Mary Jefferson

Tulane University

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David Easley

Scott & White Memorial Hospital

Frank J. Accurso

University of Colorado Anschutz Medical Campus

Leland V. Miller

University of Colorado Denver

K. Michael Hambidge

University of Colorado Denver

Jamie Erskine

University of Northern Colorado

Nancy F. Krebs

University of Colorado Denver

Muriel Kelemen

George Washington University

Stephanie Tortu

Louisiana State University

Uday Patel

Second Sight Medical Products

A Becker

Lurie Children's Hospital

Cooperative Institutions

George Washington University

University of Colorado Denver

United States Department of Veterans Affairs

Children's Hospital Colorado

University of Colorado Anschutz Medical Campus

Houston Health and Human Services Department

Centers for Disease Control and Prevention

Louisiana State University

Louisiana State University Health Sciences Center New Orleans

Veterans Health Administration

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Ultrastructure of fetal spinal cord and cortex implants into adult rat spinal cord

Journal of Neuroscience Research (1984)

J. J. Bernstein Uday Patel Muriel Kelemen Mary Jefferson Steven Turtil

The ultrastructure of cortex and spinal cord from 11-, 12-, and 15-day-old fetuses implanted into the spinal cord of adult rats was studied over 3 months. Under deep Chloropent anesthesia, a 0.5 X 1.0-mm square of fetal cortex or a 1.0-mm segment of fetal spinal cord was implanted subpially between the left dorsal column and the dorsal horn of 70 adult rats. Implants grew toward gray matter, usually interfacing with the host at the isthmus between the horns of the spinal cord. However, implants were observed that occupied the entire left dorsal and ventral horns of the left half of the host spinal cord. Implants had concentric zones: A central zone with basal lamina lined joined channels and subjacent neuroglia; a zone of differentiating implant nervous system; a zone with basal lamina lined implant with overlying pial cells on the dorsal and lateral surfaces of the implant; a zone that interfaced with the host with overlapping neuropil on the lateral and ventral surfaces of the implant. Neuron types were typical for cortical or spinal implants. Implants survived for 3 months and reached stages of neuronal and neuroglial maturation similar to controls. Both fetal spinal cord and brain were successful as implants, had delayed differentiation, and formed complex neuropils. The zone of overlapping interface of the donor and host is an anatomical indication of physiological and functional integration.

Neuropil

Lamina

10.1002/jnr.490110404

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Citations (39)

Recruiting Injection Drug Users: A Three-Site Comparison of Results and Experiences with Respondent-Driven and Targeted Sampling Procedures

Journal of Urban Health (2006)

William T. Robinson Jan Risser Shanell L. McGoy A Becker Hafeez Ur Rehman

Several recent studies have utilized respondent-driven sampling (RDS) methods to survey hidden populations such as commercial sex-workers, men who have sex with men (MSM) and injection drug users (IDU). Few studies, however, have provided a direct comparison between RDS and other more traditional sampling methods such as venue-based, targeted or time/space sampling. The current study sampled injection drug users in three U.S. cities using RDS and targeted sampling (TS) methods and compared their effectiveness in terms of recruitment efficiency, logistics, and sample demographics. Both methods performed satisfactorily. The targeted method required more staff time per-recruited respondent and had a lower proportion of screened respondents who were eligible than RDS, while RDS respondents were offered higher incentives for participation.

Demographics

Sample (material)

10.1007/s11524-006-9100-3

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Citations (119)

Effect of Pancreatic Enzymes on Zinc Absorption in Cystic Fibrosis

Journal of Pediatric Gastroenterology and Nutrition (1998)

David Easley Nancy F. Krebs Mary Jefferson Leland V. Miller Jamie Erskine

The trace metal zinc has a wide range of important physiologic roles. Indirect evidence suggests that fat malabsorption is associated with malabsorption of zinc. The objective of this study was to evaluate the effect of pancreatic enzyme replacement on zinc absorption in children and adolescents with cystic fibrosis.Subjects were four boys and four girls ranging in age from 7 to 17 years of age. All were pancreatic insufficient. Stable isotope labels, 70Zn and 67Zn, were administered orally in divided doses on consecutive days with meals. Meals were identical on the first 2 study days. Subjects were randomized to have pancreatic enzyme replacement withheld on the first or second day. All fecal samples were collected quantitatively for 10 days after label administration and were analyzed individually for total zinc and isotopic enrichment using atomic absorption spectrophotometry and fast atom bombardment mass spectrometry, respectively. Fractional absorption of zinc was calculated from cumulative fecal excretion of unabsorbed label.Fractional absorption while receiving enzymes was 0.50 +/- 0.29 versus 0.38 +/- 0.24 while not taking enzymes (p = 0.05).These results indicate that fractional absorption of zinc is impaired by pancreatic insufficiency in patients with cystic fibrosis, and is improved by exocrine pancreatic enzyme replacement.

Pancreatic enzymes

Pancreatic Disease

10.1097/00005176-199802000-00003

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Citations (50)

Astrocytes secrete basal lamina after hemisection of rat spinal cord

Brain Research (1985)

Jerald J. Bernstein Reina Getz Mary Jefferson Muriel Kelemen

Lamina lucida

Neuroglia

Lamina

Basal (medicine)

10.1016/0006-8993(85)91507-0

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Citations (160)

Effect of Pancreatic Enzymes on Zinc Absorption in Cystic Fibrosis

Journal of Pediatric Gastroenterology and Nutrition (1998)

David Easley Nancy F. Krebs Mary Jefferson Leland V. Miller Jamie Erskine

ABSTRACT Background: The trace metal zinc has a wide range of important physiologic roles. Indirect evidence suggests that fat malabsorption is associated with malabsorption of zinc. The objective of this study was to evaluate the effect of pancreatic enzyme replacement on zinc absorption in children and adolescents with cystic fibrosis. Methods: Subjects were four boys and four girls ranging in age from 7 to 17 years of age. All were pancreatic insufficient. Stable isotope labels, 70 Zn and 67 Zn, were administered orally in divided doses on consecutive days with meals. Meals were identical on the first 2 study days. Subjects were randomized to have pancreatic enzyme replacement withheld on the first or second day. All fecal samples were collected quantitatively for 10 days after label administration and were analyzed individually for total zinc and isotopic enrichment using atomic absorption spectrophotometry and fast atom bombardment mass spectrometry, respectively. Fractional absorption of zinc was calculated from cumulative fecal excretion of unabsorbed label. Results: Fractional absorption while receiving enzymes was 0.50 ± 0.29 versus 0.38 ± 0.24 while not taking enzymes ( p = 0.05). Conclusions: These results indicate that fractional absorption of zinc is impaired by pancreatic insufficiency in patients with cystic fibrosis, and is improved by exocrine pancreatic enzyme replacement.

Pancreatic enzymes

Pancreatic Disease

10.1002/j.1536-4801.1998.tb00741.x

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Citations (4)