Lucas Sousa Magalhães

Universidade Federal de Sergipe

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Amélia Ribeiro de Jesus

Universidade Federal de Sergipe

Roque Pacheco de Almeida

Universidade Federal de Sergipe

Camilla Natália Oliveira Santos

Universidade Federal de Sergipe

Priscila Lima dos Santos

Universidade Federal de Sergipe

Michael W. Lipscomb

University of Minnesota

Tatiana Rodrigues de Moura

Universidade Federal de Sergipe

ÂM

Ângela Maria da Silva

Universidade Federal de Sergipe

Rodrigo Anselmo Cazzaniga

Universidade Federal de Sergipe

Juliana Cardoso Alves

Universidade Federal de Sergipe

Lays Gisele Santos Bomfim

Universidade Federal de Sergipe

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Universidade Federal de Sergipe

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Universidade Tiradentes

Universidade de São Paulo

Fundação Oswaldo Cruz

Universidade Federal da Bahia

National Council for Scientific and Technological Development

Universidade Federal de Minas Gerais

Universidade de Ribeirão Preto

Instituto de Tecnologia e Pesquisa

Hospital Ana Nery

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Inflammatory modulation of fluoxetine use in patients with depression: A systematic review and meta-analysis

Cytokine (2020)

Isabella Barros Almeida Isla Alcântara Gomes S. Saravanan Tatiana Rodrigues de Moura Lucas Sousa Magalhães

Proinflammatory cytokine

Depression

Forest plot

10.1016/j.cyto.2020.155100

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Citations (27)

Influence of Testosterone in Neglected Tropical Diseases: Clinical Aspects in Leprosy and In Vitro Experiments in Leishmaniasis

Tropical Medicine and Infectious Disease (2023)

Laís Lima de Oliveira Rekowsky Daniela Teles de Oliveira Rodrigo Anselmo Cazzaniga Lucas Sousa Magalhães Lenise Franco Albuquerque

Neglected tropical diseases encompass a group of chronic and debilitating infectious diseases that primarily affect marginalized populations. Among these diseases, leprosy and leishmaniasis are endemic in numerous countries and can result in severe and disfiguring manifestations. Although there have been reports indicating a higher incidence of leprosy and leishmaniasis in males, the underlying factors contributing to this observation remain unclear. Therefore, the objective of this study was to examine both clinical and experimental evidence regarding the role of testosterone in leprosy and leishmaniasis. A prospective clinical study was conducted to compare the clinical forms of leprosy and assess circulating testosterone levels. Additionally, the impact of testosterone on Leishmania amazonensis-infected macrophages was evaluated in vitro. The findings demonstrated that serum testosterone levels were higher in women with leprosy than in the control group, irrespective of the multi- or pauci-bacillary form of the disease. However, no differences in testosterone levels were observed in men when comparing leprosy patients and controls. Interestingly, increasing doses of testosterone in macrophages infected with L. amazonensis resulted in a higher proportion of infected cells, decreased CD40 expression on the cell surface, elevated expression of SOCS1, and decreased expression of IRF5. These findings provide biological evidence to support the influence of testosterone on intracellular infections, though the interpretation of clinical evidence remains limited.

10.3390/tropicalmed8070357

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Citations (1)

Association of IL-9, IL-10, and IL-17 Cytokines With Hepatic Fibrosis in Human Schistosoma mansoni Infection

Frontiers in Immunology (2021)

Karine Garcez Schuster Franco Fábio Jorge Ramalho de Amorim Mário Adriano Santos Carla Virgínia Vieira Rollemberg Fabrícia Alvisi de Oliveira

This is a case series study to evaluate immunological markers associated with schistosomiasis advanced fibrosis, including 69 patients from an endemic area from the State of Sergipe and from the Hepatology Service of the University Hospital in Sergipe, Brazil. Hepatic fibrosis was classified based on Niamey protocol for ultrasonography (US). Immune response to Schistosoma mansoni antigens was evaluated by stimulating peripheral blood mononuclear cells (PBMCs) from these patients with either adult worm (SWAP—10 μg/ml) or egg (SEA—10 μg/ml) antigens or purified protein derivative of turberculin (PPD—10 μg/ml) or phytohemagglutinin (PHA—1 μg/ml) for 72 h. The levels of IFN-γ, TNF-α, IL-5, IL-10, and IL-17 were measured in these supernatants by ELISA and IL-9 by Luminex. Single nucleotide polymorphisms in IL-17 , IL10 , and CD209 genes were genotyped using TaqMan probe by qPCR. Higher levels of IL-9, IL-10, and IL-17 were found in PBMC supernatants of patients with advanced hepatic fibrosis. Direct correlations were detected between IL-9 and IL-17 levels with US spleen sizes, portal vein diameters, and periportal thickening. The CD209 rs2287886 AG polymorphism patients produce higher IL-17 levels. Together, these data suggest a role of these cytokines in the immunopathogenesis of advanced fibrosis in human schistosomiasis.

