Changshun Chen

Yunnan University

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Chenhui Yang

Gansu Great Wall Electrical and Electronics Engineering Research Institute

Rongjin Chen

Lanzhou University

Ge Chen

Ocean University of China

Yayi Xia

Lanzhou University Second Hospital

Hefang Xiao

Lanzhou University Second Hospital

Pu He

Lanzhou University

Jinyi Gu

Yunnan University

Yunjie Du

Lanzhou University

Bin Geng

Lanzhou University

Bingdong Zhu

Lanzhou University

Cooperative Institutions

Lanzhou University

Lanzhou University Second Hospital

Yunnan University

Peking University

Hohai University

Gansu Great Wall Electrical and Electronics Engineering Research Institute

Huazhong University of Science and Technology

Ministry of Ecology and Environment

Max Planck Institute for Metabolism Research

Zhengzhou City Hospital

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Effectiveness of indomethacin in preventing Heterotopic Ossification: a systematic review and meta-analysis of randomized controlled trials

Journal of Orthopaedic Surgery and Research (2024)

Lei Wen Changshun Chen Yongcheng Deng Ge Chen

10.1186/s13018-024-05086-z

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TRPV Channels in Osteoarthritis: A Comprehensive Review

Biomolecules (2024)

Changshun Chen Fei Yang Rongjin Chen Chenhui Yang Hefang Xiao

Osteoarthritis (OA) is a debilitating joint disorder that affects millions of people worldwide. Despite its prevalence, our understanding of the underlying mechanisms remains incomplete. In recent years, transient receptor potential vanilloid (TRPV) channels have emerged as key players in OA pathogenesis. This review provides an in-depth exploration of the role of the TRPV pathway in OA, encompassing its involvement in pain perception, inflammation, and mechanotransduction. Furthermore, we discuss the latest research findings, potential therapeutic strategies, and future directions in the field, shedding light on the multifaceted nature of TRPV channels in OA.

TRPV

Mechanotransduction

10.3390/biom14030292

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Unraveling the Immune Regulatory Functions of USP5: Implications for Disease Therapy

Biomolecules (2024)

Jinyi Gu Changshun Chen Pu He Yunjie Du Bingdong Zhu

Ubiquitin-specific protease 5 (USP5) belongs to the ubiquitin-specific protease (USP) family, which uniquely recognizes unanchored polyubiquitin chains to maintain the homeostasis of monoubiquitin chains. USP5 participates in a wide range of cellular processes by specifically cleaving isopeptide bonds between ubiquitin and substrate proteins or ubiquitin itself. In the process of immune regulation, USP5 affects important cellular signaling pathways, such as NF-κB, Wnt/β-catenin, and IFN, by regulating ubiquitin-dependent protein degradation. These pathways play important roles in immune regulation and inflammatory responses. In addition, USP5 regulates the activity and function of immunomodulatory signaling pathways via the deubiquitination of key proteins, thereby affecting the activity of immune cells and the regulation of immune responses. In the present review, the structure and function of USP5, its role in immune regulation, and the mechanism by which USP5 affects the development of diseases by regulating immune signaling pathways are comprehensively overviewed. In addition, we also introduce the latest research progress of targeting USP5 in the treatment of related diseases, calling for an interdisciplinary approach to explore the therapeutic potential of targeting USP5 in immune regulation.

Deubiquitinating enzyme

10.3390/biom14060683

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