Cancer drugs

10.1126/sciadv.abc3013

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Citations (137)

Adipocytes Encapsulating Telratolimod Recruit and Polarize Tumor-Associated Macrophages for Cancer Immunotherapy

Carolina Digital Repository (University of North Carolina at Chapel Hill) (2023)

Peter Abdou Wen D Ting Liang Guofeng Chen Li H

Cancer Immunotherapy

10.17615/hwpq-kd48

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Citations (0)

Adipocytes as Anticancer Drug Delivery Depot

Matter (2019)

Di Wen Jinqiang Wang George A. Van Den Driessche Qian Chen Yuqi Zhang

Depot

10.1016/j.matt.2019.08.007

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Citations (67)

Advances in engineering local drug delivery systems for cancer immunotherapy

Wiley Interdisciplinary Reviews Nanomedicine and Nanobiotechnology (2020)

Peter Abdou Zejun Wang Qian Chen Amanda Chan Daojia Zhou

Abstract Cancer immunotherapy aims to leverage the immune system to suppress the growth of tumors and to inhibit metastasis. The recent promising clinical outcomes associated with cancer immunotherapy have prompted research and development efforts towards enhancing the efficacy of immune checkpoint blockade, cancer vaccines, cytokine therapy, and adoptive T cell therapy. Advancements in biomaterials, nanomedicine, and micro‐/nano‐technology have facilitated the development of enhanced local delivery systems for cancer immunotherapy, which can enhance treatment efficacy while minimizing toxicity. Furthermore, locally administered cancer therapies that combine immunotherapy with chemotherapy, radiotherapy, or phototherapy have the potential to achieve synergistic antitumor effects. Herein, the latest studies on local delivery systems for cancer immunotherapy are surveyed, with an emphasis on the therapeutic benefits associated with the design of biomaterials and nanomedicines. This article is categorized under: Nanotechnology Approaches to Biology > Nanoscale Systems in Biology Therapeutic Approaches and Drug Discovery > Nanomedicine for Oncologic Disease

Cancer Immunotherapy

Immune checkpoint

Cancer Therapy

10.1002/wnan.1632

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Citations (55)

Bioorthogonal catalytic patch

Nature Nanotechnology (2021)

Zhaowei Chen Hongjun Li Yijie Bian Zejun Wang Guojun Chen

Bioorthogonal Chemistry

Biomolecule

10.1038/s41565-021-00910-7

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Citations (177)

Adipocytes as Anticancer Drug Delivery Depot

Carolina Digital Repository (University of North Carolina at Chapel Hill) (2019)

Di Wen Jingya Wang George A. Van Den Driessche Q. Chen Y. Zhang

Depot

10.17615/qrds-0j88

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Citations (0)

Advances of injectable hydrogel-based scaffolds for cartilage regeneration

Regenerative Biomaterials (2019)

Jiawei Li Guojun Chen Xingquan Xu Peter Abdou Qing Jiang

Articular cartilage is an important load-bearing tissue distributed on the surface of diarthrodial joints. Due to its avascular, aneural and non-lymphatic features, cartilage has limited self-regenerative properties. To date, the utilization of biomaterials to aid in cartilage regeneration, especially through the use of injectable scaffolds, has attracted considerable attention. Various materials, therapeutics and fabrication approaches have emerged with a focus on manipulating the cartilage microenvironment to induce the formation of cartilaginous structures that have similar properties to the native tissues. In particular, the design and fabrication of injectable hydrogel-based scaffolds have advanced in recent years with the aim of enhancing its therapeutic efficacy and improving its ease of administration. This review summarizes recent progress in these efforts, including the structural improvement of scaffolds, network cross-linking techniques and strategies for controlled release, which present new opportunities for the development of injectable scaffolds for cartilage regeneration.

Regenerative Medicine

10.1093/rb/rbz022

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Citations (145)

Adipocytes Encapsulating Telratolimod Recruit and Polarize Tumor‐Associated Macrophages for Cancer Immunotherapy

Advanced Science (2022)

Di Wen Tingxizi Liang Guojun Chen Hongjun Li Zejun Wang

Tumor-associated adipocytes (TAAs) recruit monocytes and promote their differentiation into tumor-associated macrophages (TAMs) that support tumor development. Here, TAAs are engineered to promote the polarization of TAMs to the tumor suppressive M1 phenotype. Telratolimod, a toll-like receptor 7/8 agonist, is loaded into the lipid droplets of adipocytes to be released at the tumor site upon tumor cell-triggered lipolysis. Locally administered drug-loaded adipocytes increased tumor suppressive M1 macrophages in both primary and distant tumors and suppressed tumor growth in a melanoma model. Furthermore, drug-loaded adipocytes improved CD8+ T cell-mediated immune responses within the tumor microenvironment and favored dendritic cell maturation in the tumor draining lymph nodes.

Cancer Immunotherapy

10.1002/advs.202206001

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Citations (21)

Advances in Engineering Cells for Cancer Immunotherapy

Theranostics (2019)

Xiao Xu Teng Li Shiyang Shen Jinqiang Wang Peter Abdou

Cancer immunotherapy aims to utilize the host immune system to kill cancer cells. Recent representative immunotherapies include T-cell transfer therapies, such as chimeric antigen receptor T cell therapy, antibody-based immunomodulator therapies, such as immune checkpoint blockade therapy, and cytokine therapies. Recently developed therapies leveraging engineered cells for immunotherapy against cancers have been reported to enhance antitumor efficacy while reducing side effects. Such therapies range from biologically, chemically and physically -engineered cells to bioinspired and biomimetic nanomedicines. In this review, advances of engineering cells for cancer immunotherapy are summarized, and prospects of this field are discussed.

Cancer Immunotherapy

Cell therapy

Immune checkpoint

10.7150/thno.38583

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Citations (49)