The mechanism for memory T helper (Th) cell differentiation in malignant pleural effusion (MPE) of non-small cell lung cancer (NSCLC) is poorly understood. MicroRNAs (miRNAs), as small non-coding RNA that regulate gene expression, play a crucial role in the regulation of memory Th cell differentiation. However, whether miRNAs can inhibit the differentiation of memory Th cells in MPE of NSCLC has not been reported. This study aimed to explore miR-16-5p specifically inhibits interferon-gamma (IFN-γ)-regulated memory Th cell differentiation in MPE of NSCLC.

10.21037/tlcr-24-505

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ERS International Congress 2023: highlights from the Thoracic Surgery and Lung Transplantation Assembly

ERJ Open Research (2023)

Andrea Zajacová Marco Umberto Scaramozzino Alice Bellini Pallavi Purwar Sara Ricciardi

Five sessions presented at the European Respiratory Society Congress 2023 were selected by Assembly 8, consisting of thoracic surgeons and lung transplant professionals. Highlights covering management of adult spontaneous pneumothorax, malignant pleural effusion, infectious and immune-mediated complications after lung transplantation, as well as the pro and con debate on age limit in lung transplantation and results of the ScanCLAD study were summarised by early career members, supervised by the assembly faculty.

Cardiothoracic surgery

10.1183/23120541.00854-2023

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Robotic thymectomy in thymic tumours: a multicentre, nation-wide study

European Journal of Cardio-Thoracic Surgery (2024)

Giovanni Maria Comacchio Marco Schiavon Carmelina Cristina Zirafa Angela De Palma Roberto Scaramuzzi

Abstract OBJECTIVES Robotic thymectomy has been suggested and considered technically feasible for thymic tumours. However, because of small-sample series and the lack of data on long-term results, controversies still exist on surgical and oncological results with this approach. We performed a large national multicentre study sought to evaluate the early and long-term outcomes after robot-assisted thoracoscopic thymectomy in thymic epithelial tumours. METHODS All patients with thymic epithelial tumours operated through a robotic thoracoscopic approach between 2002 and 2022 from 15 Italian centres were enrolled. Demographic characteristics, clinical, intraoperative, postoperative, pathological and follow-up data were retrospectively collected and reviewed. RESULTS There were 669 patients (307 men and 362 women), 312 (46.6%) of whom had associated myasthenia gravis. Complete thymectomy was performed in 657 (98%) cases and in 57 (8.5%) patients resection of other structures was necessary, with a R0 resection in all but 9 patients (98.6%). Twenty-three patients (3.4%) needed open conversion, but no perioperative mortality occurred. Fifty-one patients (7.7%) had postoperative complications. The median diameter of tumour resected was 4 cm (interquartile range 3–5.5 cm), and Masaoka stage was stage I in 39.8% of patients, stage II in 56.1%, stage III in 3.5% and stage IV in 0.6%. Thymoma was observed in 90.2% of patients while thymic carcinoma occurred in 2.8% of cases. At the end of the follow-up, only 2 patients died for tumour-related causes. Five- and ten-year recurrence rates were 7.4% and 8.3%, respectively. CONCLUSIONS Through the largest collection of robotic thymectomy for thymic epithelial tumours we demonstrated that robot-enhanced thoracoscopic thymectomy is a technically sound and safe procedure with a low complication rate and optimal oncological outcomes.

Thymectomy

10.1093/ejcts/ezae178

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Tissue rearrangement, sclerotic lymph node

ASVIDE (2020)

Sara Ricciardi Federico Davini Gaetano Romano Carmelina Cristina Zirafa Franca Melfi

10.21037/asvide.2020.281

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[The use of guacetisal in chronic obstructive bronchopneumopathy. Controlled clinical study].

PubMed (1981)

Raffaella Cerqua C Trovello Gabriele Infante Sara Ricciardi

A single-blind, between-patients trial was run to compare the fluidifying, expectorant, antitussive, antipyretic and anti-inflammatory activity, and the local and systemic tolerance of guacetisal, an active principle obtained by the esterification of acetylsalicylic acid and guaiacol, and oxolamine phosphate, in which the suspension formulation for adults was administered to 30 presenile and senile patients of both sexes with chronic obstructive bronchopathy. A higher activity on the part of guacetisal was noted. The results obtained are illustrated and discussed.

Expectorant

Guaiacol

Antipyretic

Source

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Surgery for malignant pleural mesothelioma: an international guidelines review

Journal of Thoracic Disease (2018)

Sara Ricciardi Giuseppe Cardillo Carmelina Cristina Zirafa Francesco Carleo Francesco Facciolo

Abstract: Currently there is no universally accepted surgical therapy for malignant pleural mesothelioma (MPM). The goal of surgery in this dismal disease is a macroscopic complete resection (MCR) and there are two types of intervention with a curative intent. At one side, there is the extrapleural pneumonectomy (EPP) which consists in an en-bloc resection of the lung, pleura, pericardium and diaphragm and at the other side, there is pleurectomy/decortication (P/D) a lung-sparing surgery. Initially, EPP was considered the only surgical option with a curative aim, but during the decades P/D have acquired a role of increasing importance in MPM therapy. Several randomized prospective trials are required to establish the best strategy in the treatment of pleural mesothelioma. Although which is the best surgical option remains unclear, the International Mesothelioma Interest Group (IMIG), recently have stated that the type of surgery depends on clinical factors and on individual surgical judgment and expertise. Moreover, according to the current evidence, the surgery should be performed in high-volume centres within multimodality protocols. The aim of this study is to examine the currently available international guidelines in the surgical diagnosis and treatment of MPM.

Extrapleural Pneumonectomy

Pleurectomy

Decortication

10.21037/jtd.2017.10.16

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Citations (39)

Is LP(A) a risk factor for peripheral vascular disease in men?

Thrombosis Research (1992)

Alberto Artom David J. Mela G Cortassa Alessandra Berardini U Bonelli

10.1016/0049-3848(92)90659-x

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18F-FDG PET/CT diagnostic performance in solitary and multiple pulmonary nodules detected in patients with previous cancer history: reports of 182 nodules

European Journal of Nuclear Medicine and Molecular Imaging (2018)

Silvia Taralli Valentina Scolozzi Massimiliano Foti Sara Ricciardi Anna Rita Forcione

Nodule (geology)

Solitary pulmonary nodule

10.1007/s00259-018-4226-6

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Citations (24)

Chest wall resection for mesothelioma recurrence after surgery

Asian Cardiovascular and Thoracic Annals (2016)

Pietro Bertoglio Olivia Fanucchi Sara Ricciardi Antonio Chella Marco Lucchi

Malignant pleural mesothelioma is an aggressive and usually fatal disease, and its optimal management is still under debate. Surgery for recurrent malignant mesothelioma has been reported rarely in highly selected cases. We report a case of chest wall resection for local recurrence of epithelioid mesothelioma 3 years after cytoreductive surgery. Our patient experienced a 6-month disease-free survival after redo surgery, with complete resolution of his chest pain and discomfort.

Pleural disease

10.1177/0218492316674861

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Citations (4)