Ning‐Hung Chen

Chang Gung University

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Li‐Pang Chuang

Chang Gung Memorial Hospital

Hsueh‐Yu Li

Chang Gung University

Shih‐Wei Lin

Chang Gung Memorial Hospital

Kuo‐Chin Kao

Chang Gung University

Li‐Ang Lee

Chang Gung Memorial Hospital

Chung-Chi Huang

Chang Gung University

Cheng‐Ta Yang

Chang Gung Memorial Hospital

Han‐Chung Hu

Chang Gung Memorial Hospital

Pa‐Chun Wang

Fu Jen Catholic University

Li‐Fu Li

Chang Gung Memorial Hospital

Cooperative Institutions

Chang Gung Memorial Hospital

265

Chang Gung University

249

Linkou Chang Gung Memorial Hospital

158

Memorial Hospital of South Bend

142

University Hospital of Basel

National Yang Ming Chiao Tung University

National Taiwan University

Taoyuan Chang Gung Memorial Hospital

Chang Gung University of Science and Technology

Taipei Medical University

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Author Response: Association of Sleep, Neuropsychological Performance, and Gray Matter Volume With Glymphatic Function in Community-Dwelling Older Adults

Neurology (2023)

Tiing Yee Siow Cheng‐Hong Toh Jung‐Lung Hsu Geng-Hao Liu Shwu‐Hua Lee

We appreciate the insightful comments on our study.1 Contrast-based imaging allows direct visualization of the glymphatic system and assessment of its function based on the pharmacokinetics of contrast agents. However, quantifications of glymphatic activity in individual fluid compartments may require other techniques.

Glymphatic System

Association (psychology)

10.1212/wnl.0000000000206875

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Attention-deficit/hyperactivity disorder with obstructive sleep apnea: A treatment outcome study

Sleep Medicine (2006)

Yu‐Shu Huang Christian Guilleminault Hsueh‐Yu Li Chien‐Ming Yang Yu‐Yu Wu

CBCL

Neurocognitive

Child Behavior Checklist

10.1016/j.sleep.2006.05.016

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Citations (195)

Pulmonary Tuberculosis-Related Acute Respiratory Distress Syndrome in a Healthy Adult Rescued by Extracorporeal Membrane Oxygenation- A Case Report and Literature Review

胸腔醫學 (2016)

Cheng–Hsin Chen Kuo‐Chin Kao Ning‐Hung Chen Chung-Chi Huang Hen-I Lin

Pulmonary tuberculosis (TB) has rarely been recognized as an etiologic agent of acute respiratory distress syndrome (ARDS). In this case report, we describe a previously healthy 36-year-old female who developed severe ARDS caused by pulmonary TB. Pulmonary TB was confirmed by positive acid-fast stain and TB sputum culture results; other microbiological etiologies showed negative findings. In addition to treatment with anti-TB agents, veno-venous mode extracorporeal membrane oxygenation was performed owing to progressive severe oxygenation failure under conventional mechanical ventilation. Despite aggressive treatment in the intensive care unit, the patient's condition deteriorated and she died as a result ofseptic shock and multiple organ failure. This case report demonstrated that pulmonary TB should not be ignored as a possible cause of ARDS, in order to avoid the adverse consequences of delayed diagnosis or missed treatment, especially in an endemic area.

Etiology

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Recovery of pulmonary functions, exercise capacity, and quality of life after pulmonary rehabilitation in survivors of ARDS due to severe influenza A (H1N1) pneumonitis

Influenza and Other Respiratory Viruses (2018)

Meng‐Jer Hsieh Wei‐Chun Lee Hsiu‐Ying Cho Meng‐Fang Wu Han‐Chung Hu

Background Acute respiratory distress syndrome ( ARDS ) due to severe influenza A H1N1 pneumonitis would result in impaired pulmonary functions and health‐related quality of life ( HRQ oL) after hospital discharge. Objectives The recovery of pulmonary functions, exercise capacity, and HRQ oL in the survivors of ARDS due to 2009 pandemic influenza A H1N1 pneumonitis (H1N1‐ ARDS ) was evaluated in a tertiary teaching hospital in northern Taiwan between May 2010 and June 2011. Patients and Methods Data of spirometry, total lung capacity ( TLC ), diffusing capacity of carbon monoxide ( DL CO ), and 6‐minute walk distance (6 MWD ) in the patients survived from H1N1‐ ARDS were collected 1, 3, and 6 months post‐hospital discharge. HRQ oL was evaluated with St. George respiratory questionnaire ( SGRQ ). Results Nine survivors of H1N1‐ ARDS in the study period were included. All these patients received 2 months’ pulmonary rehabilitation program. Pulmonary functions and exercise capacity included TLC , forced vital capacity ( FVC ), forced expiratory volume in the first second ( FEV 1 ), DL CO , and 6 MWD improved from 1 to 3 months post‐hospital discharge. Only TLC had further significant improvement from 3 to 6 months. HRQ oL represented as the total score of SGRQ had no significant improvement in the first 3 months but improved significantly from 3 to 6 months post‐discharge. Conclusion The impaired pulmonary functions and exercise capacity in the survivors of H1N1‐ ARDS improved soon at 3 months after hospital discharge. Their quality of life had keeping improved at 6 months even though there was no further improvement of their pulmonary functions and exercise capacity.

