From 1975 to 1989, 12 patients with pemphigus vulgaris (PV) and 19 with pemphigus foliaceus (PF) were treated with systemic or topical corticosteroids at the Nara University Hospital. All 12 patients with PV were treated with oral corticosteroids (initial dose of prednisolone: 15-70 mg/day) and 4 of 12 patients showed prolonged clinical remission (up to 9 years) without corticosteroids. Of 19 patients with PF, 16 patients were treated with oral corticosteroids (initial dose of prednisolone: 8-40 mg/day) and 3 patients were treated with only topical application of corticosteroids. In PF, 7 of 16 patients treated with systemic corticosteroids and all 3 patients treated with topical corticosteroids also showed prolonged clinical remission (up to 10 years). These observations suggest that most of the patients with pemphigus respond well to the treatment of relatively small or moderate dosage of corticosteroids.

Prednisolone

Pemphigus vulgaris

Pemphigus foliaceus

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Citations (1)

A Case of Angiosarcoma of the Nose

The Journal of Dermatology (2002)

Yoko Nishiwaki Yurie Tada Chie Nakatani Yukio Yamashina Toshihiko Shirai

Abstract A case of angiosarcoma arising from the nose of a 69‐year‐old man is presented in this report. The patient was treated with a combination of recombinant interleukin‐2 (rIL‐2, Celeuk®), electron beam irradiation, and surgery. He died 27 months after diagnosis, but there was no apparent remote metastasis.

10.1111/j.1346-8138.2002.tb00185.x

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Citations (7)

Pemphigus Vulgaris Preceded by Herpetiform‐like Skin Lesions with Negative Immunofluorescence Findings

The Journal of Dermatology (1999)

Tsutomu Muramatsu Takashi Iida Kumiko Honoki Chie Nakatani Mitsuo Hatoko

Abstract We report a case of pemphigus vulgaris in a 63‐year‐old woman. At the first onset, she developed herpetiform‐like skin lesions. Their histology showed eosinophilic spongiosis and intraepidermal blister formation with an infiltrate of eosinophils. Both direct and indirect immunofluorescence studies were negative. She remained in remission for 6 years. At the second onset, she developed bullous skin lesions; histological examination disclosed suprabasal acantholysis and infiltration of eosinophils. Direct immunofluorescence revealed IgG and C3 deposits at the cell surface, predominantly in the lower epidermis. Indirect immunofluorescence using normal human skin as a substrate demonstrated anti‐cell surface IgG antibodies at a titer of 1:160. Immunoblot analysis showed that the patient's serum reacted only with a 130kD protein. This case indicates that pemphigus vulgaris can follow herpetiform‐like skin lesions with negative immunofluorescence findings after a long remission time.

Pemphigus vulgaris

Acantholysis

Immunofluorescence

Direct fluorescent antibody

Spongiosis

10.1111/j.1346-8138.1999.tb03446.x

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Citations (10)

050 Disappearance of α 3 β 4 integrin in the lesional skin of the patients with bullous pemphigoid with circulating antibodies against BP180 and/or BP230

Journal of Dermatological Science (1997)

T. lida Tuyoshi MURAMATU Chie Nakatani Tsuyoshi Shirai

10.1016/s0923-1811(97)81754-9