Anna Kotulska

Medical University of Silesia

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Eugeniusz J. Kucharz

University of Silesia in Katowice

Magdalena Kopeć-Mędrek

Medical University of Silesia

Małgorzata Widuchowska

Medical University of Silesia

G Jonderko

Medical University of Silesia

Ligia Brzeźińska-Wcisło

Medical University of Silesia

M Kopeć

Physique et Mécanique des Milieux Hétérogènes

Piotr Wiland

Wroclaw Medical University

Aleksandra Zoń‐Giebel

Wojewódzki Szpital Specjalistyczny nr 4 w Bytomiu

Robert Pieczyrak

Medical University of Silesia

Maria Majdan

Medical University of Lublin

Cooperative Institutions

Center for Rheumatology

Medical University of Silesia

University of Milan

Górnośląskie Centrum Medyczne

University of Belgrade

University of Silesia in Katowice

University of Zurich

Université Paris Cité

Istituti di Ricovero e Cura a Carattere Scientifico

Poznan University of Medical Sciences

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REVIEW PAPER Sarcoidosis

Reumatologia/Rheumatology (2005)

Katarzyna Jankiewicz-Ziobro Michał Banaś Anna Kotulska Eugeniusz J. Kucharz

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Satisfaction and discontent of Polish patients with biological therapy of rheumatic diseases: results of a multi-center questionnaire study

Reumatologia/Rheumatology (2018)

Anna Kotulska Eugeniusz J. Kucharz Piotr Wiland Marzena Olesińska Anna Felis-Giemza

Objectives Biologics are medications widely applied in the management of inflammatory rheumatic diseases. The drugs were found to be effective but their application is associated with some disadvantages. Medication with biologics is relatively expensive, and in Poland, it is carried out in specialized centers. The study was designed to evaluate various aspects of satisfaction and dissatisfaction of Polish patients treated with biologics. Material and methods An anonymous questionnaire was distributed in 23 Polish rheumatological centers involved in the treatment; 1212 returned questionnaires were used for analysis. Responses were received from 606 patients with rheumatoid arthritis, 427 with ankylosing spondylitis, 117 psoriatic arthritis, and 62 adult patients with juvenile idiopathic arthritis (in whom administration of the drugs had been introduced before they were 18 years old). The investigated group constituted about one-fifth of all rheumatic patients on biologics in Poland. Results A beneficial or very beneficial influence of the medication on the state of physical health was found mostly in patients with rheumatoid arthritis (51.3 and 30.5%) and ankylosing spondylitis (51.0 and 36.8%). Family life was improved by the treatment especially in patients with ankylosing spondylitis (40.7 and 35.6% beneficial and very beneficial, respectively), sleep quality and sexual life mostly in those with ankylosing spondylitis (beneficial/very beneficial influence 41.5/38.4, and 38.7/23.9, respectively). There was a rather small influence of biological treatment on the financial situation of the patients. In general, satisfaction with the treatment was evaluated as positive or very positive in 88% of all investigated patients. In a significant part of the patients, transportation to the medical center was considered as a disadvantage of the treatment. About one-third of the patients considered laboratory and imaging tests to be done before initiation of the medication as a difficulty, and for about 40% waiting time for qualification for the medication was a significant disadvantage. The route of drug administration was without importance for 4/5 of the patients. Conclusions Summing up, the results were similar in the patients suffering from various diseases although those with psoriatic arthritis felt the highest satisfaction (possibly due to the positive aesthetic effect), and those with ankylosing spondylitis had significant improvement in sexual life (probably due to younger age). Relatively low satisfaction was found in patients with juvenile idiopathic arthritis. There was a small influence of medication on financial status of the patients. Application of biologics has few disadvantages and most of them are associated with the organization of health services (waiting time for the tests, transportation to the medical centers).

Spondylitis

10.5114/reum.2018.76901

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Carpal tunnel syndrome as the early symptom of rapidly progressive systemic sclerosis in men.

Małgorzata Widuchowska Anna Kotulska Magdalena Kopeć-Mędrek Eugeniusz J. Kucharz

Progressive systemic sclerosis

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Śluzak serca jako przyczyna rzekomego zapalenia naczyń. Opis przypadku

Aleksandra Zoń‐Giebel Anna Kotulska Eugeniusz J. Kucharz

Summary A case of cardiac myxoma with several signs and symptoms of systemic vasculitis (livedo reticularis, weakness, arthralgia, slight fever, anaemia, enhanced erythrocyte sedimentation rate) was reported. Surgical removal of the myxoma from the left atrium of the heart resulted in complete resolution of the symptoms and signs. The diagnosis of pseudovasculitis caused by cardiac myxoma was made.

Livedo reticularis

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Fungicide methfuroxan administered chronically to rats did not affect serum thyroid hormone levels.

PubMed (1995)

Kenji Kita G Jonderko Kucharz Ej Anna Kotulska T Gołab

Intoxication of adult rats with fungicide methfuroxan (2,4,5-trimethyl-N-phenyl 1,3-furancarboxamid, C 14 H 15 NO 2 ) in a dose of 20 or 100 mg/kg of fodder for 24 months was shown to have no influence upon serum level of thyroid hormones.

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Fodder

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Application of etanercept in treatment of juvenile idiopathic arthritis and adult onset still disease

Maciej Lewicki Anna Kotulska Eugeniusz J. Kucharz

Adult-onset Still's disease

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Fever of unknown origin

Katarzyna Jankiewicz-Ziobro Maciej Lewicki Anna Kotulska Eugeniusz J. Kucharz

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[Effect of long-term exposure to high manganese levels in the air of the work area on the content of various immunoproteins in the blood].

PubMed (1986)

G Jonderko E Tyrna J Pietrzak Anna Kotulska

Fifty-four subjects chronically exposed to high manganese concentrations due to professional melting of iron-manganese alloys have been examined. The threshold limit value was exceeded 3 to 4-fold. The minimum length of employment in exposure was 5 years, whereas the average-17.7 years. Control groups were matched by age, length of employment and energy expense. Among the determined parameters, i.e. IgG, IgA, IgM concentrations in blood serum and C3 and C4 elements of the complement--only the IgM concentration was significantly lower, whereas the others were not significantly different from those in relevant control groups.

Threshold limit value

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LIST DO REDAKCJI/LETTER TO THE EDITOR Etiology of enhanced body temperature in patients admitted due to fever of unknown origin: analysis of 100 consecutive cases

Reumatologia/Rheumatology (2005)

Aneta Franczak-Drygalska Katarzyna Jankiewicz-Ziobro Anna Kotulska Eugeniusz J. Kucharz

Etiology

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Tumor necrosis factor associated periodic syndrome in a family from Silesia