Vital capacity

10.1111/irv.12566

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Citations (98)

Airway distensibility: Bringing physiology to the bedside – Reply

Respirology (2019)

Ning‐Hung Chen Shih‐Wei Lin Li‐Pang Chuang

See Letter

Respiratory physiology

10.1111/resp.13548

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Trajectories of Sleep and Its Predictors in the First Year Following Traumatic Brain Injury

Journal of Head Trauma Rehabilitation (2014)

Pin-Yuan Chen Pei-Shan Tsai Ning‐Hung Chen Li-Pang Chaung Cheng‐Chi Lee

Objectives: To examine how sleep patterns change over the first year following traumatic brain injury (TBI) and to determine whether specific demographic and disease characteristics predict the trajectories of sleep. Design: Prospective study. Participants: Fifty-three patients with first-ever mild to severe TBI. Main Measurements: Sleep measured by actigraphy for 7 consecutive days in the first, third, sixth, and twelfth months following TBI: Chinese versions of Beck Anxiety Inventory and Beck Depression Inventory-II (CBDI-II) measured at the same time points. Data were analyzed with a linear mixed model. Results: Sleep efficiency (the ratio of sleep time to the total time spent in bed) showed a significant upward trend during the study period. Scores on the Chinese version of the Beck Anxiety Inventory and the CBDI-II as well as the use of analgesics significantly predicted the slope of change in sleep efficiency over time. Conclusions: Poor sleep efficiency is a common symptom in the first year among patients with first-ever TBI. Healthcare providers should consider both mental health and pain issues when dealing with sleep complaints in patients with TBI.

Beck Anxiety Inventory

Sleep

Depression

10.1097/htr.0000000000000086

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Citations (18)

Role of Changes in Driving Pressure and Mechanical Power in Predicting Mortality in Patients with Acute Respiratory Distress Syndrome

Diagnostics (2023)

Huang-Pin Wu Shaw-Woei Leu Shih‐Wei Lin Chen‐Yiu Hung Ning‐Hung Chen

Driving pressure (ΔP) and mechanical power (MP) are associated with increased mortality in patients with acute respiratory distress syndrome (ARDS). We aimed to investigate which was better to predict mortality between changes in ΔP and MP. We reanalyzed data from a prospective observational cohort study of patients with ARDS in our hospital. Serial ΔP and MP values were calculated. The factors associated with survival were analyzed. Binary logistic regression showed that age (odds ratio (OR), 1.012; 95% confidence interval (CI), 1.003-1.022), Sequential Organ Failure assessment (SOFA) score (OR, 1.144; 95% CI, 1.086-1.206), trauma (OR, 0.172; 95% CI, 0.035-0.838), ΔP (OR, 1.077; 95% CI, 1.044-1.111), change in ΔP (OR, 1.087; 95% CI, 1.054-1.120), and change in MP (OR, 1.018; 95% CI, 1.006-1.029) were independently associated with 30-day mortality. Change in MP, change in ΔP, and SOFA scores were superior to ΔP in terms of the accuracy of predicting 30-day mortality. In conclusion, calculating change in ΔP is easy for respiratory therapists in clinical practice and may be used to predict mortality in patients with ARDS.

10.3390/diagnostics13071226

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A Comparison of the Long‐Term Outcome and Effects of Surgery or Continuous Positive Airway Pressure on Patients with Obstructive Sleep Apnea Syndrome

The Laryngoscope (2006)

Shih‐Wei Lin Ning‐Hung Chen Hsueh‐Yu Li Tuan‐Jen Fang Chong‐Chi Huang

Abstract Objectives: To compare the long‐term (3‐year) outcome and effects of continuous positive airway pressure (CPAP) and extended uvulopalatoplasty (EUPF) treatment on patients with obstructive sleep apnea syndrome. Methods: Eighty‐four patients who received CPAP titration and bought a CPAP machine to use from March 2000 to October 2001 were included as the CPAP group. Another 55 patients who underwent EUPF surgery were included as the EUPF group. Overnight polysomnography was performed 6 months and 3 years after CPAP titration or EUPF. The disease‐specific questionnaire‐Snore Outcome Survey (SOS), Epworth Sleepiness Scale (ESS), and the generic health questionnaire‐MOSF‐36 were administered at the 6‐month and 3‐year follow‐up examinations. Results: The age, body mass index, respiratory disturbance index, and ESS before treatment were higher in the CPAP group. The snore index was higher in the surgery group. Fifty‐four patients (64.3%) in CPAP group continued treatment for 6 months; the success rate for EUPF at 6 months was 82%. The polysomnographic variables improved significantly in both groups. Improvements in the SOS and ESS scores were better in surgery group than the CPAP group. The subscales of SF‐36 in surgery group were more than those in CPAP group. Conclusions: EUPF had a better effect on snoring than CPAP 6 months after treatment in patients with obstructive sleep apnea syndrome (OSAS). This effect had gradually declined at the 3‐year follow‐up examination. Improvement in the quality of life of OSAS patients receiving EUPF is equal to those receiving CPAP treatment.