Schistosoma

Hepatic fibrosis

10.3389/fimmu.2021.779534

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Citations (14)

base_homicidio.xlsx

Harvard Dataverse (2020)

Lucas Sousa Magalhães

Base contendo as taxas de homicídio por 100 mil habitantes do Estado de São Paulo

Base (topology)

10.7910/dvn/tcyteo/eha8l1

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Citations (0)

sp_idhm.tab

Harvard Dataverse (2020)

Lucas Sousa Magalhães

Base contendo o idhm dos municípios do Estado de São Paulo

10.7910/dvn/tcyteo/ltllrn

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Increased thiol levels in antimony-resistant Leishmania infantum isolated from treatment-refractory visceral leishmaniasis in Brazil

Memórias do Instituto Oswaldo Cruz (2017)

Lucas Sousa Magalhães Lays GS Bomfim Sthefanne G Mota Geydson Silveira da Cruz Cristiane Bani Corrêa

BACKGROUND Treatment-refractory visceral leishmaniasis (VL) has become an important problem in many countries. OBJECTIVES We evaluated the antimony-resistance mechanisms of Leishmania infantum isolated from VL patients refractory or responsive to treatment with pentavalent antimony. METHODS Strains isolated from antimony-refractory patients (in vitro antimony-resistant isolates) and antimony-responsive patients (in vitro antimony-sensitive isolates) were examined. Morphological changes were evaluated by transmission electron microscopy after trivalent antimony exposure. P-glycoprotein (P-gp) efflux pump activity was evaluated using the pump-specific inhibitor verapamil hydrochloride, and the role of thiol in trivalent antimony resistance was investigated using the enzymatic inhibitor L-buthionine sulfoximine. FINDINGS Antimony treatment induced fewer alterations in the cellular structure of L. infantum resistant isolates than in that of sensitive isolates. P-gp efflux activity was not involved in antimony resistance in these isolates. Importantly, the resistant isolates contained higher levels of thiol compared to the sensitive isolates, and inhibition of thiol synthesis in the resistant isolates recovered their sensitivity to trivalent antimony treatment, and enhanced the production of reactive oxygen species in promastigotes exposed to the drug. MAIN CONCLUSIONS Our results demonstrate that isolates from patients with antimony-refractory VL exhibited higher thiol levels than antimony-sensitive isolates. This indicates that redox metabolism plays an important role in the antimony-resistance of New World VL isolates.

Efflux

Thiol

Meglumine antimoniate

Refractory (planetary science)

10.1590/0074-02760170289

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Citations (13)

Coinfection with chikungunya and Zika results in mild disease and distinct inflammatory response

npj Viruses (2025)

Juliana Cardoso Alves Lucas Sousa Magalhães Priscila Lima dos Santos Regina Adalva de Lucena Couto Ócea Alejandra Debbo

Abstract Chikungunya (CHIKV) and Zika (ZIKV) viruses, both mosquito-borne, often circulate simultaneously, raising concerns about the effects of coinfection. This study evaluated cytokines, chemokines, and growth factors in 12 patients with concurrent CHIKV and ZIKV infections confirmed by RT-qPCR. Clinical data and 45 immune mediators were analyzed. Coinfected and monoinfected patients exhibited similar symptoms, although ZIKV-infected individuals experienced fewer instances of fever. No patients had persistent symptoms or required hospitalization. Chemokines CCL5, CXCL1, and CXCL10 were elevated across all groups. CHIKV-infected patients showed higher levels of CCL2, CCL4, EGF, CXCL12, and IFN-α compared to controls, while IL-1RA, IL-8, and IFN-γ were elevated in both CHIKV and coinfected groups. SCF was elevated only in the ZIKV group. Overall, CHIKV and ZIKV coinfection presented mild clinical symptoms similar to monoinfections and demonstrated a moderate inflammatory response.

Zika Virus

10.1038/s44298-025-00098-w

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Preferências políticas importam? Uma análise das sentenças criminais proferidas pelos Juízes do Estado de São Paulo

Harvard Dataverse (2020)

Lucas Sousa Magalhães

Base de dados original contendo 487.664 decisões judiciais proferidas por Juízes de 1º Grau do Estado de São Paulo no período de 2013 a 2019

10.7910/dvn/tcyteo

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PRINCIPAIS TÉCNICAS MOLECULARES UTILIZADAS PARA VERIFICAR A COMPATIBILIDADE HLA ENTRE DOADOR E RECEPTOR NO TRANSPLANTE DE RINS PROVENIENTES DE DOADOR FALECIDO: UMA REVISÃO