Respiratory disturbance index

Epworth Sleepiness Scale

Positive airway pressure

10.1097/01.mlg.0000217242.16814.da

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Citations (20)

Ethyl pyruvate attenuates ventilation‐induced diaphragm dysfunction through high‐mobility group box‐1 in a murine endotoxaemia model

Journal of Cellular and Molecular Medicine (2019)

Yung‐Yang Liu Ning‐Hung Chen Chih‐Hao Chang Shih‐Wei Lin Kuo‐Chin Kao

Mechanical ventilation (MV) can save the lives of patients with sepsis. However, MV in both animal and human studies has resulted in ventilator-induced diaphragm dysfunction (VIDD). Sepsis may promote skeletal muscle atrophy in critically ill patients. Elevated high-mobility group box-1 (HMGB1) levels are associated with patients requiring long-term MV. Ethyl pyruvate (EP) has been demonstrated to lengthen survival in patients with severe sepsis. We hypothesized that the administration of HMGB1 inhibitor EP or anti-HMGB1 antibody could attenuate sepsis-exacerbated VIDD by repressing HMGB1 signalling. Male C57BL/6 mice with or without endotoxaemia were exposed to MV (10 mL/kg) for 8 hours after administrating either 100 mg/kg of EP or 100 mg/kg of anti-HMGB1 antibody. Mice exposed to MV with endotoxaemia experienced augmented VIDD, as indicated by elevated proteolytic, apoptotic and autophagic parameters. Additionally, disarrayed myofibrils and disrupted mitochondrial ultrastructures, as well as increased HMGB1 mRNA and protein expression, and plasminogen activator inhibitor-1 protein, oxidative stress, autophagosomes and myonuclear apoptosis were also observed. However, MV suppressed mitochondrial cytochrome C and diaphragm contractility in mice with endotoxaemia (P < 0.05). These deleterious effects were alleviated by pharmacologic inhibition with EP or anti-HMGB1 antibody (P < 0.05). Our data suggest that EP attenuates endotoxin-enhanced VIDD by inhibiting HMGB1 signalling pathway.

Diaphragm (acoustics)

10.1111/jcmm.14478

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Citations (8)

The Impact of Whole-body (18)^F-Fluorodeoxy-DGlucose Positron Emission Tomography - Computed Tomography (PET-CT) on the Staging and Outcome of Small Cell Lung Cancer Patients

胸腔醫學 (2014)

Shih‐Hong Li Kuo‐Chin Kao Kung‐Chu Ho Ping‐Chih Hsu Ning‐Hung Chen

Background: Determining the appropriate therapy for small cell lung cancer (SCLC) is highly dependent on accurate staging, which may have an impact on disease outcome. We evaluated whether the introduction of whole-body positron emission tomography with the glucose analog (18)^F-fluoro-2-deoxy-D-glucose (FDG-PET) improved the accuracy of staging, adequacy of therapy and clinical outcome of SCLC patients. Methods: The study design included prospective recording and retrospective analysis. From September 2007 to July 2012, a total 117 of newly diagnosed SCLC patients (mean age: 62 years, male/female: 107/10, Eastern Cooperative Oncology Group performance status (ECOG): 0-2, were enrolled for analysis. Sixty-nine patients received conventional computed tomography (CT) for staging, and 48 patients underwent both FDG-PET and conventional image studies for staging. All patients received protocol-oriented therapy on an intention-to-treat basis Chang Gung Memorial Hospital. Results: The clinical stage was changed in 14 of the 48 (29%) patients after FDG-PET (10 from limited-stage disease (LD) to extensive-stage disease (ED), 4 from ED to LD), and 34 remained at the same stage. The patients with LD as determined by FDG-PET had a longer median survival than those with LD by conventional staging (15.9 ± 14.2 months versus 9.5 ± 6.0 months; HR: 2.672; log-rank test p=0.0247). The median survival of patients with ED identified by FDG-PET staging was 9.3 ± 4.6 months, compared to 10.1 ± 8.2 months by CT scan (HR: 0.968; log-rank test p=0.9080). Conclusions: For limited-stage SCLC patients, the application of FDG-PET had a positive impact on staging, management and outcome; however, there was less impact on extensive-stage SCLC.

Log-rank test

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